Structure of human hydroxyacid oxidase 1 bound with FMN and glycolate
MacKinnon, S., Bezerra, G.A., Krojer, T., Smee, C., Arrowsmith, C.H., Edwards, E., Bountra, C., Oppermann, U., Brennan, P.E., Yue, W.W.To be published.
Experimental Data Snapshot
Starting Model: experimental
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Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Hydroxyacid oxidase 1 | 368 | Homo sapiens | Mutation(s): 0 Gene Names: HAO1, GOX1, HAOX1 EC: 1.1.3.15 (PDB Primary Data), 1.2.3.5 (UniProt) | ![]() | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q9UJM8 (Homo sapiens) Explore Q9UJM8 Go to UniProtKB: Q9UJM8 | |||||
PHAROS: Q9UJM8 GTEx: ENSG00000101323 | |||||
Entity Groups | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q9UJM8 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 3 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
FMN Query on FMN | F [auth A] | FLAVIN MONONUCLEOTIDE C17 H21 N4 O9 P FVTCRASFADXXNN-SCRDCRAPSA-N | |||
C7C Query on C7C | G [auth A] | 5-[(4-chlorophenyl)sulfanyl]-1,2,3-thiadiazole-4-carboxylate C9 H4 Cl N2 O2 S2 NDYKFFAREALEPX-UHFFFAOYSA-M | |||
EDO Query on EDO | B [auth A], C [auth A], D [auth A], E [auth A] | 1,2-ETHANEDIOL C2 H6 O2 LYCAIKOWRPUZTN-UHFFFAOYSA-N |
Length ( Å ) | Angle ( ˚ ) |
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a = 97.348 | α = 90 |
b = 97.348 | β = 90 |
c = 80.363 | γ = 90 |
Software Name | Purpose |
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REFMAC | refinement |
SCALA | data scaling |
PDB_EXTRACT | data extraction |
SCALA | data scaling |
PHASER | phasing |
XDS | data reduction |
Funding Organization | Location | Grant Number |
---|---|---|
Wellcome Trust | United Kingdom | 106169/ZZ14/Z |