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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "csy3"

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Search Summary

This query matches 15 Structures.

Refinements

Structure Determination Methodology

experimental (15)

Scientific Name of Source Organism

	Homo sapiens (15)
	Mus musculus (3)
	Drosophila melanogaster (1)

Taxonomy

Eukaryota (15)

Experimental Method

	ELECTRON MICROSCOPY (11)
	X-RAY DIFFRACTION (3)
	SOLUTION NMR (1)

Polymer Entity Type

Protein (15)

Refinement Resolution (Å)

	2.5 - 3.0 (1)
	3.0 - 3.5 (6)
	3.5 - 4.0 (3)
	4.0 - 4.5 (3)
	> 4.5 (1)

Release Date

	2015 - 2019 (5)
	2020 - 2024 (10)

Enzyme Classification Name

Transferases (12)

Symmetry Type

	Asymmetric (10)
	Cyclic (5)
	Dihedral (1)

SCOP Classification

	Artifacts (1)
	Small proteins (1)

AllSelected

1 to 15 of 15 Structures

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4XSS \| pdb_00004xss	Download File View File

Insulin-like growth factor I in complex with site 1 of a hybrid insulin receptor / Type 1 insulin-like growth factor receptor

Lawrence, C., Kong, G.K.-W., Menting, J.G., Lawrence, M.C.

(2015) Structure 23: 1271-1282

Released	2015-06-10
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Insulin receptor (protein) Insulin-like growth factor I (protein) Insulin-like growth factor receptor alpha-CT peptide (protein)
Unique Ligands	NAG, SO4
Unique branched monosaccharides	BMA, FUC, NAG

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5U8Q \| pdb_00005u8q	Download File View File

Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor in complex with IGF-I

Lawrence, M., Xu, Y.

(2018) Nat Commun 9: 821-821

Released	2018-02-28
Method	X-RAY DIFFRACTION 3.27104018461 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Fv 24-60 heavy chain (protein) Fv 24-60 light chain (protein) Insulin-like growth factor 1 receptor (protein) Insulin-like growth factor I (protein)
Unique Ligands	MLT, NAG, SO4
Unique branched monosaccharides	MAN, NAG

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6FF3 \| pdb_00006ff3	Download File View File

Crystal structure of Drosophila neural ectodermal development factor Imp-L1 with Human IGF-I

Brzozowski, A.M., Kulahin, N., Kristensen, O., Schluckebier, G., Meyts, P.D., Viola, C.M.

(2018) Nat Commun 9: 3860-3860

Released	2018-09-26
Method	X-RAY DIFFRACTION 2.57 Å
Organisms	Drosophila melanogaster Homo sapiens
Macromolecule	Insulin-like growth factor I (protein) Neural/ectodermal development factor IMP-L2 (protein)

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6PYH \| pdb_00006pyh	Download File View File

Cryo-EM structure of full-length IGF1R-IGF1 complex. Only the extracellular region of the complex is resolved.

Li, J., Choi, E., Yu, H.T., Bai, X.C.

(2019) Nat Commun 10: 4567-4567

Released	2019-10-23
Method	ELECTRON MICROSCOPY 4.3 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Insulin-like growth factor 1 receptor (protein) Insulin-like growth factor I (protein)

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6RVA \| pdb_00006rva	Download File View File

STRUCTURE OF [ASP58]-IGF-I ANALOGUE

Jiracek, J., Zakova, L., Socha, O.

(2019) J Biological Chem 294: 17371-17382

Released	2019-10-02
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Insulin-like growth factor I (protein)

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7S0Q \| pdb_00007s0q	Download File View File

Head region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor

Xu, Y., Lawrence, M.C.

(2022) Structure 30: 1098-1108.e6

Released	2022-07-06
Method	ELECTRON MICROSCOPY 3.7 Å
Organisms	Homo sapiens
Macromolecule	Insulin receptor (protein) Insulin-like growth factor 1 receptor (protein) Insulin-like growth factor I (protein)
Unique Ligands	BMA, NAG
Unique branched monosaccharides	BMA, NAG

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7WRQ \| pdb_00007wrq	Download File View File

Structure of Human IGF1/IGFBP3/ALS Ternary Complex

Kim, H., Fu, Y., Kim, H.M.

(2022) Nat Commun 13: 4434

Released	2022-08-10
Method	ELECTRON MICROSCOPY 3.6 Å
Organisms	Homo sapiens
Macromolecule	Insulin-like growth factor-binding protein 3 (protein) Insulin-like growth factor-binding protein complex acid labile subunit (protein) Isoform 3 of Insulin-like growth factor I (protein)
Unique Ligands	NAG
Unique branched monosaccharides	BMA, NAG

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7YRR \| pdb_00007yrr	Download File View File

Cryo-EM structure of IGF1R with two IGF1 complex

Xi, Z., Cang, W.

To be published

Released	2023-08-16
Method	ELECTRON MICROSCOPY 4.3 Å
Organisms	Homo sapiens
Macromolecule	Insulin-like growth factor 1 receptor (protein) Isoform 3 of Insulin-like growth factor I (protein)

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8EYR \| pdb_00008eyr	Download File View File

Cryo-EM structure of two IGF1 bound full-length mouse IGF1R mutant (four glycine residues inserted in the alpha-CT; IGF1R-P674G4): symmetric conformation

Li, J., Wu, J.Y., Hall, C., Bai, X.C., Choi, E.

