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235,183 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Keywords HAS EXACT PHRASE "Hydrolase/Peptide"

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Search Summary

This query matches 75 Structures.

Refinements

Structure Determination Methodology

experimental (75)

Scientific Name of Source Organism

	Homo sapiens (34)
	Human immunodeficiency virus 1 (11)
	synthetic construct (9)
	Bos taurus (4)
	Drosophila melanogaster (4)
	Clostridium perfringens (3)
	Escherichia coli (3)
	Arabidopsis thaliana (2)
	Bacillus subtilis subsp. subtilis str. 168 (2)
	Escherichia coli BL21 (2)

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Taxonomy

	Eukaryota (45)
	Riboviria (21)
	Bacteria (14)
	other sequences (9)
	Eukaryota (eukaryotes) (3)
	Archaea (1)
	Duplodnaviria (1)

Experimental Method

	X-RAY DIFFRACTION (74)
	ELECTRON MICROSCOPY (1)

Polymer Entity Type

Protein (75)

Refinement Resolution (Å)

	1.0 - 1.5 (3)
	1.5 - 2.0 (26)
	2.0 - 2.5 (19)
	2.5 - 3.0 (20)
	3.0 - 3.5 (5)
	3.5 - 4.0 (2)

Release Date

	1990 - 1994 (4)
	1995 - 1999 (10)
	2000 - 2004 (3)
	2005 - 2009 (2)
	2010 - 2014 (37)
	2015 - 2019 (18)
	2020 - 2024 (1)

Enzyme Classification Name

	Hydrolases (55)
	Transferases (13)
	Ligases (2)

Membrane Protein Annotation

	MemProtMD (1)
	PDBTM (1)
	mpstruc (1)

Symmetry Type

	Asymmetric (65)
	Cyclic (11)
	Dihedral (2)

SCOP Classification

	All beta proteins (15)
	Alpha and beta proteins (a+b) (2)
	Alpha and beta proteins (a/b) (5)
	All alpha proteins (2)
	Small proteins (2)
	Artifacts (1)

AllSelected

1 to 25 of 75 Structures

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1EJY \| pdb_00001ejy	Download File View File

MOUSE IMPORTIN ALPHA-NUCLEOPLASMIN NLS PEPTIDE COMPLEX

Fontes, M.R., Teh, T., Kobe, B.

(2000) J Mol Biology 297: 1183-1194

Released	2000-04-24
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Mus musculus Xenopus laevis
Macromolecule	IMPORTIN ALPHA (protein) NUCLEOPLASMIN NLS PEPTIDE (protein)

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1GCT \| pdb_00001gct	Download File View File

IS GAMMA-CHYMOTRYPSIN A TETRAPEPTIDE ACYL-ENZYME ADDUCT OF GAMMA-CHYMOTRYPSIN?

Dixon, M.M., Matthews, B.W.

(1989) Biochemistry 28: 7033-7038

Released	1991-10-15
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Bos taurus
Macromolecule	GAMMA-CHYMOTRYPSIN A (protein) TETRAPEPTIDE ADDUCT (protein)
Unique Ligands	SO4

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1JD5 \| pdb_00001jd5	Download File View File

Crystal Structure of DIAP1-BIR2/GRIM

Wu, J.W., Cocina, A.E., Chai, J., Hay, B.A., Shi, Y.

(2001) Mol Cell 8: 95-104

Released	2001-12-05
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Drosophila melanogaster
Macromolecule	APOPTOSIS 1 INHIBITOR (protein) cell death protein GRIM (protein)
Unique Ligands	ZN

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1JD6 \| pdb_00001jd6	Download File View File

Crystal Structure of DIAP1-BIR2/Hid Complex

Wu, J.W., Cocina, A.E., Chai, J., Hay, B.A., Shi, Y.

(2001) Mol Cell 8: 95-104

Released	2001-12-05
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Drosophila melanogaster
Macromolecule	APOPTOSIS 1 INHIBITOR (protein) head involution defective protein (protein)
Unique Ligands	ZN

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1YTG \| pdb_00001ytg	Download File View File

SIV PROTEASE CRYSTALLIZED WITH PEPTIDE PRODUCT

Rose, R.B., Craik, C.S., Douglas, N.L., Stroud, R.M.

