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234,440 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Schwarz, D."

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Search Summary

This query matches 39 Structures.

Refinements

Structure Determination Methodology

experimental (39)

Scientific Name of Source Organism

	Homo sapiens (34)
	Saccharomyces cerevisiae S288C (4)
	Mus musculus (2)
	Spodoptera frugiperda (2)

Taxonomy

Eukaryota (39)

Experimental Method

	X-RAY DIFFRACTION (37)
	ELECTRON MICROSCOPY (2)

Polymer Entity Type

Protein (39)

Refinement Resolution (Å)

	0.5 - 1.0 (1)
	1.0 - 1.5 (7)
	1.5 - 2.0 (7)
	2.0 - 2.5 (12)
	2.5 - 3.0 (5)
	3.0 - 3.5 (5)
	4.0 - 4.5 (1)
	> 4.5 (1)

Release Date

	2005 - 2009 (1)
	2010 - 2014 (8)
	2015 - 2019 (21)
	2020 - 2024 (8)
	2025 - 2029 (1)

Enzyme Classification Name

	Transferases (17)
	Lyases (5)
	Isomerases (7)
	Hydrolases (5)

Membrane Protein Annotation

OPM (1)

Symmetry Type

	Asymmetric (32)
	Cyclic (9)

SCOP Classification

	All beta proteins (12)
	Alpha and beta proteins (a+b) (1)
	Alpha and beta proteins (a/b) (1)

AllSelected

1 to 25 of 39 Structures

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2YMY \| pdb_00002ymy	Download File View File

Structure of the murine Nore1-Sarah domain

Makbul, C., Schwarz, D., Aruxandei, D.C., Wolf, E., Hofmann, E., Herrmann, C.

(2013) Biochemistry 52: 1045

Released	2013-03-20
Method	X-RAY DIFFRACTION 1.69 Å
Organisms	Mus musculus
Macromolecule	RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 5 (protein)
Unique Ligands	CD

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3DDC \| pdb_00003ddc	Download File View File

Crystal Structure of NORE1A in Complex with RAS

Stieglitz, B., Bee, C., Schwarz, D., Yildiz, O., Moshnikova, A., Khokhlatchev, A., Herrmann, C.

(2008) EMBO J 27: 1995-2005

Released	2008-07-15
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	GTPase HRas (protein) Ras association domain-containing family protein 5 (protein)
Unique Ligands	GNP, MG

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3SJA \| pdb_00003sja	Download File View File

Crystal structure of S. cerevisiae Get3 in the open state in complex with Get1 cytosolic domain

Reitz, S., Wild, K., Sinning, I.

(2011) Science 333: 758-762

Released	2011-07-06
Method	X-RAY DIFFRACTION 3 Å
Organisms	Saccharomyces cerevisiae S288C
Macromolecule	ATPase GET3 (protein) Golgi to ER traffic protein 1 (protein)
Unique Ligands	PO4, ZN

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3SJB \| pdb_00003sjb	Download File View File

Crystal structure of S. cerevisiae Get3 in the open state in complex with Get1 cytosolic domain

Reitz, S., Wild, K., Sinning, I.

(2011) Science 333: 758-762

Released	2011-07-06
Method	X-RAY DIFFRACTION 3.3 Å
Organisms	Saccharomyces cerevisiae S288C
Macromolecule	ATPase GET3 (protein) Golgi to ER traffic protein 1 (protein)
Unique Ligands	PO4, ZN

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3SJC \| pdb_00003sjc	Download File View File

Crystal structure of S.cerevisiae Get3 in the semi-open state in complex with Get1 cytosolic domain

Reitz, S., Wild, K., Sinning, I.

(2011) Science 333: 758-762

Released	2011-07-06
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Saccharomyces cerevisiae S288C
Macromolecule	ATPase GET3 (protein) Golgi to ER traffic protein 1 (protein)
Unique Ligands	ZN

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3SJD \| pdb_00003sjd	Download File View File

Crystal structure of S. cerevisiae Get3 with bound ADP-Mg2+ in complex with Get2 cytosolic domain

Reitz, S., Wild, K., Sinning, I.

