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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Wiedenheft, B."

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Search Summary

This query matches 19 Structures.

Refinements

Structure Determination Methodology

experimental (19)

Scientific Name of Source Organism

	Pseudomonas aeruginosa UCBPP-PA14 (6)
	Escherichia coli K-12 (4)
	Escherichia coli (3)
	Proteus penneri (2)
	Pseudomonas aeruginosa (2)
	Sulfolobus spindle-shaped virus 1 (2)
	Casadabanvirus D3112 (1)
	Escherichia coli B185 (1)
	Pseudomonas aeruginosa PA14 (1)
	Pseudomonas phage JBD30 (1)

More...

Taxonomy

	Bacteria (15)
	Archaea (2)
	Viruses incertae sedis (2)
	Duplodnaviria (1)
	other sequences (1)

Experimental Method

	X-RAY DIFFRACTION (12)
	ELECTRON MICROSCOPY (7)

Polymer Entity Type

	Protein (19)
	RNA (11)
	DNA (5)

Refinement Resolution (Å)

	1.5 - 2.0 (1)
	2.0 - 2.5 (6)
	2.5 - 3.0 (3)
	3.0 - 3.5 (7)
	3.5 - 4.0 (1)
	4.0 - 4.5 (1)

Release Date

	2000 - 2004 (2)
	2005 - 2009 (2)
	2010 - 2014 (5)
	2015 - 2019 (5)
	2020 - 2024 (5)

Enzyme Classification Name

	Hydrolases (13)
	Oxidoreductases (2)

Symmetry Type

	Asymmetric (15)
	Cyclic (2)
	Tetrahedral (2)
	Dihedral (1)

SCOP Classification

	All alpha proteins (2)
	Artifacts (3)
	Multi-domain proteins (alpha and beta) (2)
	Alpha and beta proteins (a+b) (1)

AllSelected

1 to 19 of 19 Structures

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1SKV \| pdb_00001skv	Download File View File

Crystal Structure of D-63 from Sulfolobus Spindle Virus 1

Kraft, P., Kummel, D., Oeckinghaus, A., Gauss, G.H., Wiedenheft, B., Young, M., Lawrence, C.M.

(2004) J Virol 78: 7438-7442

Released	2004-07-13
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Sulfolobus spindle-shaped virus 1
Macromolecule	Hypothetical 7.5 kDa protein (protein)

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1TBX \| pdb_00001tbx	Download File View File

Crystal structure of SSV1 F-93

Kraft, P., Oeckinghaus, A., Kummel, D., Gauss, G.H., Wiedenheft, B., Young, M., Lawrence, C.M.

(2004) J Virol 78: 11544-11550

Released	2004-07-13
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Sulfolobus spindle-shaped virus 1
Macromolecule	Hypothetical 11.0 kDa protein (protein)

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2CLB \| pdb_00002clb	Download File View File

The structure of the DPS-like protein from Sulfolobus solfataricus reveals a bacterioferritin-like di-metal binding site within a Dps- like dodecameric assembly

Gauss, G.H., Benas, P., Wiedenheft, B., Young, M., Douglas, T., Lawrence, C.M.

(2006) Biochemistry 45: 10815

Released	2006-07-17
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Saccharolobus solfataricus P2
Macromolecule	DPS-LIKE PROTEIN (protein)
Unique Ligands	FE, ZN

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2XLI \| pdb_00002xli	Download File View File

Crystal structure of the Csy4-crRNA complex, monoclinic form

Haurwitz, R.E., Jinek, M., Wiedenheft, B., Zhou, K., Doudna, J.A.

(2010) Science 329: 1355

Released	2010-09-22
Method	X-RAY DIFFRACTION 2.33 Å
Organisms	Pseudomonas aeruginosa UCBPP-PA14
Macromolecule	CSY4 ENDORIBONUCLEASE (protein) 5'-R(CPUPGPCPCPGPUPAPUPAPGPGPCPADGC)-3' (nucleic acid)

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2XLJ \| pdb_00002xlj	Download File View File

Crystal structure of the Csy4-crRNA complex, hexagonal form

Haurwitz, R.E., Jinek, M., Wiedenheft, B., Zhou, K., Doudna, J.A.

