RCSB PDB: Search

5AME \| pdb_00005ame	Download File View File

Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D Consortium fragment 4-acetyl- piperazin-2-one (SGC - Diamond I04-1 fragment screening)

Pearce, N.M., Fairhead, M., Strain-Damerell, C., Talon, R., Wright, N., Ng, J.T., Bradley, A., Cox, O., Bowkett, D., Collins, P., Brandao-Neto, J., Douangamath, A., Krojer, T., Burgess-Brown, N., Brennan, P., Arrowsmith, C.H., Edwards, E., Bountra, C., von Delft, F.

To be published

Released	2015-03-18
Method	X-RAY DIFFRACTION 1.578 Å
Organisms	Homo sapiens
Macromolecule	BROMODOMAIN-CONTAINING PROTEIN 1 (protein)
Unique Ligands	NA, PW3

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5AMF \| pdb_00005amf	Download File View File

Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D Consortium fragment Ethyl 4,5,6,7- tetrahydro-1H-indazole-5-carboxylate (SGC - Diamond I04-1 fragment screening)

Pearce, N.M., Fairhead, M., Strain-Damerell, C., Talon, R., Wright, N., Ng, J.T., Bradley, A., Cox, O., Bowkett, D., Collins, P., Brandao-Neto, J., Douangamath, A., Krojer, T., Burgess-Brown, N., Brennan, P., Arrowsmith, C.H., Edwards, E., Bountra, C., von Delft, F.

To be published

Released	2015-03-18
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	BROMODOMAIN-CONTAINING PROTEIN 1 (protein)
Unique Ligands	NA, TWL

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5PB7 \| pdb_00005pb7	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B in complex with N09440a

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-15
Method	X-RAY DIFFRACTION 1.655 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	8H4, EDO

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5PB8 \| pdb_00005pb8	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B in complex with N09522a

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-15
Method	X-RAY DIFFRACTION 1.649 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	AC6, EDO

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5PB9 \| pdb_00005pb9	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B in complex with N09521a

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-15
Method	X-RAY DIFFRACTION 1.782 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	53C, EDO

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5PBA \| pdb_00005pba	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B in complex with N09460a

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-15
Method	X-RAY DIFFRACTION 1.925 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	53B, EDO, MES

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5PBB \| pdb_00005pbb	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B in complex with N09496a

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-15
Method	X-RAY DIFFRACTION 1.783 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	EDO, ES1

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5PBC \| pdb_00005pbc	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B in complex with N09724a

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-15
Method	X-RAY DIFFRACTION 1.771 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	EDO, ES3

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5PBD \| pdb_00005pbd	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B in complex with N09682a

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-15
Method	X-RAY DIFFRACTION 1.776 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	EDO, TYZ

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5PBE \| pdb_00005pbe	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B in complex with N09428a

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-15
Method	X-RAY DIFFRACTION 1.835 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	EDO, TYL

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5PBF \| pdb_00005pbf	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B in complex with N09645a

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-15
Method	X-RAY DIFFRACTION 1.801 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	8HJ, EDO

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5PBG \| pdb_00005pbg	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B after initial refinement with no ligand modelled (structure 1)

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-22
Method	X-RAY DIFFRACTION 1.72 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	EDO

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5PBH \| pdb_00005pbh	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B after initial refinement with no ligand modelled (structure 2)

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-22
Method	X-RAY DIFFRACTION 1.69 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	EDO

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5PBI \| pdb_00005pbi	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B after initial refinement with no ligand modelled (structure 3)

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-22
Method	X-RAY DIFFRACTION 1.78 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	EDO

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5PBJ \| pdb_00005pbj	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B after initial refinement with no ligand modelled (structure 4)

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-22
Method	X-RAY DIFFRACTION 1.79 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	EDO

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5PBK \| pdb_00005pbk	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B after initial refinement with no ligand modelled (structure 5)

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-22
Method	X-RAY DIFFRACTION 1.77 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	EDO

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5PBL \| pdb_00005pbl	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B after initial refinement with no ligand modelled (structure 6)

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-22
Method	X-RAY DIFFRACTION 1.84 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	EDO

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5PBM \| pdb_00005pbm	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B after initial refinement with no ligand modelled (structure 7)

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-22
Method	X-RAY DIFFRACTION 1.67 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	EDO

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5PBN \| pdb_00005pbn	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B after initial refinement with no ligand modelled (structure 8)

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-22
Method	X-RAY DIFFRACTION 1.86 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	EDO

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5PBO \| pdb_00005pbo	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B after initial refinement with no ligand modelled (structure 9)

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-22
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	EDO

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5PBP \| pdb_00005pbp	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B after initial refinement with no ligand modelled (structure 10)

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-22
Method	X-RAY DIFFRACTION 1.88 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	EDO

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5PBQ \| pdb_00005pbq	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B after initial refinement with no ligand modelled (structure 11)

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-22
Method	X-RAY DIFFRACTION 1.93 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	EDO

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5PBR \| pdb_00005pbr	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B after initial refinement with no ligand modelled (structure 12)

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-22
Method	X-RAY DIFFRACTION 1.81 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	EDO

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5PBS \| pdb_00005pbs	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B after initial refinement with no ligand modelled (structure 13)

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-22
Method	X-RAY DIFFRACTION 1.77 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	EDO

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5PBT \| pdb_00005pbt	Download File View File

PanDDA analysis group deposition -- Crystal Structure of BAZ2B after initial refinement with no ligand modelled (structure 14)

Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Vollmar, M., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

(2017) Nat Commun 8: 15123-15123

Released	2017-03-22
Method	X-RAY DIFFRACTION 1.79 Å
Organisms	Homo sapiens
Macromolecule	Bromodomain adjacent to zinc finger domain protein 2B (protein)
Unique Ligands	EDO

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

5AME | pdb_00005ame

5AMF | pdb_00005amf

5PB7 | pdb_00005pb7

5PB8 | pdb_00005pb8

5PB9 | pdb_00005pb9

5PBA | pdb_00005pba

5PBB | pdb_00005pbb

5PBC | pdb_00005pbc

5PBD | pdb_00005pbd

5PBE | pdb_00005pbe

5PBF | pdb_00005pbf

5PBG | pdb_00005pbg

5PBH | pdb_00005pbh

5PBI | pdb_00005pbi

5PBJ | pdb_00005pbj

5PBK | pdb_00005pbk

5PBL | pdb_00005pbl

5PBM | pdb_00005pbm

5PBN | pdb_00005pbn

5PBO | pdb_00005pbo

5PBP | pdb_00005pbp

5PBQ | pdb_00005pbq

5PBR | pdb_00005pbr

5PBS | pdb_00005pbs

5PBT | pdb_00005pbt