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234,440 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Enzyme Classification Number = 3.1.1.98

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Search Summary

This query matches 142 Structures.

Refinements

Structure Determination Methodology

experimental (142)

Scientific Name of Source Organism

	Homo sapiens (140)
	Drosophila melanogaster (2)

Taxonomy

Eukaryota (142)

Experimental Method

X-RAY DIFFRACTION (142)

Polymer Entity Type

Protein (142)

Refinement Resolution (Å)

	1.0 - 1.5 (65)
	1.5 - 2.0 (60)
	2.0 - 2.5 (16)
	2.5 - 3.0 (1)

Release Date

	2015 - 2019 (17)
	2020 - 2024 (125)

Enzyme Classification Name

Hydrolases (142)

Symmetry Type

	Asymmetric (138)
	Cyclic (4)

SCOP Classification

	Alpha and beta proteins (a/b) (36)
	Artifacts (10)

AllSelected

1 to 25 of 142 Structures

Page 1 of 6

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4UYU \| pdb_00004uyu	Download File View File

STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM I IODIDE COMPLEX - 2.3A

Zebisch, M., Jones, E.Y.

(2015) Nature 519: 187

Released	2015-02-25
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN NOTUM HOMOLOG (protein)
Unique Ligands	CL, IOD, NAG

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4UYW \| pdb_00004uyw	Download File View File

STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM I HEPARIN FRAGMENT COMPLEX - 1.7A

Zebisch, M., Jones, E.Y.

(2015) Nature 519: 187

Released	2015-02-25
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN NOTUM HOMOLOG (protein)
Unique Ligands	NAG
Unique branched monosaccharides	SGN, UAP

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4UYZ \| pdb_00004uyz	Download File View File

STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM II - 2.8A

Zebisch, M., Jones, E.Y.

(2015) Nature 519: 187

Released	2015-02-25
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	POLY ALA (protein) PROTEIN NOTUM HOMOLOG (protein)
Unique Ligands	CL, NAG

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4UZ1 \| pdb_00004uz1	Download File View File

STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM III - 1.4A

Zebisch, M., Jones, E.Y.

(2015) Nature 519: 187

Released	2015-02-25
Method	X-RAY DIFFRACTION 1.4 Å
Organisms	Homo sapiens
Macromolecule	NOTUM (protein)
Unique Ligands	NAG, SO4

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4UZ5 \| pdb_00004uz5	Download File View File

STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM IV - 2.1A

Zebisch, M., Jones, E.Y.

(2015) Nature 519: 187

Released	2015-02-25
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	NOTUM (protein)
Unique Ligands	CL, NAG

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4UZ6 \| pdb_00004uz6	Download File View File

STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM V - SOS COMPLEX - 1.9A

Zebisch, M., Jones, E.Y.

(2015) Nature 519: 187

Released	2015-02-25
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN NOTUM HOMOLOG (protein)
Unique Ligands	CL, NAG
Unique branched monosaccharides	GU4, YYJ

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4UZ7 \| pdb_00004uz7	Download File View File

STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM VI - 2.2A

Zebisch, M., Jones, E.Y.

(2015) Nature 519: 187

Released	2015-02-25
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN NOTUM HOMOLOG (protein)
Unique Ligands	CL

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4UZ9 \| pdb_00004uz9	Download File View File

STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM VII - SOS COMPLEX - 2.2A

Zebisch, M., Jones, E.Y.

(2015) Nature 519: 187

Released	2015-02-25
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN NOTUM HOMOLOG (protein)
Unique Ligands	CL, NAG
Unique branched monosaccharides	GU4, YYJ

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4UZA \| pdb_00004uza	Download File View File

STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM VIII - PHOSPHATE COMPLEX - 2.4A

Zebisch, M., Jones, E.Y.

(2015) Nature 519: 187

Released	2015-02-25
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN NOTUM HOMOLOG (protein)
Unique Ligands	NAG, PO4

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4UZJ \| pdb_00004uzj	Download File View File

STRUCTURE OF THE WNT DEACYLASE NOTUM FROM DROSOPHILA - CRYSTAL FORM I - 2.4A

Zebisch, M., Jones, E.Y.

