RCSB PDB: Search

2XN4 \| pdb_00002xn4	Download File View File

Crystal structure of the kelch domain of human KLHL2 (Mayven)

Canning, P., Hozjan, V., Cooper, C.D.O., Ayinampudi, V., Vollmar, M., Pike, A.C.W., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N.

(2013) J Biological Chem 288: 7803

Released	2010-08-18
Method	X-RAY DIFFRACTION 1.99 Å
Organisms	Homo sapiens
Macromolecule	KELCH-LIKE PROTEIN 2 (protein)
Unique Ligands	EDO, NA, SO4

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2XVT \| pdb_00002xvt	Download File View File

Structure of the extracellular domain of human RAMP2

Quigley, A., Pike, A.C.W., Burgess-Brown, N., Krojer, T., Shrestha, L., Goubin, S., Kim, J., Das, S., Muniz, J.R.C., Canning, P., Chaikuad, A., Vollmar, M., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Bountra, C., Barr, A.J., Carpenter, E.P.

To be published

Released	2010-12-29
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Homo sapiens
Macromolecule	RECEPTOR ACTIVITY-MODIFYING PROTEIN 2 (protein)
Unique Ligands	CA

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2XWC \| pdb_00002xwc	Download File View File

Crystal structure of the DNA binding domain of human TP73 refined at 1.8 A resolution

Canning, P., Zhang, Y., Vollmar, M., Krojer, T., Ugochukwu, E., Muniz, J.R.C., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N.

(2012) J Mol Biology 423: 515

Released	2010-11-17
Method	X-RAY DIFFRACTION 1.82 Å
Organisms	Homo sapiens
Macromolecule	TUMOUR PROTEIN P73 (protein)
Unique Ligands	GOL, TAM, ZN

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2YPS \| pdb_00002yps	Download File View File

Crystal structure of the PX domain of human sorting nexin 3

Canning, P., Kiyani, W., Froese, D.S., Krojer, T., Strain-Damerell, C., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Yue, W.W.

To be published

Released	2013-03-20
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	SORTING NEXIN-3 (protein)

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3MQM \| pdb_00003mqm	Download File View File

Crystal Structure of the Bromodomain of human ASH1L

Filippakopoulos, P., Picaud, S., Keates, T., Felletar, I., Vollmar, M., Chaikuad, A., Krojer, T., Canning, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

(2012) Cell 149: 214-231

Released	2010-05-19
Method	X-RAY DIFFRACTION 2.54 Å
Organisms	Homo sapiens
Macromolecule	Probable histone-lysine N-methyltransferase ASH1L (protein)

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3MTF \| pdb_00003mtf	Download File View File

Crystal structure of the ACVR1 kinase in complex with a 2-aminopyridine inhibitor

Chaikuad, A., Sanvitale, C., Cooper, C., Mahajan, P., Daga, N., Petrie, K., Alfano, I., Canning, P., Krojer, T., Vollmar, M., Knapp, S., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)

(2013) PLoS One 8: e62721-e62721

Released	2010-06-23
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	Activin receptor type-1 (protein)
Unique Ligands	A3F, EDO, PO4

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3OP0 \| pdb_00003op0	Download File View File

Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide

Chaikuad, A., Guo, K., Cooper, C.D.O., Ayinampudi, V., Krojer, T., Ugochukwu, E., Muniz, J.R.C., Vollmar, M., Canning, P., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)

To be published

Released	2010-10-20
Method	X-RAY DIFFRACTION 2.52 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein) Signal transduction protein CBL-C (protein)
Unique Ligands	NA, NI

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3PFV \| pdb_00003pfv	Download File View File

Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide

Chaikuad, A., Guo, K., Cooper, C.D.O., Ayinampudi, V., Krojer, T., Muniz, J.R.C., Vollmar, M., Canning, P., Gileadi, O., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)

To be published

Released	2010-12-08
Method	X-RAY DIFFRACTION 2.27 Å
Organisms	Homo sapiens
Macromolecule	11-meric peptide from Epidermal growth factor receptor (protein) E3 ubiquitin-protein ligase CBL-B (protein)
Unique Ligands	CL, EDO, NA, PG4, SO4

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3T7L \| pdb_00003t7l	Download File View File

Crystal structure of the FYVE domain of endofin (ZFYVE16) at 1.1A resolution

Chaikuad, A., Williams, E., Guo, K., Sanvitale, C., Berridge, G., Krojer, T., Muniz, J.R.C., Canning, P., Phillips, C., Shrestha, A., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)

To be published

Released	2011-08-31
Method	X-RAY DIFFRACTION 1.09 Å
Organisms	Homo sapiens
Macromolecule	Zinc finger FYVE domain-containing protein 16 (protein)
Unique Ligands	EDO, ZN

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3ZDU \| pdb_00003zdu	Download File View File

Crystal structure of the human CDKL3 kinase domain

Canning, P., Elkins, J.M., Goubin, S., Mahajan, P., Pike, A.C.W., Quigley, A., MacKenzie, A., Carpenter, E.P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.