(2011) Science 333: 758-762

Released	2011-07-13
Method	X-RAY DIFFRACTION 4.6 Å
Organisms	Saccharomyces cerevisiae S288C
Macromolecule	ATPase GET3 (protein) Golgi to ER traffic protein 2 (protein)
Unique Ligands	ADP, MG, ZN

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4FL1 \| pdb_00004fl1	Download File View File

Structural and Biophysical Characterization of the Syk Activation Switch

Graedler, U., Schwarz, D., Dresing, V., Musil, M., Bomke, J., Frech, M., Jaekel, S., Rysiok, T., Mueller-Pompalla, D., Wegener, A.

(2013) J Mol Biology 425: 309-333

Released	2012-11-28
Method	X-RAY DIFFRACTION 1.79 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase SYK (protein)
Unique Ligands	ANP, MG

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4FL2 \| pdb_00004fl2	Download File View File

Structural and Biophysical Characterization of the Syk Activation Switch

Graedler, U., Schwarz, D., Dresing, V., Musil, M., Bomke, J., Frech, M., Jaekel, S., Rysiok, T., Mueller-Pompalla, D., Wegener, A.

(2013) J Mol Biology 425: 309-333

Released	2012-11-28
Method	X-RAY DIFFRACTION 2.19 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase SYK (protein)
Unique Ligands	ANP, MG

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4FL3 \| pdb_00004fl3	Download File View File

Structural and Biophysical Characterization of the Syk Activation Switch

Graedler, U., Schwarz, D., Dresing, V., Musil, M., Bomke, J., Frech, M., Jaekel, S., Rysiok, T., Mueller-Pompalla, D., Wegener, A.

(2013) J Mol Biology 425: 309-333

Released	2012-11-28
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase SYK (protein)
Unique Ligands	ANP, MG

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4YX4 \| pdb_00004yx4	Download File View File

Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (1).

Rechlin, C., Heine, A., Klebe, G.

(2016) J Med Chem 59: 4245-4256

Released	2016-02-03
Method	X-RAY DIFFRACTION 1.01 Å
Organisms	Homo sapiens
Macromolecule	Carbonic anhydrase 2 (protein)
Unique Ligands	FB2, GOL, MBO, ZN

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4YXI \| pdb_00004yxi	Download File View File

Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (2).

Rechlin, C., Heine, A., Klebe, G.

(2016) J Med Chem 59: 4245-4256

Released	2016-02-03
Method	X-RAY DIFFRACTION 0.96 Å
Organisms	Homo sapiens
Macromolecule	Carbonic anhydrase 2 (protein)
Unique Ligands	4J8, GOL, MBO, ZN

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4YXO \| pdb_00004yxo	Download File View File

Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (3).

Rechlin, C., Heine, A., Klebe, G.

(2016) J Med Chem 59: 4245-4256

Released	2016-02-03
Method	X-RAY DIFFRACTION 1.06 Å
Organisms	Homo sapiens
Macromolecule	Carbonic anhydrase 2 (protein)
Unique Ligands	4JC, GOL, MBO, ZN

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4YXU \| pdb_00004yxu	Download File View File

Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (4).

Rechlin, C., Heine, A., Klebe, G.

(2016) J Med Chem 59: 4245-4256

Released	2016-02-03
Method	X-RAY DIFFRACTION 1.08 Å
Organisms	Homo sapiens
Macromolecule	Carbonic anhydrase 2 (protein)
Unique Ligands	4JE, GOL, MBO, ZN

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4YYT \| pdb_00004yyt	Download File View File

Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (5).

Rechlin, C., Heine, A., Klebe, G.

