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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Enzyme Classification Number = 3.4.22

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Search Summary

This query matches 19 Structures.

Refinements

Structure Determination Methodology

experimental (19)

Scientific Name of Source Organism

	Pseudomonas aeruginosa (12)
	Pseudomonas aeruginosa UCBPP-PA14 (6)
	Pseudomonas (5)
	Casadabanvirus D3112 (2)
	Proteus penneri (2)
	Escherichia (1)
	Pseudomonas phage JBD30 (1)
	Shewanella xiamenensis (1)
	synthetic construct (1)
	unidentified (1)

Taxonomy

	Bacteria (19)
	Duplodnaviria (2)
	other sequences (1)
	unclassified sequences (1)

Experimental Method

ELECTRON MICROSCOPY (19)

Polymer Entity Type

	Protein (19)
	RNA (19)
	DNA (6)

Refinement Resolution (Å)

	2.5 - 3.0 (4)
	3.0 - 3.5 (8)
	3.5 - 4.0 (6)
	4.0 - 4.5 (1)

Release Date

	2015 - 2019 (6)
	2020 - 2024 (13)

Enzyme Classification Name

Hydrolases (19)

Symmetry Type

	Asymmetric (16)
	Cyclic (3)

SCOP Classification

Alpha and beta proteins (a+b) (2)

AllSelected

1 to 19 of 19 Structures

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5UZ9 \| pdb_00005uz9	Download File View File

Cryo EM structure of anti-CRISPRs, AcrF1 and AcrF2, bound to type I-F crRNA-guided CRISPR surveillance complex

Chowdhury, S., Carter, J., Rollins, M.F., Jackson, R.N., Hoffmann, C., Nosaka, L., Bondy-Denomy, J., Maxwell, K.L., Davidson, A.R., Fischer, E.R., Lander, G.C., Wiedenheft, B.

(2017) Cell 169: 47-57.e11

Released	2017-04-26
Method	ELECTRON MICROSCOPY 3.4 Å
Organisms	Casadabanvirus D3112 Pseudomonas aeruginosa UCBPP-PA14 Pseudomonas phage JBD30
Macromolecule	Unique protein chains: 6 Unique nucleic acid chains: 1

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6B44 \| pdb_00006b44	Download File View File

Cryo-EM structure of Type I-F CRISPR crRNA-guided Csy surveillance complex with bound target dsDNA

Guo, T.W., Bartesaghi, A., Yang, H., Falconieri, V., Rao, P., Merk, A., Fox, T., Earl, L., Patel, D.J., Subramaniam, S.

(2017) Cell 171: 414-426.e12

Released	2017-10-18
Method	ELECTRON MICROSCOPY 2.9 Å
Organisms	Pseudomonas aeruginosa Pseudomonas aeruginosa UCBPP-PA14 synthetic construct
Macromolecule	Unique protein chains: 4 Unique nucleic acid chains: 3

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6B45 \| pdb_00006b45	Download File View File

Cryo-EM structure of Type I-F CRISPR crRNA-guided Csy surveillance complex

Guo, T.W., Bartesaghi, A., Yang, H., Falconieri, V., Rao, P., Merk, A., Fox, T., Earl, L., Patel, D.J., Subramaniam, S.

(2017) Cell 171: 414-426.e12

Released	2017-10-18
Method	ELECTRON MICROSCOPY 3.5 Å
Organisms	Pseudomonas aeruginosa Pseudomonas aeruginosa UCBPP-PA14
Macromolecule	CRISPR-associated endonuclease Cas6/Csy4 (protein) CRISPR-associated protein Csy1 (protein) CRISPR-associated protein Csy2 (protein) CRISPR-associated protein Csy3 (protein) Pseudomonas aeruginosa strain SMC4485 CRISPR repeat sequence (nucleic acid)

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6B47 \| pdb_00006b47	Download File View File

Cryo-EM structure of Type I-F CRISPR crRNA-guided Csy surveillance complex with bound anti-CRISPR protein AcrF2

Guo, T.W., Bartesaghi, A., Yang, H., Falconieri, V., Rao, P., Merk, A., Fox, T., Earl, L., Patel, D.J., Subramaniam, S.

(2017) Cell 171: 414-426.e12

Released	2017-10-18
Method	ELECTRON MICROSCOPY 3.2 Å
Organisms	Casadabanvirus D3112 Pseudomonas aeruginosa Pseudomonas aeruginosa UCBPP-PA14
Macromolecule	Unique protein chains: 5 Unique nucleic acid chains: 1

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6B48 \| pdb_00006b48	Download File View File

Cryo-EM structure of Type I-F CRISPR crRNA-guided Csy surveillance complex with bound anti-CRISPR protein AcrF10

Guo, T.W., Bartesaghi, A., Yang, H., Falconieri, V., Rao, P., Merk, A., Fox, T., Earl, L., Patel, D.J., Subramaniam, S.

