7ZW3

Crystal Structure of human MAO B in complex with (Z)-N-benzyl-1-(8-hydroxyquinolin-2-yl)methanimine oxide (inhibitor 19)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth AAA]	SCOP2B Superfamily	Flavoreductase-like	8001424	3000055	SCOP2B (2022-06-29)
B [auth BBB]	SCOP2B Superfamily	Flavoreductase-like	8001424	3000055	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth AAA]	F_UNCLASSIFIED	e7zw3AAA2	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: F_UNCLASSIFIED	ECOD (1.6)
A [auth AAA]	F_UNCLASSIFIED	e7zw3AAA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth BBB]	F_UNCLASSIFIED	e7zw3BBB2	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth BBB]	F_UNCLASSIFIED	e7zw3BBB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth AAA], B [auth BBB]	PF01593	Flavin containing amine oxidoreductase (Amino_oxidase)	Flavin containing amine oxidoreductase	This family consists of various amine oxidases, including maze polyamine oxidase (PAO) [1] and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene ...	This family consists of various amine oxidases, including maze polyamine oxidase (PAO) [1] and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines [2]. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium [3]. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines [1]. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth AAA], B [auth BBB]	Amine oxidase [flavin-containing] B	monoamine oxidase activity oxidoreductase activity, acting on the CH-NH2 group of donors oxidoreductase activity oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor catalytic activity flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding anion binding nucleotide binding heterocyclic compound binding small molecule binding electron transfer activity monoamine oxidase activity oxidoreductase activity, acting on the CH-NH2 group of donors oxidoreductase activity oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor catalytic activity flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding anion binding nucleotide binding heterocyclic compound binding small molecule binding electron transfer activity aliphatic amine oxidase activity aliphatic amine dehydrogenase activity primary methylamine oxidase activity identical protein binding protein binding	response to stimulus response to chemical response to xenobiotic stimulus monoamine transport regulation of localization nitrogen compound transport regulation of cellular process transport signaling negative regulation of monoatomic ion transport negative regulation of biological process negative regulation of transport organic hydroxy compound transport cell communication response to stimulus response to chemical response to xenobiotic stimulus monoamine transport regulation of localization nitrogen compound transport regulation of cellular process transport signaling negative regulation of monoatomic ion transport negative regulation of biological process negative regulation of transport organic hydroxy compound transport cell communication localization secretion by cell negative regulation of secretion regulation of secretion by cell signal release negative regulation of cellular process monoatomic ion transport negative regulation of secretion by cell serotonin secretion negative regulation of serotonin secretion regulation of biological process regulation of transport secretion regulation of monoatomic ion transport biological regulation cell-cell signaling export from cell serotonin transport regulation of serotonin secretion establishment of localization regulation of secretion cellular process response to selenium ion positive regulation of biological process dopamine metabolic process catechol-containing compound metabolic process regulation of primary metabolic process positive regulation of metabolic process catecholamine metabolic process positive regulation of amine metabolic process positive regulation of cellular process regulation of dopamine metabolic process positive regulation of catecholamine metabolic process regulation of amine metabolic process primary metabolic process positive regulation of dopamine metabolic process amine metabolic process phenol-containing compound metabolic process metabolic process regulation of catecholamine metabolic process regulation of metabolic process biogenic amine metabolic process response to toxic substance response to ketone response to lipid response to endogenous stimulus response to alcohol response to glucocorticoid response to oxygen-containing compound response to corticosterone response to mineralocorticoid response to corticosteroid response to hormone response to steroid hormone response to ethanol developmental process multicellular organismal process head development animal organ development brain development nervous system development substantia nigra development multicellular organism development central nervous system development midbrain development anatomical structure development neural nucleus development system development reactive oxygen species biosynthetic process biosynthetic process reactive oxygen species metabolic process hydrogen peroxide metabolic process hydrogen peroxide biosynthetic process phenylethylamine catabolic process catabolic process primary amino compound metabolic process biogenic amine catabolic process phenylethylamine metabolic process primary amino compound catabolic process amine catabolic process catecholamine catabolic process catechol-containing compound catabolic process phenol-containing compound catabolic process dopamine catabolic process response to metal ion response to aluminum ion biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to lipopolysaccharide response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection organelle envelope mitochondrial envelope mitochondrial membrane membrane organelle outer membrane bounding membrane of organelle mitochondrial outer membrane outer membrane organelle membrane cell body neuronal cell body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth AAA], B [auth BBB]	IPR002937	Amine oxidase	Domain
A [auth AAA], B [auth BBB]	IPR036188	FAD/NAD(P)-binding domain superfamily	Homologous Superfamily
A [auth AAA], B [auth BBB]	IPR050703	Flavin Monoamine Oxidase	Family
A [auth AAA], B [auth BBB]	IPR001613	Flavin amine oxidase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth AAA], B [auth BBB]	Pharos: P27338	Alzheimer disease Parkinson disease Huntington disease malignant colon neoplasm megaloblastic anemia hepatic encephalopathy major depressive disorder hepatic coma Pheochromocytoma endometriosis schizophrenia depressive disorder pilocytic astrocytoma extra-adrenal sympathetic paraganglioma head and neck cancer Alzheimer disease Parkinson disease Huntington disease malignant colon neoplasm megaloblastic anemia hepatic encephalopathy major depressive disorder hepatic coma Pheochromocytoma endometriosis schizophrenia depressive disorder pilocytic astrocytoma extra-adrenal sympathetic paraganglioma head and neck cancer hypertensive disorder intellectual disability large cell medulloblastoma medulloblastoma autism bipolar disorder pancreatic ductal adenocarcinoma colonic neoplasm phaeochromocytoma pituitary cancer psoriasis sinusitis adrenal gland pheochromocytoma invasive ductal breast carcinoma lung adenocarcinoma non-small cell lung carcinoma breast cancer cystic fibrosis toxic encephalopathy hypotensive disorder juvenile Huntington disease lung cancer malignant ependymoma atypical teratoid rhabdoid tumor benign colon neoplasm ovarian cancer breast carcinoma

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth AAA], B [auth BBB]	OPM	Transmembrane	Bitopic proteins	Bitopic proteins with NAD(P)-binding Rossmann-fold domains	Flavin containing amine oxidoreductase

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.