8JN8 | pdb_00008jn8

Crystal structure of c-Src in complex with covalent inhibitor DC-Srci-6668

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SH3-domain	8033421	3000153	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	SH2 domain	8037200	3000197	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Protein kinase-like (PK-like)	8033424	3000066	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00017	SH2 domain (SH2)	SH2 domain		Domain
A	PF00018	SH3 domain (SH3_1)	SH3 domain	SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.	Domain
A	PF07714	Protein tyrosine and serine/threonine kinase (PK_Tyr_Ser-Thr)	Protein tyrosine and serine/threonine kinase	Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphospha ...	Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity [1]; Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins). This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include the catalytic domain of dual specificity kinases.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Proto-oncogene tyrosine-protein kinase Src	protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding non-membrane spanning protein tyrosine kinase activity cell adhesion molecule binding cadherin binding protein binding signaling receptor binding ephrin receptor binding scaffold protein binding BMP receptor binding receptor serine/threonine kinase binding transmembrane receptor protein serine/threonine kinase binding tetrapyrrole binding heme binding connexin binding histone H2AXY142 kinase activity histone modifying activity histone kinase activity histone H2AX kinase activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding nuclear estrogen receptor binding protein tyrosine kinase activator activity enzyme regulator activity molecular function activator activity protein kinase regulator activity kinase activator activity enzyme activator activity molecular function regulator activity protein kinase activator activity kinase regulator activity phosphoprotein binding histone H3Y41 kinase activity histone H3 kinase activity insulin receptor binding ATPase binding enzyme binding phospholipase binding SH2 domain binding protein domain specific binding transmembrane transporter binding protein-containing complex binding integrin binding hydrolase activity phospholipase activity lipase activity hydrolase activity, acting on ester bonds phospholipase activator activity lipase activator activity kinase binding protein kinase C binding protein kinase binding	response to stimulus response to chemical response to xenobiotic stimulus myoblast proliferation cell population proliferation cellular process cellular response to stimulus cellular response to nitrogen compound response to endogenous stimulus response to peptide hormone cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound response to stimulus response to chemical response to xenobiotic stimulus myoblast proliferation cell population proliferation cellular process cellular response to stimulus cellular response to nitrogen compound response to endogenous stimulus response to peptide hormone cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone cellular response to hormone stimulus regulation of biological process regulation of cellular process regulation of mitochondrial depolarization negative regulation of membrane depolarization biological regulation negative regulation of biological process mitochondrial depolarization regulation of membrane depolarization regulation of mitochondrial membrane potential membrane depolarization regulation of biological quality negative regulation of mitochondrial depolarization regulation of membrane potential biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction cell adhesion substrate adhesion-dependent cell spreading cell-substrate adhesion negative regulation of programmed cell death regulation of apoptotic process regulation of anoikis regulation of programmed cell death cell death negative regulation of anoikis negative regulation of apoptotic process anoikis negative regulation of cellular process apoptotic process programmed cell death cell-cell adhesion regulation of cell adhesion regulation of cell-cell adhesion positive regulation of locomotion regulation of cell motility positive regulation of smooth muscle cell migration regulation of smooth muscle cell migration positive regulation of biological process positive regulation of cell migration smooth muscle cell migration muscle cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion positive regulation of cellular process cell surface receptor signaling pathway signaling platelet-derived growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell communication signal transduction enzyme-linked receptor protein signaling pathway multicellular organismal process regulation of body fluid levels wound healing cell activation hemostasis blood coagulation response to stress coagulation response to wounding platelet activation primary metabolic process DNA metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process biosynthetic process metabolic process macromolecule metabolic process DNA biosynthetic process regulation of cellular component organization cell projection organization regulation of cell projection assembly regulation of cell projection organization regulation of cellular component biogenesis cellular component biogenesis cellular component organization cellular component assembly cellular component organization or biogenesis cell projection assembly cellular response to stress response to fluid shear stress cellular response to fluid shear stress negative regulation of telomere maintenance regulation of telomere maintenance telomere organization regulation of primary metabolic process negative regulation of chromosome organization negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of