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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "blaT-5"

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Search Summary

This query matches 19 Structures.

Refinements

Structure Determination Methodology

experimental (19)

Scientific Name of Source Organism

	Homo sapiens (17)
	Rattus norvegicus (2)

Taxonomy

Eukaryota (19)

Experimental Method

X-RAY DIFFRACTION (19)

Polymer Entity Type

Protein (19)

Refinement Resolution (Å)

	1.0 - 1.5 (3)
	1.5 - 2.0 (10)
	2.0 - 2.5 (6)

Release Date

	2005 - 2009 (1)
	2010 - 2014 (7)
	2015 - 2019 (6)
	2020 - 2024 (5)

Enzyme Classification Name

	Isomerases (19)
	Transferases (19)

Symmetry Type

Cyclic (19)

SCOP Classification

	All alpha proteins (19)
	Alpha and beta proteins (a/b) (19)
	Artifacts (7)

AllSelected

1 to 19 of 19 Structures

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3EE2 \| pdb_00003ee2	Download File View File

Structure of human prostaglandin D-synthase (hGSTS1-1) in complex with nocodazole

Oakley, A.J.

(2010) Eur J Med Chem 45: 447-454

Released	2008-09-16
Method	X-RAY DIFFRACTION 1.91 Å
Organisms	Homo sapiens
Macromolecule	Glutathione-requiring prostaglandin D synthase (protein)
Unique Ligands	GSH, MG, NZO

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3KXO \| pdb_00003kxo	Download File View File

An orally active inhibitor bound at the active site of HPGDS

Kiefer, J.R., Day, J.E., Thorarensen, A.

To be published

Released	2010-09-01
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Glutathione-requiring prostaglandin D synthase (protein)
Unique Ligands	GSH, KXO, MG

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3VI5 \| pdb_00003vi5	Download File View File

Human hematopoietic prostaglandin D synthase inhibitor complex structures

Kado, Y., Inoue, T.

(2012) J Biochem 151: 447-455

Released	2012-04-18
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Hematopoietic prostaglandin D synthase (protein)
Unique Ligands	CA, GOL, GSH, M4M

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3VI7 \| pdb_00003vi7	Download File View File

Human hematopoietic prostaglandin D synthase inhibitor complex structures

Kado, Y., Inoue, T.

(2012) J Biochem 151: 447-455

Released	2012-04-18
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Hematopoietic prostaglandin D synthase (protein)
Unique Ligands	CA, CBD, GSH

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4EC0 \| pdb_00004ec0	Download File View File

Crystal structure of hH-PGDS with water displacing inhibitor

Day, J.E., Thorarensen, A., Trujillo, J.I.

(2012) Bioorg Med Chem Lett 22: 3795-3799

Released	2012-05-16
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens
Macromolecule	Hematopoietic prostaglandin D synthase (protein)
Unique Ligands	7PQ, GSH, MG

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4EDY \| pdb_00004edy	Download File View File

Crystal structure of hH-PGDS with water displacing inhibitor

Day, J.E., Thorarensen, A., Trujillo, J.I., Kiefer, J.R.

(2012) Bioorg Med Chem Lett 22: 3795-3799

Released	2012-10-03
Method	X-RAY DIFFRACTION 1.72 Å
Organisms	Homo sapiens
Macromolecule	Hematopoietic prostaglandin D synthase (protein)
Unique Ligands	9PQ, DMS, GSH, MG

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4EDZ \| pdb_00004edz	Download File View File

Crystal structure of hH-PGDS with water displacing inhibitor

Day, J.E., Thorarensen, A., Trujillo, J.I.

(2012) Bioorg Med Chem Lett 22: 3795-3799

Released	2012-05-16
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Hematopoietic prostaglandin D synthase (protein)
Unique Ligands	0O5, GSH, MG

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4EE0 \| pdb_00004ee0	Download File View File

Crystal structure of hH-PGDS with water displacing inhibitor

Day, J.E., Thorarensen, A., Trujillo, J.I.

