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December 1: World AIDS Day

11/27 PDB101 News

HIV (human immunodeficiency virus) is composed of two strands of RNA, 15 types of viral proteins, and a few proteins from the last host cell it infected, all surrounded by a lipid bilayer membrane. Together, these molecules allow the virus to infect cells of the immune system and force them to build new copies of the virus. Each molecule in the virus plays a role in this process, from the first steps of viral attachment to the final process of budding.

Since 1986, research on the structural biology of HIV has revealed the atomic details of these proteins. These structures are all publicly available in the PDB archive. Using these data, researchers have designed new treatments for HIV infection, including effective drug regimens that halt the growth of the virus. The structures also provide new hope for development of a vaccine.

PDB-101 hosts a variety of related materials, including Molecule of the Month features, videos, posters, and more.

Target Zero<I> is a documentary that shows the challenge and emotional complexity of the fight to control HIV infection. It features real-life patient stories, state of the art molecular animations based on PDB data, and interviews with medical professionals and scientists. These accounts illuminate the history of the HIV epidemic and reveal the ongoing need for compassionate, patient-centered care and a true understanding of the science behind the treatments. </I>Target Zero is a documentary that shows the challenge and emotional complexity of the fight to control HIV infection. It features real-life patient stories, state of the art molecular animations based on PDB data, and interviews with medical professionals and scientists. These accounts illuminate the history of the HIV epidemic and reveal the ongoing need for compassionate, patient-centered care and a true understanding of the science behind the treatments.

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