cellular component organization negative regulation of metabolic process chromosome organization regulation of chromosome organization regulation of macromolecule metabolic process regulation of organelle organization telomere maintenance organelle organization negative regulation of organelle organization negative regulation of DNA metabolic process regulation of metabolic process regulation of DNA metabolic process developmental process anatomical structure morphogenesis odontogenesis anatomical structure development animal organ development animal organ morphogenesis epithelium development digestive system development cellular developmental process intestinal epithelial cell differentiation tube development intestinal epithelial cell development cell development tissue development digestive tract development epithelial cell differentiation multicellular organism development epithelial cell development columnar/cuboidal epithelial cell development cell differentiation columnar/cuboidal epithelial cell differentiation system development regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response inflammatory response to antigenic stimulus regulation of response to stress regulation of immune system process negative regulation of inflammatory response to antigenic stimulus defense response immune response negative regulation of response to stimulus negative regulation of immune response regulation of inflammatory response to antigenic stimulus response to external stimulus regulation of inflammatory response regulation of response to stimulus negative regulation of immune system process immune system process negative regulation of response to external stimulus negative regulation of defense response regulation of immune response inflammatory response regulation of protein modification process positive regulation of phosphorylation regulation of catalytic activity regulation of protein phosphorylation positive regulation of protein metabolic process regulation of transferase activity positive regulation of phosphate metabolic process positive regulation of protein serine/threonine kinase activity positive regulation of metabolic process positive regulation of molecular function positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein kinase activity phosphorus metabolic process protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of transferase activity positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of catalytic activity regulation of protein kinase activity regulation of molecular function positive regulation of kinase activity regulation of kinase activity macromolecule modification regulation of protein serine/threonine kinase activity regulation of phosphorylation regulation of phosphorus metabolic process branching involved in mammary gland duct morphogenesis mammary gland morphogenesis mammary gland development branching morphogenesis of an epithelial tube gland development tube morphogenesis gland morphogenesis epithelial tube morphogenesis morphogenesis of an epithelium mammary gland duct morphogenesis tissue morphogenesis mammary gland epithelium development morphogenesis of a branching structure morphogenesis of a branching epithelium negative regulation of signaling regulation of signal transduction extrinsic apoptotic signaling pathway negative regulation of cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway regulation of signaling negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of cell communication regulation of apoptotic signaling pathway myeloid leukocyte differentiation hemopoiesis osteoclast development skeletal system development myeloid cell differentiation bone cell development osteoclast differentiation myeloid cell development bone development leukocyte differentiation RNA metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II gene expression regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process epithelium migration tissue migration ameboidal-type cell migration regulation of multicellular organismal process epithelial cell migration regulation of epithelial cell migration protein-containing complex organization signal complex assembly protein-containing complex assembly positive regulation of dephosphorylation regulation of dephosphorylation dephosphorylation positive regulation of response to biotic stimulus pattern recognition receptor signaling pathway response to biotic stimulus intracellular signal transduction immune response-activating signaling pathway positive regulation of immune response positive regulation of immune system process innate immune response-activating signaling pathway response to other organism regulation of innate immune response defense response to other organism regulation of pattern recognition receptor signaling pathway positive regulation of defense response activation of innate immune response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of response to biotic stimulus intracellular receptor signaling pathway regulation of cytoplasmic pattern recognition receptor signaling pathway positive regulation of response to stimulus positive regulation of response to external stimulus endolysosomal toll-like receptor signaling pathway immune response-regulating signaling pathway regulation of intracellular signal transduction innate immune response response to external biotic stimulus regulation of toll-like receptor 3 signaling pathway positive regulation of innate immune response defense response to symbiont toll-like receptor 3 signaling pathway cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to transforming growth factor beta stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway ovulation cycle process developmental growth reproductive process sex differentiation development of primary female sexual