(2015) Nature 519: 187

Released	2015-02-25
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Drosophila melanogaster
Macromolecule	NOTUM (protein)
Unique Ligands	NAG

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4UZK \| pdb_00004uzk	Download File View File

STRUCTURE OF THE WNT DEACYLASE NOTUM FROM DROSOPHILA - CRYSTAL FORM II - 1.9A

Zebisch, M., Jones, E.Y.

(2015) Nature 519: 187

Released	2015-02-25
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Drosophila melanogaster
Macromolecule	NOTUM (protein)
Unique Ligands	NAG

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4UZL \| pdb_00004uzl	Download File View File

STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM I MYRISTOLEATE COMPLEX - 2.1A

Zebisch, M., Jones, E.Y.

(2015) Nature 519: 187

Released	2015-02-25
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN NOTUM HOMOLOG (protein)
Unique Ligands	MYZ, NAG

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4UZQ \| pdb_00004uzq	Download File View File

STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH O-PALMITOLEOYL SERINE - CRYSTAL FORM IX - 1.5A

Zebisch, M., Jones, E.Y.

(2015) Nature 519: 187

Released	2015-02-25
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN NOTUM HOMOLOG (protein) PROTEIN WNT-7A (protein)
Unique Ligands	CL, NA, NAG, PAM

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4WBH \| pdb_00004wbh	Download File View File

STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM I APO - 2.2A

Zebisch, M., Jones, E.Y.

(2015) Nature 519: 187-192

Released	2015-02-25
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Protein notum homolog (protein)
Unique Ligands	CL, NAG, SO4

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6R8P \| pdb_00006r8p	Download File View File

Notum fragment 723

Zhao, Y., Jones, E.Y.

(2019) Medchemcomm 10: 1361-1369

Released	2019-05-08
Method	X-RAY DIFFRACTION 1.45 Å
Organisms	Homo sapiens
Macromolecule	Palmitoleoyl-protein carboxylesterase NOTUM (protein)
Unique Ligands	DMS, GOL, JVB, NAG, SO4

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6R8Q \| pdb_00006r8q	Download File View File

STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A BENZOTRIAZOLE FRAGMENT

Ruza, R.R., Vecchia, L., Jones, E.Y.

(2019) Medchemcomm 10: 1361-1369

Released	2019-05-08
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	Palmitoleoyl-protein carboxylesterase NOTUM (protein)
Unique Ligands	EDO, JV5, NAG, SO4

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6R8R \| pdb_00006r8r	Download File View File

Structure of the Wnt deacylase Notum in complex with isoquinoline 45

Vecchia, L., Zhao, Y., Ruza, R.R., Jones, E.Y.

(2019) Medchemcomm 10: 1361-1369

Released	2019-05-08
Method	X-RAY DIFFRACTION 1.27 Å
Organisms	Homo sapiens
Macromolecule	Palmitoleoyl-protein carboxylesterase NOTUM (protein)
Unique Ligands	DMS, EDO, JV8, NAG, SO4

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6T2H \| pdb_00006t2h	Download File View File

Furano[2,3-d]prymidine amides as Notum inhibitors

Zhao, Y., Jones, E.Y.

(2020) Bioorg Med Chem Lett 30: 126751-126751

Released	2020-01-01
Method	X-RAY DIFFRACTION 1.41 Å
Organisms	Homo sapiens
Macromolecule	Palmitoleoyl-protein carboxylesterase NOTUM (protein)
Unique Ligands	DMS, EDO, M9N, NAG, SO4

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6T2K \| pdb_00006t2k	Download File View File

Furano[2,3-d]prymidine amides as Notum inhibitors

Zhao, Y., Jones, E.Y.

