Targeting an essential step in the biosynthetic pathway of uridine diphosphate glucose in Aspergillus fumigatus
Yan, K., Stanley, M., Kowalski, B., Raimi, O.G., Ferenbach, A.T., Wei, P.Z., Yuan, H., Fang, W., van Aalten, D.M.F.To be published.
Experimental Data Snapshot
Starting Model: experimental
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Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Phosphoglucomutase | 560 | Aspergillus fumigatus | Mutation(s): 0 Gene Names: CDV57_06471 EC: 5.4.2.2 | ![]() | |
UniProt | |||||
Find proteins for Q4WY53 (Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293)) Explore Q4WY53 Go to UniProtKB: Q4WY53 | |||||
Entity Groups | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q4WY53 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 2 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
G16 (Subject of Investigation/LOI) Query on G16 | C [auth A], E [auth B] | 1,6-di-O-phosphono-alpha-D-glucopyranose C6 H13 O12 P2 RWHOZGRAXYWRNX-VFUOTHLCSA-M | |||
MG (Subject of Investigation/LOI) Query on MG | D [auth A], F [auth B] | MAGNESIUM ION Mg JLVVSXFLKOJNIY-UHFFFAOYSA-N |
Length ( Å ) | Angle ( ˚ ) |
---|---|
a = 98.57 | α = 90 |
b = 209.61 | β = 90 |
c = 61.2 | γ = 90 |
Software Name | Purpose |
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MOLREP | phasing |
REFMAC | refinement |
PDB_EXTRACT | data extraction |
autoPROC | data reduction |
autoPROC | data scaling |
Funding Organization | Location | Grant Number |
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Medical Research Council (MRC, United Kingdom) | United Kingdom | V001094 |