(2010) Science 329: 1355

Released	2010-09-22
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Pseudomonas aeruginosa UCBPP-PA14
Macromolecule	CSY4 ENDORIBONUCLEASE (protein) 5'-R(CPUPGPCPCPGPUPAPUPAPGPGPCPADGC)-3' (nucleic acid)

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2XLK \| pdb_00002xlk	Download File View File

Crystal structure of the Csy4-crRNA complex, orthorhombic form

Haurwitz, R.E., Jinek, M., Wiedenheft, B., Zhou, K., Doudna, J.A.

(2010) Science 329: 1355

Released	2010-09-22
Method	X-RAY DIFFRACTION 1.805 Å
Organisms	Pseudomonas aeruginosa UCBPP-PA14
Macromolecule	CSY4 ENDORIBONUCLEASE (protein) 5'-R(CPUPGPCPCPGPUPAPUPAPGPGPCPADGC)-3' (nucleic acid)

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3GOD \| pdb_00003god	Download File View File

Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated antiviral defense

Wiedenheft, B.

(2009) Structure 17: 904-912

Released	2009-06-30
Method	X-RAY DIFFRACTION 2.17 Å
Organisms	Pseudomonas aeruginosa UCBPP-PA14
Macromolecule	Cas1 (protein)
Unique Ligands	CA, MN, NA

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4AN8 \| pdb_00004an8	Download File View File

Structure of Thermus thermophilus CasA (Cse1)

Sashital, D.G., Wiedenheft, B., Doudna, J.A.

(2012) Mol Cell 46: 606

Released	2012-05-02
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Thermus thermophilus HB8
Macromolecule	CSE1 (protein)
Unique Ligands	ACT

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4TVX \| pdb_00004tvx	Download File View File

Crystal structure of the E. coli CRISPR RNA-guided surveillance complex, Cascade

Jackson, R.N., Golden, S.M., Carter, J., Wiedenheft, B.

(2014) Science 345: 1473-1479

Released	2014-08-13
Method	X-RAY DIFFRACTION 3.24 Å
Organisms	Escherichia coli Escherichia coli K-12
Macromolecule	Unique protein chains: 5 Unique nucleic acid chains: 1
Unique Ligands	ZN

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5CD4 \| pdb_00005cd4	Download File View File

The Type IE CRISPR Cascade complex from E. coli, with two assemblies in the asymmetric unit arranged back-to-back

Jackson, R.N., Golden, S.M., Carter, J., Wiedenheft, B.

(2015) Nucleic Acids Res 43: 8381-8391

Released	2015-08-26
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Escherichia coli K-12
Macromolecule	Unique protein chains: 5 Unique nucleic acid chains: 1
Unique Ligands	ZN

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5H9E \| pdb_00005h9e	Download File View File

Crystal structure of E. coli Cascade bound to a PAM-containing dsDNA target (32-nt spacer) at 3.20 angstrom resolution.

Hayes, R.P., Xiao, Y., Ding, F., van Erp, P.B.G., Rajashankar, K., Bailey, S., Wiedenheft, B., Ke, A.

(2016) Nature 530: 499-503

Released	2016-02-17
Method	X-RAY DIFFRACTION 3.21 Å
Organisms	Escherichia coli Escherichia coli K-12
Macromolecule	Unique protein chains: 5 Unique nucleic acid chains: 3
Unique Ligands	ZN

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5H9F \| pdb_00005h9f	Download File View File

Crystal structure of E. coli Cascade bound to a PAM-containing dsDNA target at 2.45 angstrom resolution.

Hayes, R.P., Xiao, Y., Ding, F., van Erp, P.B.G., Rajashankar, K., Bailey, S., Wiedenheft, B., Ke, A.