(2012) Bioorg Med Chem Lett 22: 3795-3799

Released	2012-07-18
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	Hematopoietic prostaglandin D synthase (protein)
Unique Ligands	0O4, GSF, MG

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5Y9Z \| pdb_00005y9z	Download File View File

Crystal structure of rat hematopoietic prostaglandin D synthase

Kamo, M., Furubayashi, N., Inaka, K., Tanaka, H., Aritake, K., Urade, Y.

To be published

Released	2018-09-19
Method	X-RAY DIFFRACTION 1.09 Å
Organisms	Rattus norvegicus
Macromolecule	Hematopoietic prostaglandin D synthase (protein)
Unique Ligands	DIO, EDO, GOL, GSH, MG, PGE

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5YWE \| pdb_00005ywe	Download File View File

Crystal structure of hematopoietic prostaglandin D synthase apo form

Kamo, M., Furubayashi, N., Inaka, K., Aritake, K., Urade, Y.

To be published

Released	2018-12-05
Method	X-RAY DIFFRACTION 1.68 Å
Organisms	Homo sapiens
Macromolecule	Hematopoietic prostaglandin D synthase (protein)
Unique Ligands	GOL, GSH, MG

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5YWX \| pdb_00005ywx	Download File View File

Crystal structure of hematopoietic prostaglandin D synthase in complex with F092

Kamo, M., Furubayashi, N., Inaka, K., Aritake, K., Omura, A., Tanaka, A.

(2018) Bioorg Med Chem 26: 4726-4734

Released	2018-09-05
Method	X-RAY DIFFRACTION 1.74 Å
Organisms	Homo sapiens
Macromolecule	Hematopoietic prostaglandin D synthase (protein)
Unique Ligands	93C, GOL, GSH, MG

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5YX1 \| pdb_00005yx1	Download File View File

Crystal structure of hematopoietic prostaglandin D synthase in complex with U004

Kamo, M., Furubayashi, N., Inaka, K., Aritake, K., Urade, Y., Takaya, D., Tanaka, A.

To be published

Released	2018-12-05
Method	X-RAY DIFFRACTION 1.39 Å
Organisms	Homo sapiens
Macromolecule	Hematopoietic prostaglandin D synthase (protein)
Unique Ligands	GOL, GSH, MG, UX4

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6N4E \| pdb_00006n4e	Download File View File

hPGDS complexed with a quinoline-3-carboxamide

Shewchuk, L.M., Ward, P.

(2019) Bioorg Med Chem 27: 1456-1478

Released	2019-03-27
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Homo sapiens
Macromolecule	Hematopoietic prostaglandin D synthase (protein)
Unique Ligands	GSH, KCD

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6N69 \| pdb_00006n69	Download File View File

rat hPGDS complexed with a quinoline

Shewchuk, L.M., Cleasby, A.

(2019) Bioorg Med Chem 27: 1456-1478

Released	2019-03-27
Method	X-RAY DIFFRACTION 2 Å
Organisms	Rattus norvegicus
Macromolecule	Hematopoietic prostaglandin D synthase (protein)
Unique Ligands	GSH, KDV

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6W58 \| pdb_00006w58	Download File View File

hPGDS complexed with an aza-quinoline

Elkins, P.A., Ward, P.

(2020) Bioorg Med Chem 28: 115791-115791

Released	2020-11-04
Method	X-RAY DIFFRACTION 2.395 Å
Organisms	Homo sapiens
Macromolecule	Hematopoietic prostaglandin D synthase (protein)
Unique Ligands	GSH, SWS

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6W8H \| pdb_00006w8h	Download File View File

H-PGDS complexed with inhibitor 1Y

Shewchuk, L.M., Ward, P.

(2020) Bioorg Med Chem 28: 115791-115791

Released	2020-11-04
Method	X-RAY DIFFRACTION 1.97 Å
Organisms	Homo sapiens
Macromolecule	Hematopoietic prostaglandin D synthase (protein)
Unique Ligands	EDO, GSH, TJG

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6ZTC \| pdb_00006ztc	Download File View File

CRYSTAL STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE IN COMPLEX WITH FRAGMENT 1A AT 1.84A RESOLUTION.

Somers, D.O.

