9FLF

Three-Dimensional Structure of Human Carbonic Anhydrase IX in Complex with a Covalent Inhibitor

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Carbonic anhydrase	molecular function activator activity molecular function regulator activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding carbonate dehydratase activity hydro-lyase activity lyase activity catalytic activity carbon-oxygen lyase activity	response to stimulus response to chemical response to xenobiotic stimulus localization secretion transport establishment of localization small molecule metabolic process metabolic process cellular process one-carbon metabolic process developmental process tissue morphogenesis anatomical structure morphogenesis response to stimulus response to chemical response to xenobiotic stimulus localization secretion transport establishment of localization small molecule metabolic process metabolic process cellular process one-carbon metabolic process developmental process tissue morphogenesis anatomical structure morphogenesis epithelium development anatomical structure development morphogenesis of an epithelium tissue development response to decreased oxygen levels response to hypoxia response to stress response to oxygen levels response to abiotic stimulus response to ketone response to lipid response to oxygen-containing compound response to testosterone response to organic cyclic compound	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane plasma membrane plasma membrane bounded cell projection cell periphery cell projection actin-based cell projection plasma membrane region microvillus microvillus membrane cell projection membrane basal part of cell basal plasma membrane basolateral plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR018338	Carbonic anhydrase, alpha-class, conserved site	Conserved Site
A, B, C, D	IPR001148	Alpha carbonic anhydrase domain	Domain
A, B, C, D	IPR036398	Alpha carbonic anhydrase domain superfamily	Homologous Superfamily
A, B, C, D	IPR023561	Carbonic anhydrase, alpha-class	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q16790	chronic myelogenous leukemia, BCR-ABL1 positive Anaplasia pulmonary hypertension psoriasis malignant colon neoplasm malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous neoplasm breast ductal adenocarcinoma ductal breast carcinoma in situ malignant ependymoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis cancer kidney disease chronic myelogenous leukemia, BCR-ABL1 positive Anaplasia pulmonary hypertension psoriasis malignant colon neoplasm malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous neoplasm breast ductal adenocarcinoma ductal breast carcinoma in situ malignant ependymoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis cancer kidney disease malignant mesothelioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.