7PR6

Crystal structure of E. coli beta-glucuronidase in complex with covalent inhibitor ME727


Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
B [auth BBB]Glyco_hydro_2_Ne7pr6BBB2 A: beta sandwichesX: jelly-rollH: Concanavalin A-likeT: Galactose-binding domain-likeF: Glyco_hydro_2_NECOD (1.6)
B [auth BBB]Glyco_hydro_2e7pr6BBB1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: Glyco_hydro_2ECOD (1.6)
B [auth BBB]Glyco_hydro_2_Ce7pr6BBB3 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: Glyco_hydro_2_CECOD (1.6)
A [auth AAA]Glyco_hydro_2_Ne7pr6AAA1 A: beta sandwichesX: jelly-rollH: Concanavalin A-likeT: Galactose-binding domain-likeF: Glyco_hydro_2_NECOD (1.6)
A [auth AAA]Glyco_hydro_2e7pr6AAA2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: Glyco_hydro_2ECOD (1.6)
A [auth AAA]Glyco_hydro_2_Ce7pr6AAA3 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: Glyco_hydro_2_CECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth AAA],
B [auth BBB]
PF02836Glycosyl hydrolases family 2, TIM barrel domain (Glyco_hydro_2_C)Glycosyl hydrolases family 2, TIM barrel domainThis family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities.Domain
A [auth AAA],
B [auth BBB]
PF00703Glycosyl hydrolases family 2 (Glyco_hydro_2)Glycosyl hydrolases family 2This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities.Domain
A [auth AAA],
B [auth BBB]
PF02837Glycosyl hydrolases family 2, sugar binding domain (Glyco_hydro_2_N)Glycosyl hydrolases family 2, sugar binding domainThis family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities and has a jelly-roll fold. The domain binds the sugar moiety during the sugar-hydrolysis reaction.Domain