(2021) Bioorg Med Chem Lett 47: 128113-128113

Released	2021-07-28
Method	X-RAY DIFFRACTION 1.84 Å
Organisms	Homo sapiens
Macromolecule	Hematopoietic prostaglandin D synthase (protein)
Unique Ligands	GOL, GSH, MG, QPN

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7JR6 \| pdb_00007jr6	Download File View File

H-PDGS complexed with a 2-phenylimidazo[1,2-a]pyridine-6-carboxamide inhibitors

Nolte, R.T., Somers, D.O., Gampe, R.T.

(2021) Bioorg Med Chem Lett 47: 128113-128113

Released	2021-05-26
Method	X-RAY DIFFRACTION 1.88 Å
Organisms	Homo sapiens
Macromolecule	Hematopoietic prostaglandin D synthase (protein)
Unique Ligands	GSH, MG, NA, VH4

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7JR8 \| pdb_00007jr8	Download File View File

H-PDGS complexed with a 2-phenylimidazo[1,2-a]pyridine-6-carboxamide inhibitors

Nolte, R.T., Somers, D.O., Gampe, R.T.

(2021) Bioorg Med Chem Lett 47: 128113-128113

Released	2021-05-26
Method	X-RAY DIFFRACTION 1.13 Å
Organisms	Homo sapiens
Macromolecule	Hematopoietic prostaglandin D synthase (protein)
Unique Ligands	CL, EDO, GSH, MG, NA, VH7

1 to 19 of 19 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

3EE2 | pdb_00003ee2

Structure of human prostaglandin D-synthase (hGSTS1-1) in complex with nocodazole

3KXO | pdb_00003kxo

An orally active inhibitor bound at the active site of HPGDS

3VI5 | pdb_00003vi5

Human hematopoietic prostaglandin D synthase inhibitor complex structures

3VI7 | pdb_00003vi7

Human hematopoietic prostaglandin D synthase inhibitor complex structures

4EC0 | pdb_00004ec0

Crystal structure of hH-PGDS with water displacing inhibitor

4EDY | pdb_00004edy

Crystal structure of hH-PGDS with water displacing inhibitor

4EDZ | pdb_00004edz

Crystal structure of hH-PGDS with water displacing inhibitor

4EE0 | pdb_00004ee0

Crystal structure of hH-PGDS with water displacing inhibitor

5Y9Z | pdb_00005y9z

Crystal structure of rat hematopoietic prostaglandin D synthase

5YWE | pdb_00005ywe

Crystal structure of hematopoietic prostaglandin D synthase apo form

5YWX | pdb_00005ywx

Crystal structure of hematopoietic prostaglandin D synthase in complex with F092

5YX1 | pdb_00005yx1

Crystal structure of hematopoietic prostaglandin D synthase in complex with U004

6N4E | pdb_00006n4e

hPGDS complexed with a quinoline-3-carboxamide

6N69 | pdb_00006n69

rat hPGDS complexed with a quinoline

6W58 | pdb_00006w58

hPGDS complexed with an aza-quinoline

6W8H | pdb_00006w8h

H-PGDS complexed with inhibitor 1Y

6ZTC | pdb_00006ztc

CRYSTAL STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE IN COMPLEX WITH FRAGMENT 1A AT 1.84A RESOLUTION.

7JR6 | pdb_00007jr6

H-PDGS complexed with a 2-phenylimidazo[1,2-a]pyridine-6-carboxamide inhibitors

7JR8 | pdb_00007jr8

H-PDGS complexed with a 2-phenylimidazo[1,2-a]pyridine-6-carboxamide inhibitors

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

3EE2 | pdb_00003ee2

3KXO | pdb_00003kxo

3VI5 | pdb_00003vi5

3VI7 | pdb_00003vi7

4EC0 | pdb_00004ec0

4EDY | pdb_00004edy

4EDZ | pdb_00004edz

4EE0 | pdb_00004ee0

5Y9Z | pdb_00005y9z

5YWE | pdb_00005ywe

5YWX | pdb_00005ywx

5YX1 | pdb_00005yx1

6N4E | pdb_00006n4e

6N69 | pdb_00006n69

6W58 | pdb_00006w58

6W8H | pdb_00006w8h

6ZTC | pdb_00006ztc

7JR6 | pdb_00007jr6

7JR8 | pdb_00007jr8