(2016) J Med Chem 59: 4245-4256

Released	2016-02-03
Method	X-RAY DIFFRACTION 1.07 Å
Organisms	Homo sapiens
Macromolecule	Carbonic anhydrase 2 (protein)
Unique Ligands	GOL, MBO, S2O, ZN

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5BNJ \| pdb_00005bnj	Download File View File

CDK8/CYCC IN COMPLEX WITH 8-{3-Chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)-phenyl]-pyridin- 4-yl}-2,8-diaza-spiro[4.5]decan-1-one

Musil, D., Blagg, J., Wienke, D.

(2015) Nat Chem Biol 11: 973-980

Released	2015-10-14
Method	X-RAY DIFFRACTION 2.64 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-C (protein) Cyclin-dependent kinase 8 (protein)
Unique Ligands	4TV, FMT

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5FGK \| pdb_00005fgk	Download File View File

CDK8-CYCC IN COMPLEX WITH 8-[3-(3-Amino-1H-indazol-6-yl)-5-chloro- pyridine-4-yl]-2,8-diaza-spiro[4.5]decan-1-one

Musil, D., Blagg, J., Mallinger, A.

(2016) J Med Chem 59: 1078-1101

Released	2016-02-03
Method	X-RAY DIFFRACTION 2.36 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-C (protein) Cyclin-dependent kinase 8 (protein)
Unique Ligands	5XG, DMS, EDO, FMT

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5HBE \| pdb_00005hbe	Download File View File

CDK8-CYCC IN COMPLEX WITH 8-[3-Chloro-5-(1-methyl-2,2-dioxo-2, 3-dihydro-1H-2l6-benzo[c]isothiazol-5-yl)-pyridin- 4-yl]-1-oxa-3,8-diaza-spiro[4.5]decan-2-one

Musil, D., Blagg, J., Mallinger, A.

(2016) J Med Chem 59: 1078-1101

Released	2016-02-03
Method	X-RAY DIFFRACTION 2.38 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-C (protein) Cyclin-dependent kinase 8 (protein)
Unique Ligands	5Y6, DMS, EDO, FMT

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5HBH \| pdb_00005hbh	Download File View File

CDK8-CYCC IN COMPLEX WITH 5-{5-Chloro-4-[1-(2-methoxy-ethyl)-1,8-diaza-spiro[4.5]dec-8-yl]-pyridin-3-yl}-1-methyl-1,3-dihydro-benzo[c]isothiazole 2,2-dioxide

Musil, D., Blagg, J., Mallinger, A.

(2016) J Med Chem 59: 1078-1101

Released	2016-02-03
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-C (protein) Cyclin-dependent kinase 8 (protein)
Unique Ligands	5Y7, EDO, FMT

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5HBJ \| pdb_00005hbj	Download File View File

CDK8-CYCC IN COMPLEX WITH 8-[2-Amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)-pyridin-4-yl]-2,8-diaza-spiro[4.5]decan-1-one

Musil, D., Blagg, J., Mallinger, A.

(2016) J Med Chem 59: 1078-1101

Released	2016-02-03
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-C (protein) Cyclin-dependent kinase 8 (protein)
Unique Ligands	5Y8, EDO, FMT

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5I5Z \| pdb_00005i5z	Download File View File

CDK8-CYCC IN COMPLEX WITH 8-(1-Methyl-2,2-dioxo-2,3-dihydro-1H-2l6-benzo[c]isothiazol-5-yl)-[1,6]naphthyridine-2-carboxylic acid methylamide

Musil, D., Blagg, J., Mallinger, A.

(2016) ACS Med Chem Lett 7: 573-578

Released	2016-04-13
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-C (protein) Cyclin-dependent kinase 8 (protein)
Unique Ligands	68U, FMT

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5ICP \| pdb_00005icp	Download File View File

CDK8-CYCC IN COMPLEX WITH [(S)-2-(4-Chloro-phenyl)-pyrrolidin-1-yl]-(5-methyl-imidazo[5,1-b][1,3,4]thiadiazol-2-yl)-methanone

Musil, D., Blagg, J., Mallinger, A., Czodrowski, P., Schiemann, K.