(2016) Nature 530: 499-503

Released	2016-02-17
Method	X-RAY DIFFRACTION 2.45 Å
Organisms	Escherichia coli Escherichia coli K-12
Macromolecule	Unique protein chains: 5 Unique nucleic acid chains: 3
Unique Ligands	ZN

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5UZ9 \| pdb_00005uz9	Download File View File

Cryo EM structure of anti-CRISPRs, AcrF1 and AcrF2, bound to type I-F crRNA-guided CRISPR surveillance complex

Chowdhury, S., Carter, J., Rollins, M.F., Jackson, R.N., Hoffmann, C., Nosaka, L., Bondy-Denomy, J., Maxwell, K.L., Davidson, A.R., Fischer, E.R., Lander, G.C., Wiedenheft, B.

(2017) Cell 169: 47-57.e11

Released	2017-04-26
Method	ELECTRON MICROSCOPY 3.4 Å
Organisms	Casadabanvirus D3112 Pseudomonas aeruginosa UCBPP-PA14 Pseudomonas phage JBD30
Macromolecule	Unique protein chains: 6 Unique nucleic acid chains: 1

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6NE0 \| pdb_00006ne0	Download File View File

Structure of double-stranded target DNA engaged Csy complex from Pseudomonas aeruginosa (PA-14)

Chowdhury, S., Rollins, M.F., Carter, J., Golden, S.M., Miettinen, H.M., Santiago-Frangos, A., Faith, D., Lawrence, M.C., Wiedenheft, B., Lander, G.C.

(2019) Mol Cell 74: 132-142.e5

Released	2018-12-26
Method	ELECTRON MICROSCOPY 3.4 Å
Organisms	Pseudomonas aeruginosa UCBPP-PA14
Macromolecule	Unique protein chains: 4 Unique nucleic acid chains: 3

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6W1X \| pdb_00006w1x	Download File View File

Cryo-EM structure of anti-CRISPR AcrIF9, bound to the type I-F crRNA-guided CRISPR surveillance complex

Hirschi, M., Santiago-Frangos, A., Wilkinson, R., Golden, S.M., Wiedenheft, B., Lander, G.

(2020) Nat Commun 11: 2730-2730

Released	2020-05-13
Method	ELECTRON MICROSCOPY 3.9 Å
Organisms	Proteus penneri Pseudomonas aeruginosa
Macromolecule	Unique protein chains: 5 Unique nucleic acid chains: 1

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6WHI \| pdb_00006whi	Download File View File

Cryo-electron microscopy structure of the type I-F CRISPR RNA-guided surveillance complex bound to the anti-CRISPR AcrIF9

Hirschi, M., Santiago-Frangos, A., Wilkinson, R., Golden, S.M., Wiedenheft, B., Lander, G.

(2020) Nat Commun 11: 2730-2730

Released	2020-05-13
Method	ELECTRON MICROSCOPY 4.2 Å
Organisms	Proteus penneri Pseudomonas aeruginosa
Macromolecule	Unique protein chains: 5 Unique nucleic acid chains: 3

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7STW \| pdb_00007stw	Download File View File

Structure of DPSL (DNA Protection in Starved Cells - Like) from Pyrococcus furiosus

Gauvin, C.C., Waghwani, H.K., Douglas, T., Lawrence, C.M.

To be published

Released	2021-12-01
Method	ELECTRON MICROSCOPY 2.37 Å
Organisms	Pyrococcus furiosus
Macromolecule	DNA protection during starvation protein (protein)
Unique Ligands	FE, ZN

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8FLJ \| pdb_00008flj	Download File View File

Cas1-Cas2/3 integrase and IHF bound to CRISPR leader, repeat and foreign DNA

Santiago-Frangos, A., Henriques, W.S., Wiegand, T., Gauvin, C., Buyukyoruk, M., Neselu, K., Eng, E.T., Lander, G.C., Wiedenheft, B.

