Download MendeleyStructural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex
Kim, H., Fu, Y., Hong, H.J., Lee, S.G., Lee, D.S., Kim, H.M.(2022) Nat Commun 13: 4434
7WRQ | pdb_00007wrq
Structure of Human IGF1/IGFBP3/ALS Ternary Complex
- PDB DOI: https://doi.org/10.2210/pdb7WRQ/pdb
- EM Map EMD-32735: EMDB EMDataResource
- Classification: SIGNALING PROTEIN
- Organism(s): Homo sapiens
- Expression System: Homo sapiens
- Mutation(s): No
- Deposited: 2022-01-27 Released: 2022-08-10
- Funding Organization(s): Other government
Experimental Data Snapshot
- Method: ELECTRON MICROSCOPY
- Resolution: 3.60 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
wwPDB Validation 3D Report Full Report
This is version 1.1 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Insulin-like growth factor-binding protein complex acid labile subunit | 578 | Homo sapiens | Mutation(s): 0 Gene Names: ALS |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P35858 (Homo sapiens) Explore P35858 Go to UniProtKB: P35858 | |||||
PHAROS: P35858 GTEx: ENSG00000099769 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P35858 | ||||
Glycosylation | |||||
| Glycosylation Sites: 5 | Go to GlyGen: P35858-1 | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Insulin-like growth factor-binding protein 3 | 264 | Homo sapiens | Mutation(s): 0 Gene Names: IGFBP3 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P17936 (Homo sapiens) Explore P17936 Go to UniProtKB: P17936 | |||||
PHAROS: P17936 GTEx: ENSG00000146674 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P17936 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 3 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Isoform 3 of Insulin-like growth factor I | 70 | Homo sapiens | Mutation(s): 0 Gene Names: IGF1 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P05019 (Homo sapiens) Explore P05019 Go to UniProtKB: P05019 | |||||
PHAROS: P05019 GTEx: ENSG00000017427 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P05019 | ||||
Sequence AnnotationsExpand | |||||
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Oligosaccharides
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| NAG Query on NAG | E [auth A], F [auth A], G [auth A], H [auth A] | 2-acetamido-2-deoxy-beta-D-glucopyranose C8 H15 N O6 OVRNDRQMDRJTHS-FMDGEEDCSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: ELECTRON MICROSCOPY
- Resolution: 3.60 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
Entry History & Funding Information
Deposition Data
| Funding Organization | Location | Grant Number |
|---|---|---|
| Other government | Institure of Basic Science, IBS-R030-C1 |
Revision History (Full details and data files)
- Version 1.0: 2022-08-10
Type: Initial release - Version 1.1: 2024-10-23
Changes: Data collection, Structure summary
