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Nitric oxide synthase, inducible

UniProtKB accession:  P29477
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Polymer Entities matching query 53
Go to UniProtKB:  P29477
UniProtKB description:  Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7503239). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (PubMed:16373578). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (By similarity). Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8 (By similarity).
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Sequence Features
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Experimental Features
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Resolution


Organisms
Organism
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Protein Domains
SCOP/SCOPe Domain
CATH Domain
ECOD Domain
PFAM Domain
InterPro Domain
[ 7+ ]


Function
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GO Molecular Function
GO Biological Process
[ 14+ ]
GO Cellular Component
Phenotype Association