(1996) Biochemistry 35: 12933-12944

Released	1997-03-12
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Human immunodeficiency virus 1
Macromolecule	HIV PROTEASE (protein) PEPTIDE PRODUCT (protein)

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1YTH \| pdb_00001yth	Download File View File

SIV PROTEASE CRYSTALLIZED WITH PEPTIDE PRODUCT

Rose, R.B., Craik, C.S., Douglas, N.L., Stroud, R.M.

(1996) Biochemistry 35: 12933-12944

Released	1997-03-12
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Human immunodeficiency virus 1
Macromolecule	HIV PROTEASE (protein) PEPTIDE PRODUCT (protein)

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1YTJ \| pdb_00001ytj	Download File View File

SIV PROTEASE CRYSTALLIZED WITH PEPTIDE PRODUCT

Rose, R.B., Craik, C.S., Douglas, N.L., Stroud, R.M.

(1996) Biochemistry 35: 12933-12944

Released	1997-03-12
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Simian immunodeficiency virus
Macromolecule	PEPTIDE PRODUCT (protein) SIV PROTEASE (protein)

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2GCT \| pdb_00002gct	Download File View File

STRUCTURE OF GAMMA-CHYMOTRYPSIN IN THE RANGE PH 2.0 TO PH 10.5 SUGGESTS THAT GAMMA-CHYMOTRYPSIN IS A COVALENT ACYL-ENZYME ADDUCT AT LOW PH

Dixon, M.M., Matthews, B.W.

(1991) Int J Biol Macromol 13: 89-96

Released	1991-10-15
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Bos taurus
Macromolecule	GAMMA-CHYMOTRYPSIN A (protein) TETRAPEPTIDE ADDUCT (protein)
Unique Ligands	SO4

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2WV4 \| pdb_00002wv4	Download File View File

Crystal structure of foot-and-mouth disease virus 3C protease in complex with a decameric peptide corresponding to the VP1-2A cleavage junction

Zunszain, P.A., Knox, S.R., Sweeney, T.R., Yang, J., Roque-Rosell, N., Belsham, G.J., Leatherbarrow, R.J., Curry, S.

(2010) J Mol Biology 395: 375

Released	2009-10-27
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Foot-and-mouth disease virus (strain A10-61)
Macromolecule	FOOT AND MOUTH DISEASE VIRUS (SEROTYPE A) VARIANT VP1 CAPSID PROTEIN (protein) PICORNAIN 3C (protein)

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2WV5 \| pdb_00002wv5	Download File View File

Crystal structure of foot-and-mouth disease virus 3C protease in complex with a decameric peptide corresponding to the VP1-2A cleavage junction with a GLN to Glu substitution at P1

Zunszain, P.A., Knox, S.R., Sweeney, T.R., Yang, J., Roque-Rosell, N., Belsham, G.J., Leatherbarrow, R.J., Curry, S.

(2010) J Mol Biology 395: 375

Released	2009-10-27
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Foot-and-mouth disease virus (strain A10-61)
Macromolecule	FOOT AND MOUTH DISEASE VIRUS (SEROTYPE A) VARIANT VP1 CAPSID PROTEIN (protein) PICORNAIN 3C (protein)

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2XNS \| pdb_00002xns	Download File View File

Crystal Structure Of Human G alpha i1 Bound To A Designed Helical Peptide Derived From The Goloco Motif Of RGS14

Bosch, D., Sammond, D.W., Butterfoss, G.L., Machius, M., Siderovski, D.P., Kuhlman, B.

(2011) J Am Chem Soc 133: 4190

Released	2011-06-08
Method	X-RAY DIFFRACTION 3.41 Å
Organisms	Homo sapiens
Macromolecule	GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-1 (protein) REGULATOR OF G-PROTEIN SIGNALING 14 (protein)
Unique Ligands	GDP, SO4, SRT

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2YDQ \| pdb_00002ydq	Download File View File

CpOGA D298N in complex with hOGA-derived O-GlcNAc peptide

Schimpl, M., Borodkin, V.S., Gray, L.J., van Aalten, D.M.F.

