Substrate Promiscuity, Crystal Structure, and Application of a Plant UDP-Glycosyltransferase UGT74AN3
Huang, W., Zhang, X., Li, J., Lv, J., Wang, Y., He, Y., Song, J., Agren, H., Jiang, R., Deng, Z., Long, F.(2024) ACS Catal 14: 475-488
Experimental Data Snapshot
Starting Model: experimental
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Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Glycosyltransferase | 464 | Catharanthus roseus | Mutation(s): 0 EC: 2.4.1 | ![]() | |
UniProt | |||||
Find proteins for W8JMV4 (Catharanthus roseus) Explore W8JMV4 Go to UniProtKB: W8JMV4 | |||||
Entity Groups | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | W8JMV4 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 3 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
UDP Query on UDP | C [auth A] | URIDINE-5'-DIPHOSPHATE C9 H14 N2 O12 P2 XCCTYIAWTASOJW-XVFCMESISA-N | |||
Q30 Query on Q30 | B [auth A] | 3-[(3S,5S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3,5,14-tris(oxidanyl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one C23 H34 O5 QJPCKAJTLHDNCS-STPRYWCXSA-N | |||
TRS (Subject of Investigation/LOI) Query on TRS | D [auth A] | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL C4 H12 N O3 LENZDBCJOHFCAS-UHFFFAOYSA-O |
Length ( Å ) | Angle ( ˚ ) |
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a = 45.608 | α = 90 |
b = 52.2 | β = 90 |
c = 200.701 | γ = 90 |
Software Name | Purpose |
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Blu-Ice | data collection |
PHENIX | refinement |
XDS | data reduction |
Aimless | data scaling |
Funding Organization | Location | Grant Number |
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National Natural Science Foundation of China (NSFC) | China | -- |