Substrate Promiscuity, Crystal Structure, and Application of a Plant UDP-Glycosyltransferase UGT74AN3
Huang, W., Zhang, X., Li, J., Lv, J., Wang, Y., He, Y., Song, J., Agren, H., Jiang, R., Deng, Z., Long, F.(2024) ACS Catal 14: 475-488
Experimental Data Snapshot
Starting Model: in silico
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Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Glycosyltransferase | 474 | Catharanthus roseus | Mutation(s): 0 EC: 2.4.1 | ![]() | |
UniProt | |||||
Find proteins for W8JMV4 (Catharanthus roseus) Explore W8JMV4 Go to UniProtKB: W8JMV4 | |||||
Entity Groups | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | W8JMV4 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 2 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
UDP Query on UDP | C [auth A] | URIDINE-5'-DIPHOSPHATE C9 H14 N2 O12 P2 XCCTYIAWTASOJW-XVFCMESISA-N | |||
6JI (Subject of Investigation/LOI) Query on 6JI | B [auth A] | 5-[(1R,2S,4R,6R,7R,10S,11S,14S,16R)-14-hydroxy-7,11-dimethyl-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-6-yl]pyran-2-one C24 H32 O4 ATLJNLYIJOCWJE-CWMZOUAVSA-N |
Length ( Å ) | Angle ( ˚ ) |
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a = 46.022 | α = 90 |
b = 53.005 | β = 90 |
c = 200.795 | γ = 90 |
Software Name | Purpose |
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PHENIX | refinement |
XDS | data reduction |
Aimless | data scaling |
PHENIX | phasing |
Funding Organization | Location | Grant Number |
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National Natural Science Foundation of China (NSFC) | China | -- |