7WEK | pdb_00007wek

Crystal structure of the mouse Wdr47 NTD in complex with the WBR motif form Camsap3.

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF17814	LisH-like dimerisation domain (LisH_TPL)	LisH-like dimerisation domain	TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	WD repeat-containing protein 47	protein-containing complex binding binding	developmental process corpus callosum development multicellular organismal process head development forebrain development animal organ development brain development nervous system development multicellular organism development central nervous system development anatomical structure development telencephalon development system development behavior developmental process corpus callosum development multicellular organismal process head development forebrain development animal organ development brain development nervous system development multicellular organism development central nervous system development anatomical structure development telencephalon development system development behavior locomotory behavior adult locomotory behavior adult behavior catabolic process autophagy cellular process metabolic process process utilizing autophagic mechanism detection of external stimulus sensory perception of hot stimulus system process thermoception response to stimulus nervous system process response to external stimulus sensory perception of temperature stimulus detection of temperature stimulus involved in sensory perception response to temperature stimulus detection of abiotic stimulus detection of stimulus sensory perception detection of temperature stimulus involved in thermoception detection of temperature stimulus detection of hot stimulus involved in thermoception response to abiotic stimulus detection of stimulus involved in sensory perception pallium development cerebral cortex development axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development central nervous system neuron development neuron projection development cell morphogenesis cellular component organization neurogenesis central nervous system neuron differentiation cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation cellular component organization or biogenesis central nervous system projection neuron axonogenesis central nervous system neuron axonogenesis plasma membrane bounded cell projection organization axon development cell morphogenesis involved in neuron differentiation generation of neurons anterior commissure morphogenesis anatomical structure morphogenesis neuron development cell population proliferation neural precursor cell proliferation glial cell migration telencephalon glial cell migration telencephalon cell migration forebrain cell migration gliogenesis cell migration cell motility cerebral cortex cell migration cerebral cortex radially oriented cell migration cerebral cortex radial glia-guided migration organelle organization microtubule cytoskeleton organization microtubule-based process cytoskeleton organization motor behavior regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization regulation of cellular component organization regulation of cellular process negative regulation of microtubule depolymerization negative regulation of biological process protein-containing complex disassembly regulation of protein-containing complex disassembly microtubule polymerization or depolymerization regulation of microtubule depolymerization negative regulation of protein-containing complex disassembly negative regulation of cellular process negative regulation of supramolecular fiber organization cellular component disassembly regulation of biological process negative regulation of cellular component organization negative regulation of microtubule polymerization or depolymerization protein-containing complex organization regulation of protein depolymerization negative regulation of cytoskeleton organization biological regulation regulation of microtubule-based process regulation of organelle organization negative regulation of protein depolymerization negative regulation of organelle organization microtubule depolymerization regulation of supramolecular fiber organization supramolecular fiber organization protein depolymerization regulation of microtubule cytoskeleton organization neuronal stem cell population maintenance maintenance of cell number stem cell population maintenance	somatodendritic compartment cell projection cellular anatomical structure dendrite dendritic tree neuron projection plasma membrane bounded cell projection intracellular anatomical structure cytoplasm growth cone axon distal axon site of polarized growth cell body somatodendritic compartment cell projection cellular anatomical structure dendrite dendritic tree neuron projection plasma membrane bounded cell projection intracellular anatomical structure cytoplasm growth cone axon distal axon site of polarized growth cell body neuronal cell body polymeric cytoskeletal fiber intracellular membraneless organelle intracellular organelle cytoskeleton organelle membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton
