5DIR

membrane protein at 2.8 Angstroms

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	Peptidase_A8	e5dirC1	A: alpha bundles	X: Lipoprotein signal peptidase (From Topology)	H: Lipoprotein signal peptidase (From Topology)	T: Lipoprotein signal peptidase	F: Peptidase_A8	ECOD (1.6)
D	Peptidase_A8	e5dirD1	A: alpha bundles	X: Lipoprotein signal peptidase (From Topology)	H: Lipoprotein signal peptidase (From Topology)	T: Lipoprotein signal peptidase	F: Peptidase_A8	ECOD (1.6)
A	Peptidase_A8	e5dirA1	A: alpha bundles	X: Lipoprotein signal peptidase (From Topology)	H: Lipoprotein signal peptidase (From Topology)	T: Lipoprotein signal peptidase	F: Peptidase_A8	ECOD (1.6)
B	Peptidase_A8	e5dirB1	A: alpha bundles	X: Lipoprotein signal peptidase (From Topology)	H: Lipoprotein signal peptidase (From Topology)	T: Lipoprotein signal peptidase	F: Peptidase_A8	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01252	Signal peptidase (SPase) II (Peptidase_A8)	Signal peptidase (SPase) II	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Lipoprotein signal peptidase	aspartic-type peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity aspartic-type endopeptidase activity catalytic activity endopeptidase activity	signal peptide processing primary metabolic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis protein processing metabolic process cellular process protein metabolic process macromolecule metabolic process	cell periphery cellular anatomical structure plasma membrane membrane
E, F, G, H	Globomycin	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR001872	Peptidase A8, signal peptidase II	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D	OPM	Transmembrane	Alpha-helical polytopic	Peptidase A8	Lipoprotein signal peptidase

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Intramembrane Proteases	Lipoprotein signal peptidase II

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
E, F, G, H	5BV
E, F, G, H	ALO	Parent Component: THR
E, F, G, H	IIL	Parent Component: ILE
E, F, G, H	MLE	Parent Component: LEU RESID: AA0337 PSI-MOD : N-methyl-L-leucine MOD:00342

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.