THR

THREONINE

Find entries where: THR

is present as a standalone ligand in 33 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 17 entries

is present in a polymer sequence 220,340 entries

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Chemical Component Summary
Name	THREONINE
Identifiers	(2S,3R)-2-amino-3-hydroxy-butanoic acid
Formula	C₄ H₉ N O₃
Molecular Weight	119.119
Type	L-PEPTIDE LINKING
Isomeric SMILES	C[C@H]([C@@H](C(=O)O)N)O
InChI	InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1
InChIKey	AYFVYJQAPQTCCC-GBXIJSLDSA-N

Chemical Details
Formal Charge	0
Atom Count	17
Chiral Atom Count	2
Bond Count	16
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00156
Name	Threonine
Groups	approved nutraceutical
Description	An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.
Synonyms	L-Threonine L-Threonin Thr L-α-amino-β-hydroxybutyric acid (2S,3R)-(-)-Threonine L-2-Amino-3-hydroxybutyric acid Treonina 2-Amino-3-hydroxybutyric acid L-alpha-amino-beta-hydroxybutyric acid L-(-)-Threonine Threoninum Threonine (2S)-threonine
Brand Names	4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Premasol - sulfite-free (Amino Acid) Aminosyn-PF 10% FreAmine III Travasol E Renamin (amino Acids) Injection 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose ProcalAmine 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Aminosyn Sulfite Free Travasol 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Olimel 3.3% E Aminosyn RF Injection Clinisol Primene 10%-liq IV 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn II with Electrolytes Smofkabiven Vamin N Smofkabiven Extra Nitrogen Electrolyte Free 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Periolimel 2.5% E 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Plenamine Aminosyn 5% RenAmin 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix Primene 10% Novamine Aminosyn II 7% M In 10% Dextrose(dual Chamber) Perikabiven Olimel 5.7% E 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Aminosyn RF Essepna 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Aminosyn 10% W Electrolytes Aminosyn Aminosyn II 5% Inj Olimel 4.4% Aminosyn II Aminosyn II in Dextrose HepatAmine Aminosyn II 7% With 10% Dextrose 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Travasol Amino Acid Inj 8.5% 8.5% Freamine III 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix Smofkabiven Peripheral Aminosyn 7% Travasol Amino Acid Inj 5.5% 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn II 8.5% Injection Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Olimel 4.4% E Olimel 5.7% Nephramine Liq IV 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Synthamin Aminosyn 8.5% Vamin 18 Electrolyte-free Smofkabiven Extra Nitrogen 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix Aminosyn II 8.5% With 50% Dextrose Nutrineal Pd4 Aminosyn II with Electrolytes in Dextrose with Calcium Aminosyn II In Dextrose Injection Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Primene Smofkabiven Electrolyte Free Aminosyn HF 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Travasol Inj Without Electrolytes 8.5% Kabiven 20% Prosol Hepatasol Travasol Inj Without Electrolytes 5.5% Aminosyn-PF Aminosyn II and Dextrose Cicatrin Powder Aminosyn 3.5% M ProSol NephrAmine Aminosyn II 7% Injection Clinimix FreAmine HBC Aminosyn 8.5% Injection With Electrolytes Aminosyn II 7% With 50% Dextrose Aminosyn II 10% With Electrolytes 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn-PF 7% Clinimix E TrophAmine Aminoderm Poudre Olimel 7.6% Olimel 7.6% E 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 4.25%travasol Amino Acid InJ.W.elecw.5%dex.
Indication	L-Threonine makes up collagen, elastin, and enamel protein. It aids proper fat metabolism in the liver, helps the digestive and intestinal tracts function more smoothly, and assists in metabolism and assimilation.
Categories	Amino Acids Amino Acids, Essential Amino Acids, Neutral Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements Threonine, antagonists & inhibitors
CAS number	72-19-5

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Threonine--tRNA ligase, cytoplasmic	MFEEKASSPSGKMGGEEKPIGAGEEKQKEGGKKKNKEGSGDGGRAELNPW...	unknown
Threonine--tRNA ligase, mitochondrial	MALYQRWRCLRLQGLQACRLHTAVVSTPPRWLAERLGLFEELWAAQVKRL...	unknown
Beta-lactamase Toho-1	MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGV...	unknown	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682