(2018) Cell Rep 22: 885-894

Released	2013-03-20
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	CYCLIN-DEPENDENT KINASE-LIKE 3 (protein)
Unique Ligands	38R, EDO, NA, ZN

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3ZOS \| pdb_00003zos	Download File View File

Structure of the DDR1 kinase domain in complex with ponatinib

Canning, P., Elkins, J.M., Goubin, S., Mahajan, P., Bradley, A., Coutandin, D., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.

(2014) J Mol Biology 426: 2457

Released	2013-05-01
Method	X-RAY DIFFRACTION 1.92 Å
Organisms	Homo sapiens
Macromolecule	EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 (protein)
Unique Ligands	0LI, EDO

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4A35 \| pdb_00004a35	Download File View File

Crystal structure of human Mitochondrial enolase superfamily member 1 (ENOSF1)

Muniz, J.R.C., Froese, D.S., Krojer, T., Vollmar, M., Canning, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Oppermann, U., Yue, W.W.

(2014) Biochemistry 53: 2732-2738

Released	2011-10-12
Method	X-RAY DIFFRACTION 1.74 Å
Organisms	Homo sapiens
Macromolecule	MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1 (protein)
Unique Ligands	EDO, MG

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4A63 \| pdb_00004a63	Download File View File

Crystal structure of the p73-ASPP2 complex at 2.6A resolution

Canning, P., Sharpe, T., Krojer, T., Savitsky, P., Cooper, C.D.O., Salah, E., Keates, T., Muniz, J., Vollmar, M., von Delft, F., Weigelt, J., Arrowsmith, C., Bountra, C., Edwards, A., Bullock, A.N.

(2012) J Mol Biology 423: 515

Released	2011-12-21
Method	X-RAY DIFFRACTION 2.27 Å
Organisms	Homo sapiens
Macromolecule	APOPTOSIS STIMULATING OF P53 PROTEIN 2 (protein) TUMOUR PROTEIN 73 (protein)
Unique Ligands	ACT, ZN

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4AAA \| pdb_00004aaa	Download File View File

Crystal structure of the human CDKL2 kinase domain

Canning, P., Vollmar, M., Cooper, C.D.O., Mahajan, P., Daga, N., Berridge, G., Burgess-Brown, N., Muniz, J.R.C., Krojer, T., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.

(2018) Cell Rep 22: 885-894

Released	2011-12-21
Method	X-RAY DIFFRACTION 1.53 Å
Organisms	Homo sapiens
Macromolecule	CYCLIN-DEPENDENT KINASE-LIKE 2 (protein)
Unique Ligands	DKI, EDO

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4AAP \| pdb_00004aap	Download File View File

Crystal structure of JMJD5 domain of human Lysine-specific demethylase 8 (KDM8) in complex with N-oxalylglycine (NOG)

Vollmar, M., Johansson, C., Krojer, T., Canning, P., Allerston, C., Gadhave, A., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Oppermann, U.

To be published

Released	2012-02-29
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	LYSINE-SPECIFIC DEMETHYLASE 8 (protein)
Unique Ligands	OGA, ZN

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4AGU \| pdb_00004agu	Download File View File

CRYSTAL STRUCTURE OF THE HUMAN CDKL1 KINASE DOMAIN

Canning, P., Sharpe, T.D., Allerston, C., Savitsky, P., Pike, A.C.W., Muniz, J.R.C., Chaikuad, A., Kuo, K., Burgess-Brown, N., Ayinampudi, V., Zhang, Y., Thangaratnarajah, C., Ugochukwu, E., Vollmar, M., Krojer, T., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Knapp, S., Bullock, A.

(2018) Cell Rep 22: 885-894

Released	2012-02-08
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	CYCLIN-DEPENDENT KINASE-LIKE 1 (protein)
Unique Ligands	D15

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4AMY \| pdb_00004amy	Download File View File

PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND INHIBITOR IC-1

Kaszuba, K., Rog, T., Danne, R., Canning, P., Fulop, V., Juhasz, T., Szeltner, Z., St-Pierre, J.F., Garcia-Horsman, A., Mannisto, P.T., Karttunen, M., Hokkanen, J., Bunker, A.

(2012) Biochimie 94: 1398

Released	2012-05-16
Method	X-RAY DIFFRACTION 2 Å
Organisms	Sus scrofa
Macromolecule	PROLYL ENDOPEPTIDASE (protein)
Unique Ligands	2P2, GOL

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4AMZ \| pdb_00004amz	Download File View File

PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND INHIBITOR IC-2

Kaszuba, K., Rog, T., Danne, R., Canning, P., Fulop, V., Juhasz, T., Szeltner, Z., St-Pierre, J.F., Garcia-Horsman, A., Mannisto, P.T., Karttunen, M., Hokkanen, J., Bunker, A.