(2023) Nat Struct Mol Biol 30: 1675-1685

Released	2023-09-06
Method	ELECTRON MICROSCOPY 3.48 Å
Organisms	Pseudomonas aeruginosa PA14 synthetic construct
Macromolecule	Unique protein chains: 4 Unique nucleic acid chains: 4

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8UX9 \| pdb_00008ux9	Download File View File

Asymmetric unit of the PARIS Immune Complex at 3.2 Angstrom Resolution

Burman, N.B., Henriques, W., Wilkinson, R., Graham, A., Wiedenheft, B.

(2024) Nature 634: 424-431

Released	2024-09-18
Method	ELECTRON MICROSCOPY 3.2 Å
Organisms	Escherichia coli B185
Macromolecule	AriA (protein) AriB (protein)
Unique Ligands	AGS

1 to 19 of 19 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

1SKV | pdb_00001skv

Crystal Structure of D-63 from Sulfolobus Spindle Virus 1

1TBX | pdb_00001tbx

Crystal structure of SSV1 F-93

2CLB | pdb_00002clb

The structure of the DPS-like protein from Sulfolobus solfataricus reveals a bacterioferritin-like di-metal binding site within a Dps- like dodecameric assembly

2XLI | pdb_00002xli

Crystal structure of the Csy4-crRNA complex, monoclinic form

2XLJ | pdb_00002xlj

Crystal structure of the Csy4-crRNA complex, hexagonal form

2XLK | pdb_00002xlk

Crystal structure of the Csy4-crRNA complex, orthorhombic form

3GOD | pdb_00003god

Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated antiviral defense

4AN8 | pdb_00004an8

Structure of Thermus thermophilus CasA (Cse1)

4TVX | pdb_00004tvx

Crystal structure of the E. coli CRISPR RNA-guided surveillance complex, Cascade

5CD4 | pdb_00005cd4

The Type IE CRISPR Cascade complex from E. coli, with two assemblies in the asymmetric unit arranged back-to-back

5H9E | pdb_00005h9e

Crystal structure of E. coli Cascade bound to a PAM-containing dsDNA target (32-nt spacer) at 3.20 angstrom resolution.

5H9F | pdb_00005h9f

Crystal structure of E. coli Cascade bound to a PAM-containing dsDNA target at 2.45 angstrom resolution.

5UZ9 | pdb_00005uz9

Cryo EM structure of anti-CRISPRs, AcrF1 and AcrF2, bound to type I-F crRNA-guided CRISPR surveillance complex

6NE0 | pdb_00006ne0

Structure of double-stranded target DNA engaged Csy complex from Pseudomonas aeruginosa (PA-14)

6W1X | pdb_00006w1x

Cryo-EM structure of anti-CRISPR AcrIF9, bound to the type I-F crRNA-guided CRISPR surveillance complex

6WHI | pdb_00006whi

Cryo-electron microscopy structure of the type I-F CRISPR RNA-guided surveillance complex bound to the anti-CRISPR AcrIF9

7STW | pdb_00007stw

Structure of DPSL (DNA Protection in Starved Cells - Like) from Pyrococcus furiosus

8FLJ | pdb_00008flj

Cas1-Cas2/3 integrase and IHF bound to CRISPR leader, repeat and foreign DNA

8UX9 | pdb_00008ux9

Asymmetric unit of the PARIS Immune Complex at 3.2 Angstrom Resolution

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1SKV | pdb_00001skv

1TBX | pdb_00001tbx

2CLB | pdb_00002clb

2XLI | pdb_00002xli

2XLJ | pdb_00002xlj

2XLK | pdb_00002xlk

3GOD | pdb_00003god

4AN8 | pdb_00004an8

4TVX | pdb_00004tvx

5CD4 | pdb_00005cd4

5H9E | pdb_00005h9e

5H9F | pdb_00005h9f

5UZ9 | pdb_00005uz9

6NE0 | pdb_00006ne0

6W1X | pdb_00006w1x

6WHI | pdb_00006whi

7STW | pdb_00007stw

8FLJ | pdb_00008flj

8UX9 | pdb_00008ux9