NZO

nocodazole

Created:	2008-09-04
Last modified:	2020-06-05

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2 entries where NZO is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	32
Chiral Atom Count	0
Bond Count	34
Aromatic Bond Count	15

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Chemical Component Summary
Name	nocodazole
Synonyms	methyl [6-(thiophen-2-ylcarbonyl)-1H-benzimidazol-2-yl]carbamate
Systematic Name (OpenEye OEToolkits)	methyl N-(6-thiophen-2-ylcarbonyl-1H-benzimidazol-2-yl)carbamate
Formula	C₁₄ H₁₁ N₃ O₃ S
Molecular Weight	301.32
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(c2cc1c(nc(NC(=O)OC)n1)cc2)c3sccc3
SMILES	CACTVS	3.341	COC(=O)Nc1[nH]c2cc(ccc2n1)C(=O)c3sccc3
SMILES	OpenEye OEToolkits	1.5.0	COC(=O)Nc1[nH]c2cc(ccc2n1)C(=O)c3cccs3
Canonical SMILES	CACTVS	3.341	COC(=O)Nc1[nH]c2cc(ccc2n1)C(=O)c3sccc3
Canonical SMILES	OpenEye OEToolkits	1.5.0	COC(=O)Nc1[nH]c2cc(ccc2n1)C(=O)c3cccs3
InChI	InChI	1.03	InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
InChIKey	InChI	1.03	KYRVNWMVYQXFEU-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB08313
Name	Nocodazole
Groups	experimental
Description	Nocodazole is an antineoplastic agent which exerts its effect by depolymerizing microtubules.
Synonyms	Oncodazole Nocodazole Nocodazol Nocodazolum
Categories	Antimitotic Agents Antineoplastic Agents Benzimidazoles Heterocyclic Compounds, Fused-Ring Mitosis Modulators Tubulin Modulators
CAS number	31430-18-9

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Hematopoietic prostaglandin D synthase	MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGK...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682