characteristics developmental process involved in reproduction ovulation cycle development of primary sexual characteristics reproductive structure development ovarian follicle development rhythmic process gonad development reproductive system development female gonad development multicellular organismal reproductive process growth female sex differentiation primary ovarian follicle growth ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process organophosphate catabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process regulation of ATP metabolic process regulation of purine nucleotide catabolic process positive regulation of nucleotide catabolic process regulation of small molecule metabolic process glycolytic process regulation of nucleotide metabolic process pyridine-containing compound metabolic process small molecule metabolic process purine ribonucleotide catabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process regulation of carbohydrate catabolic process positive regulation of nucleobase-containing compound metabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process positive regulation of ATP metabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process positive regulation of carbohydrate metabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process ATP metabolic process catabolic process positive regulation of nucleotide metabolic process positive regulation of purine nucleotide catabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process ribonucleoside triphosphate metabolic process nucleotide catabolic process purine nucleoside triphosphate metabolic process carbohydrate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process positive regulation of glycolytic process ADP catabolic process carboxylic acid metabolic process generation of precursor metabolites and energy regulation of catabolic process regulation of glycolytic process purine-containing compound metabolic process positive regulation of purine nucleotide metabolic process positive regulation of catabolic process ADP metabolic process organophosphate metabolic process purine ribonucleoside diphosphate metabolic process positive regulation of small molecule metabolic process purine ribonucleoside diphosphate catabolic process sexual reproduction oogenesis cellular process involved in reproduction in multicellular organism female gamete generation gamete generation germ cell development positive regulation of cell communication positive regulation of signal transduction positive regulation of ERK1 and ERK2 cascade intracellular signaling cassette positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling monosaccharide metabolic process hexose metabolic process positive regulation of glucose metabolic process regulation of glucose metabolic process glucose metabolic process regulation of localization cellular localization transport regulation of transport intracellular transport regulation of vesicle-mediated transport establishment of localization vesicle-mediated transport endosomal transport vesicle-mediated transport between endosomal compartments regulation of early endosome to late endosome transport localization early endosome to late endosome transport regulation of cellular localization establishment of localization in cell regulation of intracellular transport neutrophil activation regulation of leukocyte activation regulation of neutrophil activation negative regulation of neutrophil activation regulation of cell activation myeloid leukocyte activation leukocyte activation negative regulation of cell activation negative regulation of multicellular organismal process negative regulation of leukocyte activation granulocyte activation positive regulation of cellular component organization positive regulation of cellular component biogenesis positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly regulation of integrin activation integrin activation positive regulation of integrin activation positive regulation of cell population proliferation regulation of reproductive process regulation of male germ cell proliferation germ cell proliferation regulation of germ cell proliferation positive regulation of reproductive process positive regulation of germ cell proliferation positive regulation of male germ cell proliferation male germ cell proliferation regulation of cell population proliferation positive regulation of multicellular organismal process uterus development head development forebrain development brain development nervous system development central nervous system development macroautophagy autophagy process utilizing autophagic mechanism interleukin-6-mediated signaling pathway response to interleukin-6 cellular response to interleukin-6 response to cytokine cytokine-mediated signaling pathway response to peptide cellular response to cytokine stimulus leukocyte migration neurotrophin TRK receptor signaling pathway neurotrophin signaling pathway positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process cytokine production regulation of cytokine production positive regulation of gene expression positive regulation of cytokine production response to insulin cellular response to insulin stimulus regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway positive regulation of Wnt signaling pathway Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of gene expression small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction positive regulation of small GTPase mediated signal transduction vascular endothelial growth factor receptor signaling pathway immune response-regulating cell surface receptor signaling pathway involved in phagocytosis import into cell immune response-regulating cell surface receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis Fc receptor signaling pathway phagocytosis Fc-gamma receptor