(2012) Biochimie 94: 1398

Released	2012-05-16
Method	X-RAY DIFFRACTION 2 Å
Organisms	Sus scrofa
Macromolecule	PROLYL ENDOPEPTIDASE (protein)
Unique Ligands	2P4, GOL

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4AN0 \| pdb_00004an0	Download File View File

PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND INHIBITOR IC-3

Kaszuba, K., Rog, T., Danne, R., Canning, P., Fulop, V., Juhasz, T., Szeltner, Z., St-Pierre, J.F., Garcia-Horsman, A., Mannisto, P.T., Karttunen, M., Hokkanen, J., Bunker, A.

(2012) Biochimie 94: 1398-1411

Released	2012-05-16
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Sus scrofa
Macromolecule	PROLYL ENDOPEPTIDASE (protein)
Unique Ligands	2P6, GOL

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4AN1 \| pdb_00004an1	Download File View File

PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND INHIBITOR IC-4

Kaszuba, K., Rog, T., Danne, R., Canning, P., Fulop, V., Juhasz, T., Szeltner, Z., St-Pierre, J.F., Garcia-Horsman, A., Mannisto, P.T., Karttunen, M., Hokkanen, J., Bunker, A.

(2012) Biochimie 94: 1398

Released	2012-05-16
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Sus scrofa
Macromolecule	PROLYL ENDOPEPTIDASE (protein)
Unique Ligands	2P8, GOL

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4AOT \| pdb_00004aot	Download File View File

Crystal Structure of Human Serine Threonine Kinase-10 (LOK) Bound to GW830263A

Elkins, J.M., Salah, E., Szklarz, M., Canning, P., von Delft, F., Yue, W., Liu, Y., Bountra, C., Arrowsmith, C., Edwards, A., Knapp, S.

To be published

Released	2012-04-11
Method	X-RAY DIFFRACTION 2.33 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase 10 (protein)
Unique Ligands	CL, GW8

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4AP2 \| pdb_00004ap2	Download File View File

Crystal structure of the human KLHL11-Cul3 complex at 2.8A resolution

Canning, P., Cooper, C.D.O., Krojer, T., Filippakopoulos, P., Ayinampudi, V., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Bullock, A.N., Structural Genomics Consortium (SGC)

(2013) J Biological Chem 288: 7803

Released	2012-05-09
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	CULLIN-3 (protein) KELCH-LIKE PROTEIN 11 (protein)
Unique Ligands	CL, EDO, IOD

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4APF \| pdb_00004apf	Download File View File

Crystal structure of the human KLHL11-Cul3 complex at 3.1A resolution

Canning, P., Cooper, C.D.O., Krojer, T., Vollmar, M., Ugochukwu, E., Muniz, J.R.C., Ayinampudi, V., Savitsky, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Bullock, A.N., Structural Genomics Consortium (SGC)

(2013) J Biological Chem 288: 7803

Released	2012-05-09
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens
Macromolecule	CULLIN 3 (protein) KELCH-LIKE PROTEIN 11 (protein)

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4ASC \| pdb_00004asc	Download File View File

Crystal structure of the Kelch domain of human KBTBD5

Canning, P., Ayinampudi, V., Krojer, T., Strain-Damerell, C., Raynor, J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N., Structural Genomics Consortium (SGC)

(2013) J Biological Chem 288: 7803

Released	2012-05-09
Method	X-RAY DIFFRACTION 1.78 Å
Organisms	Homo sapiens
Macromolecule	KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 5 (protein)
Unique Ligands	EDO

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4ASX \| pdb_00004asx	Download File View File

Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dihydro-Bauerine C

Williams, E., Chaikuad, A., Canning, P., Kochan, G., Mahajan, P., Cooper, C.D.O., Beltrami, A., Krojer, T., Pohl, B., Bracher, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Bullock, A.

To be published

Released	2012-05-23
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Homo sapiens
Macromolecule	ACTIVIN RECEPTOR TYPE-2A (protein)
Unique Ligands	6OJ, EDO

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

2XN4 | pdb_00002xn4

2XVT | pdb_00002xvt

2XWC | pdb_00002xwc

2YPS | pdb_00002yps

3MQM | pdb_00003mqm

3MTF | pdb_00003mtf

3OP0 | pdb_00003op0

3PFV | pdb_00003pfv

3T7L | pdb_00003t7l

3ZDU | pdb_00003zdu

3ZOS | pdb_00003zos

4A35 | pdb_00004a35

4A63 | pdb_00004a63

4AAA | pdb_00004aaa

4AAP | pdb_00004aap

4AGU | pdb_00004agu

4AMY | pdb_00004amy

4AMZ | pdb_00004amz

4AN0 | pdb_00004an0

4AN1 | pdb_00004an1

4AOT | pdb_00004aot

4AP2 | pdb_00004ap2

4APF | pdb_00004apf

4ASC | pdb_00004asc

4ASX | pdb_00004asx