C, D	WBR motif form Calmodulin-regulated spectrin-associated protein 3	cytoskeletal protein binding microtubule binding protein binding binding microtubule minus-end binding tubulin binding spectrin binding protein-containing complex binding actin binding actin filament binding calmodulin binding	regulation of cellular process regulation of cellular component organization cell-substrate junction assembly cellular component organization cellular component biogenesis cell adhesion cellular component assembly cell junction assembly regulation of cell-substrate junction organization cellular component organization or biogenesis focal adhesion assembly regulation of biological process regulation of cell-substrate adhesion regulation of cell adhesion regulation of cellular process regulation of cellular component organization cell-substrate junction assembly cellular component organization cellular component biogenesis cell adhesion cellular component assembly cell junction assembly regulation of cell-substrate junction organization cellular component organization or biogenesis focal adhesion assembly regulation of biological process regulation of cell-substrate adhesion regulation of cell adhesion biological regulation cell-substrate adhesion regulation of cellular component biogenesis regulation of cell junction assembly cell junction organization cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization cellular process regulation of focal adhesion assembly regulation of cell-substrate junction assembly cell-cell adhesion epithelial cell-cell adhesion adherens junction organization cellular component maintenance adherens junction maintenance cell junction maintenance zonula adherens maintenance cell-cell junction organization cell-cell junction maintenance polarized epithelial cell differentiation establishment of monopolar cell polarity establishment or maintenance of monopolar cell polarity cellular developmental process establishment or maintenance of cell polarity epithelial cell differentiation morphogenesis of a polarized epithelium cell differentiation anatomical structure development establishment or maintenance of apical/basal cell polarity developmental process establishment or maintenance of bipolar cell polarity epithelium development establishment of epithelial cell apical/basal polarity morphogenesis of an epithelium tissue development establishment of cell polarity tissue morphogenesis anatomical structure morphogenesis establishment or maintenance of epithelial cell apical/basal polarity establishment of apical/basal cell polarity establishment of epithelial cell polarity organelle organization microtubule cytoskeleton organization microtubule-based process microtubule anchoring cytoskeleton organization regulation of cell motility regulation of locomotion regulation of cell migration cell migration cell motility locomotion multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development regulation of cytoskeleton organization regulation of microtubule-based process regulation of organelle organization regulation of microtubule cytoskeleton organization regulation of microtubule polymerization or depolymerization regulation of protein-containing complex assembly microtubule polymerization or depolymerization protein-containing complex assembly protein polymerization protein-containing complex organization microtubule polymerization regulation of microtubule polymerization regulation of protein polymerization regulation of supramolecular fiber organization supramolecular fiber organization microtubule-based movement cilium movement protein localization establishment of protein localization cellular localization nitrogen compound transport transport protein transport along microtubule microtubule-based protein transport intracellular transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization establishment of localization in cell microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport intracellular protein transport establishment or maintenance of microtubule cytoskeleton polarity establishment or maintenance of cytoskeleton polarity regulation of Golgi organization Golgi organization endomembrane system organization plasma membrane bounded cell projection organization cell projection organization cell development neuron projection development nervous system development generation of neurons neurogenesis neuron differentiation neuron development system development	membrane-bounded organelle intracellular anatomical structure axoneme ciliary plasm cilium intracellular membraneless organelle cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection intracellular organelle cell projection cellular anatomical structure cytoskeleton organelle membrane-bounded organelle intracellular anatomical structure axoneme ciliary plasm cilium intracellular membraneless organelle cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection intracellular organelle cell projection cellular anatomical structure cytoskeleton organelle membraneless organelle cytoplasm centrosome microtubule organizing center microtubule cytoskeleton polymeric cytoskeletal fiber microtubule end microtubule minus-end supramolecular fiber microtubule supramolecular polymer supramolecular complex motile cilium cell-cell junction apical junction complex adherens junction anchoring junction cell junction zonula adherens ciliary basal body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR054532	TPL/SMU1, LisH-like dimerisation domain	Domain
A, B	IPR019775	WD40 repeat, conserved site	Conserved Site
A, B	IPR040067	WD repeat-containing protein 47	Family
A, B	IPR006595	CTLH, C-terminal LisH motif	Domain
A, B	IPR006594	LIS1 homology motif	Conserved Site
A, B	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A, B	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A, B	IPR001680	WD40 repeat	Repeat
C, D	IPR038209	CKK domain superfamily	Homologous Superfamily
C, D	IPR031372	CAMSAP, spectrin and Ca2+/calmodulin-binding region	Conserved Site
C, D	IPR001715	Calponin homology domain	Domain
C, D	IPR032940	Calmodulin-regulated spectrin-associated protein	Family
C, D	IPR014797	CKK domain	Domain
C, D	IPR036872	CH domain superfamily	Homologous Superfamily
C, D	IPR022613	Calmodulin-regulated spectrin-associated protein-like, Calponin-homology domain	Domain
C, D	IPR011033	PRC-barrel-like superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.