signaling pathway immune response-activating cell surface receptor signaling pathway Fc receptor mediated stimulatory signaling pathway immune effector process endocytosis peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation peptidyl-amino acid modification regulation of peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation positive regulation of epithelial cell migration adherens junction organization cell junction organization cell-cell junction organization regulation of developmental process regulation of ovarian follicle development positive regulation of developmental process positive regulation of ovarian follicle development spermatogenesis male gamete generation protein destabilization regulation of protein stability response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus response to ketone response to lipid response to progesterone cellular response to progesterone stimulus response to steroid hormone cellular response to lipid cellular response to ketone cellular response to steroid hormone stimulus ephrin receptor signaling pathway positive regulation of programmed cell death positive regulation of apoptotic process actomyosin structure organization actin cytoskeleton organization actin filament organization actin filament bundle organization contractile actin filament bundle assembly actin filament-based process actin filament bundle assembly stress fiber assembly supramolecular fiber organization cytoskeleton organization regulation of vascular permeability system process circulatory system process vascular process in circulatory system blood circulation response to angiotensin angiotensin-activated signaling pathway cellular response to angiotensin G protein-coupled receptor signaling pathway response to corticosteroid response to mineralocorticoid negative regulation of protein-containing complex assembly homeostatic process regulation of bone remodeling tissue homeostasis regulation of tissue remodeling regulation of bone resorption bone resorption multicellular organismal-level homeostasis tissue remodeling bone remodeling anatomical structure homeostasis protein autophosphorylation response to electrical stimulus insulin receptor signaling pathway regulation of cellular response to insulin stimulus positive regulation of cellular response to insulin stimulus regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway ERBB signaling pathway epidermal growth factor receptor signaling pathway hippo signaling negative regulation of intracellular signal transduction negative regulation of hippo signaling regulation of hippo signaling focal adhesion assembly cell-substrate junction assembly cell-matrix adhesion cell junction assembly cell-substrate junction organization positive regulation of bone resorption progesterone receptor signaling pathway hormone-mediated signaling pathway nuclear receptor-mediated steroid hormone signaling pathway steroid hormone receptor signaling pathway nuclear receptor-mediated signaling pathway positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation T cell activation positive regulation of leukocyte activation positive regulation of T cell activation positive regulation of cell adhesion regulation of T cell activation lymphocyte costimulation regulation of leukocyte cell-cell adhesion T cell costimulation regulation of lymphocyte activation positive regulation of organelle organization positive regulation of podosome assembly membraneless organelle assembly regulation of podosome assembly organelle assembly podosome assembly regulation of organelle assembly positive regulation of organelle assembly response to nutrient levels response to pH response to acidic pH heart process regulation of heart contraction regulation of system process regulation of blood circulation cardiac conduction regulation of heart rate by cardiac conduction heart contraction regulation of heart rate protein localization regulation of protein localization positive regulation of protein localization to nucleus regulation of protein localization to nucleus protein localization to nucleus cellular macromolecule localization macromolecule localization protein localization to organelle positive regulation of protein localization negative regulation of cell-substrate junction organization negative regulation of cell-matrix adhesion negative regulation of cell adhesion negative regulation of cell junction assembly regulation of cell-substrate junction organization regulation of cell-substrate adhesion negative regulation of focal adhesion assembly regulation of cell junction assembly regulation of cell-matrix adhesion negative regulation of cell-substrate adhesion regulation of focal adhesion assembly regulation of cell-substrate junction assembly cellular response to platelet-derived growth factor stimulus response to platelet-derived growth factor regulation of platelet-derived growth factor receptor signaling pathway positive regulation of platelet-derived growth factor receptor-beta signaling pathway positive regulation of platelet-derived growth factor receptor signaling pathway platelet-derived growth factor receptor-beta signaling pathway regulation of platelet-derived growth factor receptor-beta signaling pathway establishment of protein localization nitrogen compound transport positive regulation of establishment of protein localization positive regulation of protein transport regulation of establishment of protein localization regulation of protein transport positive regulation of transport protein transport regulation of intracellular estrogen receptor signaling pathway regulation of intracellular steroid hormone receptor signaling pathway estrogen receptor signaling pathway integrin-mediated signaling pathway caveolin-mediated endocytosis regulation of caveolin-mediated endocytosis regulation of