(2017) Cell 171: 414-426.e12

Released	2017-10-18
Method	ELECTRON MICROSCOPY 3.6 Å
Organisms	Pseudomonas aeruginosa Pseudomonas aeruginosa UCBPP-PA14 Shewanella xiamenensis
Macromolecule	Unique protein chains: 5 Unique nucleic acid chains: 1

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6NE0 \| pdb_00006ne0	Download File View File

Structure of double-stranded target DNA engaged Csy complex from Pseudomonas aeruginosa (PA-14)

Chowdhury, S., Rollins, M.F., Carter, J., Golden, S.M., Miettinen, H.M., Santiago-Frangos, A., Faith, D., Lawrence, M.C., Wiedenheft, B., Lander, G.C.

(2019) Mol Cell 74: 132-142.e5

Released	2018-12-26
Method	ELECTRON MICROSCOPY 3.4 Å
Organisms	Pseudomonas aeruginosa UCBPP-PA14
Macromolecule	Unique protein chains: 4 Unique nucleic acid chains: 3

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6VQV \| pdb_00006vqv	Download File View File

Type I-F CRISPR-Csy complex with its inhibitor AcrF9

Zhang, K., Li, S., Pintilie, G., Zhu, Y., Huang, Z., Chiu, W.

(2020) Proc Natl Acad Sci U S A 117: 7176-7182

Released	2020-03-11
Method	ELECTRON MICROSCOPY 2.57 Å
Organisms	Pseudomonas aeruginosa
Macromolecule	Unique protein chains: 5 Unique nucleic acid chains: 1

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6VQW \| pdb_00006vqw	Download File View File

Type I-F CRISPR-Csy complex with its inhibitor AcrF8

Zhang, K., Li, S., Pintilie, G., Zhu, Y., Huang, Z., Chiu, W.

(2020) Proc Natl Acad Sci U S A 117: 7176-7182

Released	2020-03-11
Method	ELECTRON MICROSCOPY 3.42 Å
Organisms	Pseudomonas aeruginosa
Macromolecule	Unique protein chains: 5 Unique nucleic acid chains: 1

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6VQX \| pdb_00006vqx	Download File View File

Type I-F CRISPR-Csy complex with its inhibitor AcrF6

Zhang, K., Li, S., Pintilie, G., Zhu, Y., Huang, Z., Chiu, W.

(2020) Proc Natl Acad Sci U S A 117: 7176-7182

Released	2020-03-11
Method	ELECTRON MICROSCOPY 3.15 Å
Organisms	Pseudomonas aeruginosa
Macromolecule	Unique protein chains: 5 Unique nucleic acid chains: 1

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6W1X \| pdb_00006w1x	Download File View File

Cryo-EM structure of anti-CRISPR AcrIF9, bound to the type I-F crRNA-guided CRISPR surveillance complex

Hirschi, M., Santiago-Frangos, A., Wilkinson, R., Golden, S.M., Wiedenheft, B., Lander, G.

(2020) Nat Commun 11: 2730-2730

Released	2020-05-13
Method	ELECTRON MICROSCOPY 3.9 Å
Organisms	Proteus penneri Pseudomonas aeruginosa
Macromolecule	Unique protein chains: 5 Unique nucleic acid chains: 1

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6WHI \| pdb_00006whi	Download File View File

Cryo-electron microscopy structure of the type I-F CRISPR RNA-guided surveillance complex bound to the anti-CRISPR AcrIF9

Hirschi, M., Santiago-Frangos, A., Wilkinson, R., Golden, S.M., Wiedenheft, B., Lander, G.

(2020) Nat Commun 11: 2730-2730

Released	2020-05-13
Method	ELECTRON MICROSCOPY 4.2 Å
Organisms	Proteus penneri Pseudomonas aeruginosa
Macromolecule	Unique protein chains: 5 Unique nucleic acid chains: 3

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7JZX \| pdb_00007jzx	Download File View File

Cryo-EM structure of CRISPR-Cas surveillance complex with AcrIF7

Chang, L., Li, Z., Gabel, C.

(2021) Nucleic Acids Res 49: 584-594

Released	2020-12-30
Method	ELECTRON MICROSCOPY 3.4 Å
Organisms	Pseudomonas aeruginosa
Macromolecule	Unique protein chains: 5 Unique nucleic acid chains: 1

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7JZY \| pdb_00007jzy	Download File View File

CryoEM structure of a CRISPR-Cas complex

Chang, L., Li, Z., Gabel, C.

To be published

Released	2021-09-22
Method	ELECTRON MICROSCOPY 3.6 Å
Organisms	Pseudomonas aeruginosa
Macromolecule	Unique protein chains: 5 Unique nucleic acid chains: 1

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7JZZ \| pdb_00007jzz	Download File View File

Cryo-EM structure of CRISPR-Cas surveillance complex with AcrIF14

Chang, L., Li, Z., Gabel, C.

(2021) Nucleic Acids Res 49: 584-594

Released	2020-12-30
Method	ELECTRON MICROSCOPY 3.2 Å
Organisms	Pseudomonas aeruginosa unidentified
Macromolecule	Unique protein chains: 5 Unique nucleic acid chains: 1