(2012) Chem Biol 19: 173

Released	2012-03-14
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Clostridium perfringens Homo sapiens
Macromolecule	BIFUNCTIONAL PROTEIN NCOAT (protein) O-GLCNACASE NAGJ (protein)
Unique Ligands	CD, NAG

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2YDR \| pdb_00002ydr	Download File View File

CpOGA D298N in complex with p53-derived O-GlcNAc peptide

Schimpl, M., Borodkin, V.S., Gray, L.J., van Aalten, D.M.F.

(2012) Chem Biol 19: 173

Released	2012-03-14
Method	X-RAY DIFFRACTION 2.75 Å
Organisms	Clostridium perfringens Homo sapiens
Macromolecule	CELLULAR TUMOR ANTIGEN P53 (protein) O-GLCNACASE NAGJ (protein)
Unique Ligands	CD, NAG

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2YDS \| pdb_00002yds	Download File View File

CpOGA D298N in complex with TAB1-derived O-GlcNAc peptide

Schimpl, M., Borodkin, V.S., Gray, L.J., van Aalten, D.M.F.

(2012) Chem Biol 19: 173

Released	2012-03-14
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Clostridium perfringens Homo sapiens
Macromolecule	O-GLCNACASE NAGJ (protein) TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1 (protein)
Unique Ligands	CD, NAG

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2YPT \| pdb_00002ypt	Download File View File

Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 mutant (E336A) in complex with a synthetic CSIM tetrapeptide from the C-terminus of prelamin A

Pike, A.C.W., Dong, Y.Y., Quigley, A., Dong, L., Savitsky, P., Cooper, C.D.O., Chaikuad, A., Goubin, S., Shrestha, L., Li, Q., Mukhopadhyay, S., Yang, J., Xia, X., Shintre, C.A., Barr, A.J., Berridge, G., Chalk, R., Bray, J.E., von Delft, F., Bullock, A., Bountra, C., Arrowsmith, C.H., Edwards, A., Burgess-Brown, N., Carpenter, E.P.

(2013) Science 339: 1604

Released	2012-12-05
Method	X-RAY DIFFRACTION 3.8 Å
Organisms	Homo sapiens
Macromolecule	CAAX PRENYL PROTEASE 1 HOMOLOG (protein) PRELAMIN-A/C (protein)
Unique Ligands	ZN

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3GCT \| pdb_00003gct	Download File View File

STRUCTURE OF GAMMA-CHYMOTRYPSIN IN THE RANGE $PH 2.0 TO $PH 10.5 SUGGESTS THAT GAMMA-CHYMOTRYPSIN IS A COVALENT ACYL-ENZYME ADDUCT AT LOW $PH

Dixon, M.M., Matthews, B.W.

(1991) Int J Biol Macromol 13: 89-96

Released	1991-10-15
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Bos taurus
Macromolecule	GAMMA-CHYMOTRYPSIN A (protein) UNK PRO GLY ALA TYR PEPTIDE (protein)
Unique Ligands	SO4

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3OTS \| pdb_00003ots	Download File View File

MDR769 HIV-1 protease complexed with MA/CA hepta-peptide

Liu, Z., Wang, Y., Brunzelle, J., Kovari, I.A., Kovari, L.C.

(2011) Protein J 30: 173-183

Released	2011-03-30
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Human immunodeficiency virus 1
Macromolecule	MA/CA substrate peptide (protein) Multi-drug resistant HIV-1 protease (protein)

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3OTY \| pdb_00003oty	Download File View File

MDR769 HIV-1 protease complexed with RT/RH hepta-peptide

Liu, Z., Wang, Y., Brunzelle, J., Kovari, I.A., Kovari, L.C.

