Annotations: 9DW5

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Cystic fibrosis transmembrane conductance regulator	monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity intracellularly ligand-gated monoatomic ion channel activity gated channel activity monoatomic ion channel activity intracellularly ATP-gated chloride channel activity intracellularly ATP-gated ion channel activity ligand-gated monoatomic anion channel activity ATP-gated ion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity intracellularly ligand-gated monoatomic ion channel activity gated channel activity monoatomic ion channel activity intracellularly ATP-gated chloride channel activity intracellularly ATP-gated ion channel activity ligand-gated monoatomic anion channel activity ATP-gated ion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity monoatomic anion channel activity transporter activity transmembrane transporter activity inorganic anion transmembrane transporter activity chloride channel activity ABC-type transporter activity active transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity ATP-dependent activity bicarbonate transmembrane transporter activity organic anion transmembrane transporter activity molecular function inhibitor activity chloride channel inhibitor activity channel regulator activity transporter inhibitor activity ion channel regulator activity ion channel inhibitor activity molecular function regulator activity transporter regulator activity channel inhibitor activity chloride channel regulator activity protein binding binding protein-folding chaperone binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding Sec61 translocon complex binding protein-containing complex binding PDZ domain binding protein domain specific binding ATPase-coupled inorganic anion transmembrane transporter activity isomerase activity catalytic activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides enzyme binding	developmental process spermatid development spermatid differentiation sexual reproduction cellular developmental process spermatogenesis reproductive process multicellular organismal reproductive process cell development cellular process involved in reproduction in multicellular organism developmental maturation developmental process involved in reproduction gamete generation male gamete generation sperm capacitation developmental process spermatid development spermatid differentiation sexual reproduction cellular developmental process spermatogenesis reproductive process multicellular organismal reproductive process cell development cellular process involved in reproduction in multicellular organism developmental maturation developmental process involved in reproduction gamete generation male gamete generation sperm capacitation anatomical structure maturation cell differentiation anatomical structure development germ cell development cellular process cell maturation transport monoatomic ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport establishment of localization chloride transport transmembrane transport localization chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport monoatomic ion transport inorganic anion transport macromolecule localization lipid localization cholesterol transport lipid transport sterol transport organic hydroxy compound transport bicarbonate transport organic anion transport regulation of localization regulation of cellular process positive regulation of biological process regulation of voltage-gated chloride channel activity regulation of transmembrane transporter activity regulation of monoatomic ion transmembrane transport regulation of transporter activity positive regulation of molecular function regulation of monoatomic anion transport positive regulation of monoatomic ion transport positive regulation of transmembrane transport positive regulation of monoatomic ion transmembrane transport positive regulation of cellular process regulation of chloride transport regulation of monoatomic ion transmembrane transporter activity regulation of biological process positive regulation of voltage-gated chloride channel activity regulation of transport positive regulation of anion channel activity regulation of monoatomic ion transport biological regulation regulation of monoatomic anion transmembrane transport regulation of anion channel activity positive regulation of anion transmembrane transport positive regulation of monoatomic anion transport regulation of molecular function regulation of transmembrane transport positive regulation of transport positive regulation of transporter activity positive regulation of ion transmembrane transporter activity positive regulation of inorganic anion transmembrane transport regulation of inorganic anion transmembrane transport transepithelial water transport epithelial fluid transport transepithelial transport fluid transport water transport anatomical structure morphogenesis odontogenesis of dentin-containing tooth anatomical structure formation involved in morphogenesis odontogenesis animal organ development amelogenesis animal organ morphogenesis regulation of biological quality membrane hyperpolarization regulation of membrane potential cellular response to stimulus cellular response to stress response to stimulus response to stress response to endoplasmic reticulum stress positive regulation of cyclic nucleotide-gated ion channel activity regulation of cyclic nucleotide-gated ion channel activity positive regulation of secretion by cell positive regulation of exocytosis vesicle-mediated transport regulation of secretion by cell secretion by cell positive regulation of secretion secretion export from cell regulation of vesicle-mediated transport regulation of