GDP

GUANOSINE-5'-DIPHOSPHATE

Find entries where: GDP

is present as a standalone ligand in 2,056 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 35 entries

is present in a polymer sequence 37 entries

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Chemical Component Summary
Name	GUANOSINE-5'-DIPHOSPHATE
Identifiers	[(2R,3S,4R,5R)-5-(2-azanyl-6-oxidanylidene-1H-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate
Formula	C₁₀ H₁₅ N₅ O₁₁ P₂
Molecular Weight	443.201
Type	RNA LINKING
Isomeric SMILES	c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
InChI	InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKey	QGWNDRXFNXRZMB-UUOKFMHZSA-N

Chemical Details
Formal Charge	0
Atom Count	43
Chiral Atom Count	4
Bond Count	45
Aromatic Bond Count	5

Drug Info: DrugBank

DrugBank ID	DB04315
Name	Guanosine-5'-Diphosphate
Groups	experimental
Description	A guanine nucleotide containing two phosphate groups esterified to the sugar moiety. [PubChem]
Synonyms	Guanosine-5'-Diphosphate
CAS number	146-91-8

Drug Targets

Name	Target Sequence	Pharmacological Action
GTPase HRas	MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET...	unknown
Transforming protein RhoA	MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDG...	unknown
Protein-glutamine gamma-glutamyltransferase 2	MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNY...	unknown
Ras-related protein Rab-11A	MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFAT...	unknown
Adenylosuccinate synthetase	MGNNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEK...	unknown
Cell division protein FtsZ	MTPPHNYLAVIKVVGIGGGGVNAVNRMIEQGLKGVEFIAINTDAQALLMS...	unknown
Protein-glutamine gamma-glutamyltransferase E	MAALGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQVLMIMNKGLGS...	unknown
Ras-related protein Rab-8B	MAKTYDYLFKLLLIGDSGVGKTCLLFRFSEDAFNTTFISTIGIDFKIRTI...	unknown
ADP-ribosylation factor 6	MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVE...	unknown
Adenylosuccinate synthetase isozyme 1	MSGTRASNDRPPGAGGVKRGRLQQEAAATGSRVTVVLGAQWGDEGKGKVV...	unknown
Elongation factor G	MAVKVEYDLKRLRNIGIAAHIDAGKTTTTERILYYTGRIHKIGEVHEGAA...	unknown
Elongation factor Tu, mitochondrial	MAAATLLRATPHFSGLAAGRTFLLQGLLRLLKAPALPLLCRGLAVEAKKT...	unknown
GTPase Der	MATVLIVGRPNVGKSTLFNKLVKKKKAIVEDEEGVTRDPVQDTVEWYGKT...	unknown
GDP-mannose mannosyl hydrolase	MFLRQEDFATVVRSTPLVSLDFIVENSRGEFLLGKRTNRPAQGYWFVPGG...	unknown
Probable GTP-binding protein EngB	MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLINRKNLA...	unknown
Eukaryotic translation initiation factor 2 subunit 3	MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHV...	unknown
Guanine nucleotide-binding protein G(i) subunit alpha-1	MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIV...	unknown
Signal recognition particle protein	MFQQLSARLQEAIGRLRGRGRITEEDLKATLREIRRALMDADVNLEVARD...	unknown
Guanine nucleotide-binding protein G(t) subunit alpha-1	MGAGASAEEKHSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMK...	unknown
Elongation factor Tu-B	MAKGEFIRTKPHVNVGTIGHVDHGKTTLTAALTFVTAAENPNVEVKDYGD...	unknown
Ras-related protein Rab-9A	MAGKSSLFKVILLGDGGVGKSSLMNRYVTNKFDTQLFHTIGVEFLNKDLE...	unknown
Nucleoside diphosphate kinase A	MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKE...	unknown
GTP-binding protein Rheb	MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVN...	unknown
Cell division control protein 42 homolog	MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEP...	unknown
Elongation factor Tu	MSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGAARAFDQI...	unknown
ADP-ribosylation factor 1	MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIG...	unknown
Elongation factor 2	MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASAR...	unknown
Bifunctional (p)ppGpp synthase/hydrolase RelA	MAKEINLTGEEVVALAAKYMNETDAAFVKKALDYATAAHFYQVRKSGEPY...	unknown
Ras-related protein Rap-2a	MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSP...	unknown
Elongation factor Tu GTP-binding domain-containing protein 1	MVLNSLDKMIQLQKNTANIRNICVLAHVDHGKTTLADCLISSNGIISSRL...	unknown
ADP-ribosylation factor-like protein 1	MGGFFSSIFSSLFGTREMRILILGLDGAGKTTILYRLQVGEVVTTIPTIG...	unknown
GTP-binding nuclear protein Ran	MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPL...	unknown
Ras-related protein Rab-7a	MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEV...	unknown
Interferon-inducible GTPase 5	MATSKLPVVPGEEENTILMAKERLEALRTAFESGDLPQAASHLQELLAST...	unknown
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A	MELSEPIVENGETEMSPEESWEHKEEISEAEPGGGSLGDGRPPEESAHEM...	unknown
Ras-related protein Rab-5A	MASRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQE...	unknown
Elongation factor 1-alpha 1	MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMG...	unknown
ADP-ribosylation factor 4	MGLTISSLFSRLFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIG...	unknown
GDP-mannose 4,6 dehydratase	MAHAPARCPSARGSGDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEV...	unknown
Ras-related protein Ral-A	MAANKPKGQNSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADS...	unknown
Elongation factor Tu	MAKGEFIRTKPHVNVGTIGHVDHGKTTLTAALTYVAAAENPNVEVKDYGD...	unknown
ADP-ribosylation factor-like protein 5B	MGLIFAKLWSLFCNQEHKVIIVGLDNAGKTTILYQFLMNEVVHTSPTIGS...	unknown
GTPase (Rab6)	MDEFQNSGLNKYKLVFLGEQAVGKTSIITRFMYDTFDNNYQSTIGIDFLS...	unknown
ADP-ribosylation factor-like protein 3	MGLLSILRKLKSAPDQEVRILLLGLDNAGKTTLLKQLASEDISHITPTQG...	unknown
Nucleoside diphosphate kinase B	MANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQ...	unknown
GDP-mannose 4,6-dehydratase	MTRSALVTGITGQDGAYLAKLLLEKGYRVHGLVARRSSDTRWRLRELGIE...	unknown
Ras-related C3 botulinum toxin substrate 1	MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKP...	unknown
Putative ribosome biogenesis GTPase RsgA	MNLRRRGIVVSFHSNMVTVEDEETGERILCKLRGKFRLQNLKIYVGDRVE...	unknown
GTP-binding protein SAR1b	MSFIFDWIYSGFSSVLQFLGLYKKTGKLVFLGLDNAGKTTLLHMLKDDRL...	unknown
Adenylosuccinate synthetase	MNIFDHQIKNVDKGNVVAILGAQWGDEGKGKIIDMLSEYSDITCRFNGGA...	unknown
ADP-ribosylation factor-like protein 5A	MGILFTRIWRLFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGS...	unknown
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682