(2011) Protein J 30: 173-183

Released	2011-03-30
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Human immunodeficiency virus 1
Macromolecule	MDR HIV-1 protease (protein) RT/RH substrate peptide (protein)

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3OU1 \| pdb_00003ou1	Download File View File

MDR769 HIV-1 protease complexed with RH/IN hepta-peptide

Liu, Z., Wang, Y., Brunzelle, J., Kovari, I.A., Kovari, L.C.

(2011) Protein J 30: 173-183

Released	2011-03-30
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Human immunodeficiency virus 1
Macromolecule	MDR HIV-1 protease (protein) RH/IN substrate peptide (protein)

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3OU3 \| pdb_00003ou3	Download File View File

MDR769 HIV-1 protease complexed with PR/RT hepta-peptide

Liu, Z., Wang, Y., Brunzelle, J., Kovari, I.A., Kovari, L.C.

(2011) Protein J 30: 173-183

Released	2011-03-30
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Human immunodeficiency virus 1
Macromolecule	HIV-1 protease (protein) PR/RT substrate peptide (protein)

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3OU4 \| pdb_00003ou4	Download File View File

MDR769 HIV-1 protease complexed with TF/PR hepta-peptide

Liu, Z., Wang, Y., Brunzelle, J., Kovari, I.A., Kovari, L.C.

(2011) Protein J 30: 173-183

Released	2011-03-30
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Human immunodeficiency virus 1
Macromolecule	HIV-1 protease (protein) TF/PR substrate peptide (protein)

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3OUA \| pdb_00003oua	Download File View File

MDR769 HIV-1 protease complexed with p1/p6 hepta-peptide

Liu, Z., Wang, Y., Brunzelle, J., Kovari, I.A., Kovari, L.C.

(2011) Protein J 30: 173-183

Released	2011-03-30
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Human immunodeficiency virus 1
Macromolecule	HIV-1 protease (protein) p1/p6 substrate peptide (protein)

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3OUB \| pdb_00003oub	Download File View File

MDR769 HIV-1 protease complexed with NC/p1 hepta-peptide

Liu, Z., Wang, Y., Brunzelle, J., Kovari, I.A., Kovari, L.C.

(2011) Protein J 30: 173-183

Released	2011-03-30
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Human immunodeficiency virus 1
Macromolecule	MDR HIV-1 protease (protein) NC/p1 substrate peptide (protein)

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3OUC \| pdb_00003ouc	Download File View File

MDR769 HIV-1 protease complexed with p2/NC hepta-peptide

Liu, Z., Wang, Y., Brunzelle, J., Kovari, I.A., Kovari, L.C.

(2011) Protein J 30: 173-183

Released	2011-03-30
Method	X-RAY DIFFRACTION 2 Å
Organisms	Human immunodeficiency virus 1
Macromolecule	MDR HIV-1 protease (protein) p2/NC substrate peptide (protein)

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3OUD \| pdb_00003oud	Download File View File

MDR769 HIV-1 protease complexed with CA/p2 hepta-peptide

Liu, Z., Wang, Y., Brunzelle, J., Kovari, I.A., Kovari, L.C.

(2011) Protein J 30: 173-183

Released	2011-03-30
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Human immunodeficiency virus 1
Macromolecule	CA/p2 substrate peptide (protein) MDR HIV-1 protease (protein)

1 to 25 of 75 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

1EJY | pdb_00001ejy

1GCT | pdb_00001gct

1JD5 | pdb_00001jd5

1JD6 | pdb_00001jd6

1YTG | pdb_00001ytg

1YTH | pdb_00001yth

1YTJ | pdb_00001ytj

2GCT | pdb_00002gct

2WV4 | pdb_00002wv4

2WV5 | pdb_00002wv5

2XNS | pdb_00002xns

2YDQ | pdb_00002ydq

2YDR | pdb_00002ydr

2YDS | pdb_00002yds

2YPT | pdb_00002ypt

3GCT | pdb_00003gct

3OTS | pdb_00003ots

3OTY | pdb_00003oty

3OU1 | pdb_00003ou1

3OU3 | pdb_00003ou3

3OU4 | pdb_00003ou4

3OUA | pdb_00003oua

3OUB | pdb_00003oub

3OUC | pdb_00003ouc

3OUD | pdb_00003oud