secretion exocytosis regulation of exocytosis membrane docking organelle localization by membrane tethering organelle localization vesicle docking exocytic process vesicle docking involved in exocytosis regulation of body fluid levels multicellular organismal process multicellular organismal-level homeostasis chemical homeostasis homeostatic process multicellular organismal-level water homeostasis multicellular organismal-level chemical homeostasis enamel mineralization tooth mineralization regulation of developmental process regulation of biomineral tissue development positive regulation of enamel mineralization positive regulation of developmental process multicellular organism development positive regulation of biomineral tissue development biomineral tissue development regulation of multicellular organismal process regulation of multicellular organismal development tissue development regulation of tooth mineralization regulation of enamel mineralization positive regulation of tooth mineralization cellular response to nitrogen compound response to organophosphorus cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound response to purine-containing compound response to cAMP cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical cellular response to cAMP response to organic cyclic compound secondary alcohol biosynthetic process small molecule biosynthetic process cholesterol biosynthetic process organic hydroxy compound metabolic process sterol metabolic process steroid metabolic process cholesterol metabolic process lipid biosynthetic process alcohol metabolic process primary metabolic process secondary alcohol metabolic process biosynthetic process sterol biosynthetic process organic hydroxy compound biosynthetic process alcohol biosynthetic process small molecule metabolic process metabolic process steroid biosynthetic process lipid metabolic process cellular localization establishment of localization in cell protein localization positive regulation of cell communication establishment of protein localization nitrogen compound transport positive regulation of establishment of protein localization cell communication carbohydrate homeostasis cellular macromolecule localization positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of insulin secretion regulation of peptide hormone secretion regulation of hormone levels positive regulation of peptide hormone secretion establishment of protein localization to extracellular region intracellular glucose homeostasis protein secretion regulation of protein secretion cellular response to carbohydrate stimulus response to glucose glucose homeostasis positive regulation of protein localization insulin secretion involved in cellular response to glucose stimulus regulation of hormone secretion regulation of protein localization regulation of peptide secretion signaling hormone secretion protein localization to extracellular region positive regulation of protein transport peptide secretion positive regulation of hormone secretion response to monosaccharide response to carbohydrate amide transport signal release cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus positive regulation of peptide secretion regulation of signaling regulation of peptide transport regulation of establishment of protein localization cell-cell signaling cellular response to glucose stimulus regulation of protein transport positive regulation of protein secretion peptide transport response to hexose cellular homeostasis protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion regulation of insulin secretion involved in cellular response to glucose stimulus hormone transport regulation of cell communication insulin secretion positive regulation of signaling regulation of intracellular pH intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis monoatomic cation homeostasis intracellular pH elevation regulation of cellular pH intracellular monoatomic ion homeostasis response to ketone response to lipid response to alcohol cellular response to forskolin cellular response to alcohol response to forskolin cellular response to lipid cellular response to ketone	protein-containing complex cellular anatomical structure transmembrane transporter complex membrane chloride channel complex membrane protein complex transporter complex monoatomic ion channel complex membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle bounding membrane of organelle cytoplasmic vesicle protein-containing complex cellular anatomical structure transmembrane transporter complex membrane chloride channel complex membrane protein complex transporter complex monoatomic ion channel complex membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane intracellular membrane-bounded organelle clathrin-coated endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane organelle cytoplasm organelle membrane cytosol vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome endosome recycling endosome endomembrane system endosome membrane Golgi-associated vesicle membrane Golgi-associated vesicle cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane cell surface organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane early endosome recycling endosome membrane early endosome membrane nucleus