(2016) J Med Chem 59: 9337-9349

Released	2016-12-21
Method	X-RAY DIFFRACTION 2.18 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-C (protein) Cyclin-dependent kinase 8 (protein)
Unique Ligands	69Z, EDO, FMT

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5IDN \| pdb_00005idn	Download File View File

CDK8-CYCC IN COMPLEX WITH [(S)-2-(4-Chloro-phenyl)-pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-methanone

Musil, D., Blagg, J., Mallinger, A., Czodrowski, P., Schiemann, K.

(2016) J Med Chem 59: 9337-9349

Released	2016-12-21
Method	X-RAY DIFFRACTION 2.26 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-C (protein) Cyclin-dependent kinase 8 (protein)
Unique Ligands	6A7, EDO, FMT

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5IDP \| pdb_00005idp	Download File View File

CDK8-CYCC IN COMPLEX WITH (3-Amino-1H-indazol-5-yl)-[(S)-2-(4-fluoro-phenyl)-piperidin-1-yl]-methanone

Musil, D., Blagg, J., Mallinger, A., Czodrowski, P., Schiemann, K.

(2016) J Med Chem 59: 9337-9349

Released	2016-12-21
Method	X-RAY DIFFRACTION 2.65 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-C (protein) Cyclin-dependent kinase 8 (protein)
Unique Ligands	6A6, FMT

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6R8L \| pdb_00006r8l	Download File View File

Human Cyclophilin D in complex with 1-((1S,9S,10S)-10-Hydroxy-12-oxa-8-aza-tricyclo[7.3.1.02,7]trideca-2,4,6-trien-4-ylmethyl)-3- {2-[(R)-2-(2-methylsulfanyl-phenyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-urea

Graedler, U.

(2019) Bioorg Med Chem Lett 29: 126717-126717

Released	2019-11-27
Method	X-RAY DIFFRACTION 1.64 Å
Organisms	Homo sapiens
Macromolecule	Peptidyl-prolyl cis-trans isomerase F, mitochondrial (protein)
Unique Ligands	JUZ

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6R8O \| pdb_00006r8o	Download File View File

Human Cyclophilin D in complex with 1-(((2R,3S,6R)-3-hydroxy-2,3,4,6-tetrahydro-1H-2,6-methanobenzo[c][1,5]oxazocin-8-yl)methyl)-3-(2-((R)-2-(2-(methylthio)phenyl)pyrrolidin-1-yl)-2-oxoethyl)urea

Graedler, U.

(2019) Bioorg Med Chem Lett 29: 126717-126717

Released	2019-11-27
Method	X-RAY DIFFRACTION 1.36 Å
Organisms	Homo sapiens
Macromolecule	Peptidyl-prolyl cis-trans isomerase F, mitochondrial (protein)
Unique Ligands	JV2, PG4, PO4, SO4

1 to 25 of 39 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

2YMY | pdb_00002ymy

3DDC | pdb_00003ddc

3SJA | pdb_00003sja

3SJB | pdb_00003sjb

3SJC | pdb_00003sjc

3SJD | pdb_00003sjd

4FL1 | pdb_00004fl1

4FL2 | pdb_00004fl2

4FL3 | pdb_00004fl3

4YX4 | pdb_00004yx4

4YXI | pdb_00004yxi

4YXO | pdb_00004yxo

4YXU | pdb_00004yxu

4YYT | pdb_00004yyt

5BNJ | pdb_00005bnj

5FGK | pdb_00005fgk

5HBE | pdb_00005hbe

5HBH | pdb_00005hbh

5HBJ | pdb_00005hbj

5I5Z | pdb_00005i5z

5ICP | pdb_00005icp

5IDN | pdb_00005idn

5IDP | pdb_00005idp

6R8L | pdb_00006r8l

6R8O | pdb_00006r8o