7S5F

Crystal structure of mannose-6-phosphate reductase from celery (Apium graveolens) leaves with NADP+ and mannonic acid bound

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2B Superfamily	NAD(P)-linked oxidoreductase	8106788	3000288	SCOP2B (2022-06-29)
B [auth A]	SCOP2B Superfamily	NAD(P)-linked oxidoreductase	8106788	3000288	SCOP2B (2022-06-29)
C	SCOP2 Family	Aldo-keto reductases (NADP)	8106787	4003124	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	NAD(P)-linked oxidoreductase	8106788	3000288	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	NAD(P)-linked oxidoreductase	8106788	3000288	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	Aldo_ket_red	e7s5fB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldo_ket_red	ECOD (1.6)
B [auth A]	Aldo_ket_red	e7s5fA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldo_ket_red	ECOD (1.6)
C	Aldo_ket_red	e7s5fC1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldo_ket_red	ECOD (1.6)
D	Aldo_ket_red	e7s5fD1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldo_ket_red	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A], C, D	PF00248	Aldo/keto reductase family (Aldo_ket_red)	Aldo/keto reductase family	This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A], C, D	Manose-6-phosphate reductase	oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors catalytic activity aldose-6-phosphate reductase (NADPH) activity binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A], C, D	IPR018170	Aldo/keto reductase, conserved site	Conserved Site
A [auth B], B [auth A], C, D	IPR036812	NADP-dependent oxidoreductase domain superfamily	Homologous Superfamily
A [auth B], B [auth A], C, D	IPR044485	Aldo-keto reductase family 2A	Family
A [auth B], B [auth A], C, D	IPR023210	NADP-dependent oxidoreductase domain	Domain
A [auth B], B [auth A], C, D	IPR020471	Aldo-keto reductase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.