endocytosis response to interleukin-1 regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell proliferation regulation of smooth muscle cell proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation muscle cell proliferation vascular associated smooth muscle cell proliferation cellular response to lipopolysaccharide cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to biotic stimulus response to bacterium response to molecule of bacterial origin regulation of protein maturation positive regulation of protein maturation positive regulation of protein processing protein maturation regulation of proteolysis proteolysis positive regulation of proteolysis regulation of protein processing protein processing response to lectin cellular response to lectin innate immune response activating cell surface receptor signaling pathway stimulatory C-type lectin receptor signaling pathway regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of intrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway positive regulation of TORC1 signaling positive regulation of TOR signaling regulation of TORC1 signaling TOR signaling regulation of TOR signaling TORC1 signaling cellular response to oxidative stress cellular response to chemical stress cellular response to hydrogen peroxide response to reactive oxygen species response to hydrogen peroxide response to oxidative stress cellular response to reactive oxygen species ERBB2 signaling pathway response to mechanical stimulus cellular response to prolactin response to prolactin transcytosis behavior learning or memory nervous system process cognition plasma membrane bounded cell projection morphogenesis cell morphogenesis regulation of cell morphogenesis cell projection morphogenesis regulation of lamellipodium organization regulation of lamellipodium morphogenesis positive regulation of cell projection organization regulation of anatomical structure morphogenesis plasma membrane bounded cell projection organization positive regulation of lamellipodium morphogenesis positive regulation of lamellipodium organization lamellipodium organization lamellipodium morphogenesis regulation of plasma membrane bounded cell projection organization response to fatty acid cellular response to fatty acid Notch signaling pathway regulation of Notch signaling pathway positive regulation of Notch signaling pathway regulation of Ras protein signal transduction positive regulation of Ras protein signal transduction Ras protein signal transduction skeletal muscle cell proliferation striated muscle cell proliferation	cell-cell junction cellular anatomical structure anchoring junction cell junction intracellular organelle intracellular anatomical structure podosome cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm cytosol cell-cell junction cellular anatomical structure anchoring junction cell junction intracellular organelle intracellular anatomical structure podosome cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm cytosol somatodendritic compartment cell projection actin-based cell projection dendritic filopodium dendrite dendritic tree filopodium neuron projection plasma membrane bounded cell projection polymeric cytoskeletal fiber actin filament supramolecular fiber supramolecular polymer supramolecular complex membrane-bounded organelle mitochondrial membrane organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane focal adhesion cell-substrate junction cell periphery plasma membrane synapse plasma membrane region synaptic membrane ruffle cell leading edge leading edge membrane ruffle membrane cell projection membrane membrane microdomain membrane raft plasma membrane raft caveola lytic vacuole vacuole lysosome postsynaptic specialization postsynaptic specialization, intracellular component postsynapse endosome intracellular vesicle endomembrane system cytoplasmic vesicle late endosome vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle dendrite terminus axon growth cone distal axon dendritic growth cone site of polarized growth glutamatergic synapse perinuclear region of cytoplasm cell body neuronal cell body nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
A	IPR000719	Protein kinase domain	Domain
A	IPR017441	Protein kinase, ATP binding site	Binding Site
A	IPR036860	SH2 domain superfamily	Homologous Superfamily
A	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
A	IPR008266	Tyrosine-protein kinase, active site	Active Site
A	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A	IPR001452	SH3 domain	Domain
A	IPR000980	SH2 domain	Domain
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR050198	Non-receptor tyrosine kinases involved in cell signaling	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P12931	urinary bladder cancer autosomal recessive polycystic kidney disease thrombocytopenia 6 status epilepticus colorectal cancer breast carcinoma Neoplasm Invasiveness malignant colon neoplasm cancer colitis hematologic disease lung disease autosomal dominant polycystic kidney disease medulloblastoma osteosarcoma urinary bladder cancer autosomal recessive polycystic kidney disease thrombocytopenia 6 status epilepticus colorectal cancer breast carcinoma Neoplasm Invasiveness malignant colon neoplasm cancer colitis hematologic disease lung disease autosomal dominant polycystic kidney disease medulloblastoma osteosarcoma psoriasis chronic obstructive pulmonary disease colon carcinoma colorectal carcinoma intestinal disease lymphatic system disease bone disease ovarian cancer breast disease urinary bladder neoplasm colonic neoplasm liver disease benign colon neoplasm breast cancer prostate disease tuberculosis

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	PTR	Parent Component: TYR RESID: AA0039 PSI-MOD : O4'-phospho-L-tyrosine MOD:00048

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.