(2022) Elife 11:

Released	2022-11-09
Method	ELECTRON MICROSCOPY 4 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Insulin-like growth factor 1 receptor (protein) Insulin-like growth factor I (protein)

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8X06 \| pdb_00008x06	Download File View File

Cryo-EM structure of the IR/IGF-I complex, conformation 1

Xi, Z.

To be published

Released	2024-11-06
Method	ELECTRON MICROSCOPY 3.24 Å
Organisms	Homo sapiens
Macromolecule	Insulin-like growth factor I (protein) Isoform Short of Insulin receptor (protein)

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8X2M \| pdb_00008x2m	Download File View File

Cryo-EM structure of the IR/IGF-I complex, conformation 2

Xi, Z.

To be published

Released	2024-11-13
Method	ELECTRON MICROSCOPY 3.31 Å
Organisms	Homo sapiens
Macromolecule	Insulin-like growth factor I (protein) Isoform Short of Insulin receptor (protein)

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8XJS \| pdb_00008xjs	Download File View File

Cryo-EM structure of human insulin receptor bound to 3 IGF-I

Xi, Z.

To be published

Released	2024-12-25
Method	ELECTRON MICROSCOPY 3.24 Å
Organisms	Homo sapiens
Macromolecule	Insulin-like growth factor I (protein) Isoform Short of Insulin receptor (protein)

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8XK1 \| pdb_00008xk1	Download File View File

Cryo-EM structure of human insulin receptor bound to 4 IGF-I

Xi, Z.

To be published

Released	2024-12-25
Method	ELECTRON MICROSCOPY 3.31 Å
Organisms	Homo sapiens
Macromolecule	Insulin-like growth factor I (protein) Isoform Short of Insulin receptor (protein)

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8XKM \| pdb_00008xkm	Download File View File

Cryo-EM structure of human insulin receptor bound to 4 IGF-I, conformation 3

Xi, Z.

To be published

Released	2024-12-25
Method	ELECTRON MICROSCOPY 5 Å
Organisms	Homo sapiens
Macromolecule	Insulin-like growth factor I (protein) Isoform Short of Insulin receptor (protein)

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8XKR \| pdb_00008xkr	Download File View File

Cryo-EM structure of human insulin receptor bound to 4 IGF-I, conformation 2

Xi, Z.

To be published

Released	2024-12-25
Method	ELECTRON MICROSCOPY 3.53 Å
Organisms	Homo sapiens
Macromolecule	Insulin-like growth factor I (protein) Isoform Short of Insulin receptor (protein)

1 to 15 of 15 Structures

Page 1 of 1

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

4XSS | pdb_00004xss

Insulin-like growth factor I in complex with site 1 of a hybrid insulin receptor / Type 1 insulin-like growth factor receptor

5U8Q | pdb_00005u8q

Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor in complex with IGF-I

6FF3 | pdb_00006ff3

Crystal structure of Drosophila neural ectodermal development factor Imp-L1 with Human IGF-I

6PYH | pdb_00006pyh

Cryo-EM structure of full-length IGF1R-IGF1 complex. Only the extracellular region of the complex is resolved.

6RVA | pdb_00006rva

STRUCTURE OF [ASP58]-IGF-I ANALOGUE

7S0Q | pdb_00007s0q

Head region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor

7WRQ | pdb_00007wrq

Structure of Human IGF1/IGFBP3/ALS Ternary Complex

7YRR | pdb_00007yrr

Cryo-EM structure of IGF1R with two IGF1 complex

8EYR | pdb_00008eyr

Cryo-EM structure of two IGF1 bound full-length mouse IGF1R mutant (four glycine residues inserted in the alpha-CT; IGF1R-P674G4): symmetric conformation

8X06 | pdb_00008x06

Cryo-EM structure of the IR/IGF-I complex, conformation 1

8X2M | pdb_00008x2m

Cryo-EM structure of the IR/IGF-I complex, conformation 2

8XJS | pdb_00008xjs

Cryo-EM structure of human insulin receptor bound to 3 IGF-I

8XK1 | pdb_00008xk1

Cryo-EM structure of human insulin receptor bound to 4 IGF-I

8XKM | pdb_00008xkm

Cryo-EM structure of human insulin receptor bound to 4 IGF-I, conformation 3

8XKR | pdb_00008xkr

Cryo-EM structure of human insulin receptor bound to 4 IGF-I, conformation 2

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

4XSS | pdb_00004xss

5U8Q | pdb_00005u8q

6FF3 | pdb_00006ff3

6PYH | pdb_00006pyh

6RVA | pdb_00006rva

7S0Q | pdb_00007s0q

7WRQ | pdb_00007wrq

7YRR | pdb_00007yrr

8EYR | pdb_00008eyr

8X06 | pdb_00008x06

8X2M | pdb_00008x2m

8XJS | pdb_00008xjs

8XK1 | pdb_00008xk1

8XKM | pdb_00008xkm

8XKR | pdb_00008xkr