(2020) Bioorg Med Chem Lett 30: 126751-126751

Released	2020-01-01
Method	X-RAY DIFFRACTION 1.38 Å
Organisms	Homo sapiens
Macromolecule	Palmitoleoyl-protein carboxylesterase NOTUM (protein)
Unique Ligands	EDO, M9K, NAG, SO4

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6TR5 \| pdb_00006tr5	Download File View File

Melatonin-Notum complex

Zhao, Y., Jones, E.Y.

(2020) J Pineal Res 68: e12630-e12630

Released	2020-01-15
Method	X-RAY DIFFRACTION 1.509 Å
Organisms	Homo sapiens
Macromolecule	Palmitoleoyl-protein carboxylesterase NOTUM (protein)
Unique Ligands	DMS, ML1, NAG, SO4

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6TR6 \| pdb_00006tr6	Download File View File

N-acetylserotonin-Notum complex

Zhao, Y., Jones, E.Y.

(2020) J Pineal Res 68: e12630-e12630

Released	2020-01-08
Method	X-RAY DIFFRACTION 1.35 Å
Organisms	Homo sapiens
Macromolecule	Palmitoleoyl-protein carboxylesterase NOTUM (protein)
Unique Ligands	ASE, DMS, EDO, NAG, SO4

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6TR7 \| pdb_00006tr7	Download File View File

N-[2-(5-fluoro-1H-indol-3-yl)ethyl]acetamide-Notum complex

Zhao, Y., Jones, E.Y.

(2020) J Pineal Res 68: e12630-e12630

Released	2020-01-08
Method	X-RAY DIFFRACTION 1.47 Å
Organisms	Homo sapiens
Macromolecule	Palmitoleoyl-protein carboxylesterase NOTUM (protein)
Unique Ligands	EDO, HWH, NAG, SO4

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6TUZ \| pdb_00006tuz	Download File View File

Theophylline-Notum complex

Zhao, Y., Jones, E.Y.

(2020) Commun Biol 3: 555-555

Released	2020-10-28
Method	X-RAY DIFFRACTION 1.24 Å
Organisms	Homo sapiens
Macromolecule	Palmitoleoyl-protein carboxylesterase NOTUM (protein)
Unique Ligands	DMS, EDO, NAG, SO4, TEP

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6TV4 \| pdb_00006tv4	Download File View File

CFF-Notum complex

Zhao, Y., Jones, E.Y.

(2020) Commun Biol 3: 555-555

Released	2020-10-28
Method	X-RAY DIFFRACTION 1.53 Å
Organisms	Homo sapiens
Macromolecule	Palmitoleoyl-protein carboxylesterase NOTUM (protein)
Unique Ligands	CFF, DMS, GOL, NAG, SO4

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6YSK \| pdb_00006ysk	Download File View File

1-phenylpyrroles and 1-enylpyrrolidines as inhibitors of Notum

Zhao, Y., Jones, E.Y., Fish, P.

(2020) J Med Chem 63: 9464-9483

Released	2020-09-16
Method	X-RAY DIFFRACTION 1.21 Å
Organisms	Homo sapiens
Macromolecule	Palmitoleoyl-protein carboxylesterase NOTUM (protein)
Unique Ligands	DMS, EDO, NAG, PJK, SO4

1 to 25 of 142 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

4UYU | pdb_00004uyu

4UYW | pdb_00004uyw

4UYZ | pdb_00004uyz

4UZ1 | pdb_00004uz1

4UZ5 | pdb_00004uz5

4UZ6 | pdb_00004uz6

4UZ7 | pdb_00004uz7

4UZ9 | pdb_00004uz9

4UZA | pdb_00004uza

4UZJ | pdb_00004uzj

4UZK | pdb_00004uzk

4UZL | pdb_00004uzl

4UZQ | pdb_00004uzq

4WBH | pdb_00004wbh

6R8P | pdb_00006r8p

6R8Q | pdb_00006r8q

6R8R | pdb_00006r8r

6T2H | pdb_00006t2h

6T2K | pdb_00006t2k

6TR5 | pdb_00006tr5

6TR6 | pdb_00006tr6

6TR7 | pdb_00006tr7

6TUZ | pdb_00006tuz

6TV4 | pdb_00006tv4

6YSK | pdb_00006ysk