B [auth G]	cAMP-dependent protein kinase catalytic subunit alpha	protein binding binding protein domain specific binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity AMP-activated protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups cyclic nucleotide-dependent protein kinase activity cAMP-dependent protein kinase activity protein binding binding protein domain specific binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity AMP-activated protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups cyclic nucleotide-dependent protein kinase activity cAMP-dependent protein kinase activity protein serine kinase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein kinase A binding protein kinase A regulatory subunit binding	cellular response to stimulus cellular response to heat response to stimulus cellular response to stress response to stress response to heat response to abiotic stimulus cellular process response to temperature stimulus regulation of biological process regulation of cellular process signaling biological regulation intracellular signal transduction cellular response to stimulus cellular response to heat response to stimulus cellular response to stress response to stress response to heat response to abiotic stimulus cellular process response to temperature stimulus regulation of biological process regulation of cellular process signaling biological regulation intracellular signal transduction cell communication protein kinase A signaling signal transduction protein phosphorylation phosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction negative regulation of cell communication negative regulation of TORC1 signaling regulation of intracellular signal transduction negative regulation of TOR signaling negative regulation of cellular process regulation of TORC1 signaling TOR signaling regulation of signaling regulation of TOR signaling negative regulation of response to stimulus negative regulation of signal transduction regulation of response to stimulus regulation of cell communication TORC1 signaling peptidyl-serine modification peptidyl-serine phosphorylation peptidyl-amino acid modification developmental process multicellular organismal process formation of primary germ layer mesoderm morphogenesis embryonic morphogenesis tissue development embryo development gastrulation tissue morphogenesis anatomical structure morphogenesis multicellular organism development anatomical structure development anatomical structure formation involved in morphogenesis mesoderm formation mesoderm development	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cytosol cell projection cilium 9+2 motile cilium sperm flagellum motile cilium membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cytosol cell projection cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection cell periphery plasma membrane membrane neuromuscular junction synapse cell junction perinuclear region of cytoplasm protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex cAMP-dependent protein kinase complex serine/threonine protein kinase complex transferase complex intracellular protein-containing complex nucleus acrosomal vesicle intracellular vesicle endomembrane system cytoplasmic vesicle secretory granule secretory vesicle vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR047082	Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette domain 1	Domain
A	IPR003439	ABC transporter-like, ATP-binding domain	Domain
A	IPR009147	Cystic fibrosis transmembrane conductance regulator	Family
A	IPR025837	CFTR regulator domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR003593	AAA+ ATPase domain	Domain
A	IPR011527	ABC transporter type 1, transmembrane domain	Domain
A	IPR017871	ABC transporter-like, conserved site	Conserved Site
A	IPR036640	ABC transporter type 1, transmembrane domain superfamily	Homologous Superfamily
A	IPR050173	ATP-binding cassette transporter C-like	Family
B [auth G]	IPR017441	Protein kinase, ATP binding site	Binding Site
B [auth G]	IPR000719	Protein kinase domain	Domain
B [auth G]	IPR000961	AGC-kinase, C-terminal	Domain
B [auth G]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B [auth G]	IPR044109	cAMP-dependent protein kinase catalytic subunit	Family
B [auth G]	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P13569	cystic fibrosis pancreatitis rhinitis bronchiectasis with or without elevated sweat chloride 1 autosomal recessive polycystic kidney disease Congenital bilateral aplasia of vas deferens sinusitis esophageal adenocarcinoma azoospermia male infertility chronic pancreatitis congenital bilateral aplasia of vas deferens from CFTR mutation hereditary chronic pancreatitis choledochal cyst colorectal cancer cystic fibrosis pancreatitis rhinitis bronchiectasis with or without elevated sweat chloride 1 autosomal recessive polycystic kidney disease Congenital bilateral aplasia of vas deferens sinusitis esophageal adenocarcinoma azoospermia male infertility chronic pancreatitis congenital bilateral aplasia of vas deferens from CFTR mutation hereditary chronic pancreatitis choledochal cyst colorectal cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia congenital diaphragmatic hernia drug dependence endogenous depression substance dependence heart disease bronchiectasis lung adenocarcinoma lung disease colorectal carcinoma pancreatic intraductal papillary-mucinous carcinoma cutaneous lupus erythematosus psoriasis substance abuse attention deficit hyperactivity disorder, inattentive type hemochromatosis type 1 idiopathic bronchiectasis Tourette syndrome lung cancer malignant mesothelioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm plantar fibromatosis Sjogren syndrome substance-related disorder Barrett esophagus inflammatory bowel disease ulcerative colitis lung carcinoma male infertility with azoospermia or oligozoospermia due to single gene mutation cholestasis malignant pancreatic neoplasm

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B [auth G]	PDBTM	Annotated as membrane protein by PDBTM

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B [auth G]	TPO	Parent Component: THR RESID: AA0038 PSI-MOD : O-phospho-L-threonine MOD:00047

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.