7PP1 | pdb_00007pp1

Crystal structure of the P2Y12 receptor in complex with the inverse agonist selatogrel.

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth AAA]	SCOP2B Superfamily	G protein-coupled receptor-like	8091252	3000473	SCOP2B (2022-06-29)
A [auth AAA]	SCOP2B Superfamily	Cytochromes	8057879	3001526	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth AAA]	7tm_1_1	e7pp1AAA1	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_1	ECOD (1.6)
A [auth AAA]	Cytochrom_B562_1	e7pp1AAA2	A: alpha bundles	X: Four-helical up-and-down bundle	H: Cytochromes (From Topology)	T: Cytochromes	F: Cytochrom_B562_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth AAA]	PF07361	Cytochrome b562 (Cytochrom_B562)	Cytochrome b562	-	Family
A [auth AAA]	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GC ...	This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth AAA]	P2Y purinoceptor 12,Soluble cytochrome b562,P2Y purinoceptor 12	binding tetrapyrrole binding heme binding electron transfer activity cation binding transition metal ion binding iron ion binding ion binding metal ion binding small molecule binding molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity binding tetrapyrrole binding heme binding electron transfer activity cation binding transition metal ion binding iron ion binding ion binding metal ion binding small molecule binding molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity G protein-coupled adenosine receptor activity G protein-coupled ADP receptor activity G protein-coupled purinergic nucleotide receptor activity purinergic nucleotide receptor activity nucleotide receptor activity enzyme regulator activity guanyl nucleotide binding GTP binding nucleotide binding hydrolase activity guanyl ribonucleotide binding GDP binding purine ribonucleotide binding ribonucleoside triphosphate phosphatase activity anion binding molecular function regulator activity heterocyclic compound binding carbohydrate derivative binding hydrolase activity, acting on acid anhydrides catalytic activity ribonucleotide binding pyrophosphatase activity GTPase activity nucleoside-triphosphatase regulator activity GTPase regulator activity purine ribonucleoside triphosphate binding guanyl-nucleotide exchange factor activity nucleoside phosphate binding purine nucleotide binding hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	electron transport chain metabolic process cellular process generation of precursor metabolites and energy regulation of localization regulation of biological process transport regulation of transport regulation of monoatomic ion transport biological regulation positive regulation of biological process establishment of localization localization positive regulation of transport electron transport chain metabolic process cellular process generation of precursor metabolites and energy regulation of localization regulation of biological process transport regulation of transport regulation of monoatomic ion transport biological regulation positive regulation of biological process establishment of localization localization positive regulation of transport positive regulation of monoatomic ion transport monoatomic ion transport response to stimulus response to stress response to wounding response to axon injury regulation of body fluid levels hemostasis regulation of biological quality chemotaxis regulation of response to external stimulus response to external stimulus regulation of chemotaxis taxis regulation of response to stimulus response to chemical regulation of locomotion locomotion positive regulation of locomotion multicellular organismal process regulation of cell motility regulation of cellular process cellular developmental process regulation of microglial cell migration glial cell migration macrophage migration regulation of glial cell migration positive regulation of cell migration neurogenesis multicellular organism development regulation of macrophage migration gliogenesis cell differentiation positive regulation of cell motility regulation of cell migration myeloid leukocyte migration positive regulation of mononuclear cell migration anatomical structure development positive regulation of microglial cell migration cell migration regulation of immune system process regulation of mononuclear cell migration cell motility positive regulation of immune system process positive regulation of cellular process system development developmental process positive regulation of macrophage migration regulation of leukocyte migration microglial cell migration positive regulation of leukocyte migration nervous system development leukocyte migration positive regulation of glial cell migration immune system process mononuclear cell migration lamellipodium assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component organization cellular component biogenesis cellular component assembly lamellipodium organization cellular component organization or biogenesis cell projection assembly positive regulation of chemotaxis positive regulation of response to stimulus positive regulation of response to external stimulus wound healing homotypic cell-cell adhesion cell activation platelet aggregation blood coagulation cell adhesion cell-cell adhesion coagulation platelet activation visual system development sensory system development cellular response to stimulus positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signal transduction signaling regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of cell communication phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling calcium-mediated signaling substrate-dependent cell migration, cell extension substrate-dependent cell migration cellular localization establishment of localization in cell positive regulation of cell adhesion mediated by integrin positive regulation of cell adhesion regulation of cell adhesion mediated by integrin regulation of cell adhesion cell adhesion mediated by integrin positive regulation of cellular component organization regulation of cellular component organization positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly protein-containing complex assembly regulation of integrin activation positive regulation of integrin activation cell surface receptor signaling pathway protein-containing complex organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis positive regulation of integrin activation by cell surface receptor linked signal transduction integrin activation phospholipase C-activating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway forebrain development telencephalon glial cell migration cerebral cortex development telencephalon cell migration forebrain cell migration cerebral cortex cell migration head development animal organ development brain development cerebral cortex radially oriented cell migration pallium development central nervous system development cerebral cortex radial glia-guided migration telencephalon development cellular response to nitrogen compound cellular response to ATP response to organophosphorus response to oxygen-containing compound response to nitrogen compound response to ATP response to purine-containing compound cellular response to oxygen-containing compound cellular response to chemical stimulus ruffle organization ruffle assembly positive regulation of cell projection organization regulation of cell projection organization regulation of cell projection assembly positive regulation of ruffle assembly regulation of plasma membrane bounded cell projection assembly regulation of ruffle assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly	cellular anatomical structure periplasmic space cell periphery cell body cell body membrane plasma membrane membrane cell surface cell projection plasma membrane region cell projection membrane plasma membrane bounded cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth AAA]	IPR010980	Cytochrome c/b562	Homologous Superfamily
A [auth AAA]	IPR009155	Cytochrome b562	Family
A [auth AAA]	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
A [auth AAA]	IPR017452	GPCR, rhodopsin-like, 7TM	Domain
A [auth AAA]	IPR005394	P2Y12 purinoceptor	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth AAA]	Pharos: Q9H244	platelet-type bleeding disorder 8 myocardial infarction cerebrovascular disorder thrombotic disease Hemorrhage large cell medulloblastoma malignant pancreatic neoplasm non-small cell lung carcinoma acute coronary syndrome atrial fibrillation pilocytic astrocytoma coronary artery disease Sjogren syndrome gastric cancer head and neck cancer platelet-type bleeding disorder 8 myocardial infarction cerebrovascular disorder thrombotic disease Hemorrhage large cell medulloblastoma malignant pancreatic neoplasm non-small cell lung carcinoma acute coronary syndrome atrial fibrillation pilocytic astrocytoma coronary artery disease Sjogren syndrome gastric cancer head and neck cancer tuberculosis intracranial embolism MALT lymphoma oligodendroglioma atypical teratoid rhabdoid tumor pituitary cancer primitive neuroectodermal tumor ductal breast carcinoma in situ gastric carcinoma invasive ductal breast carcinoma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma adrenal cortex carcinoma peripheral vascular disease breast cancer chronic obstructive pulmonary disease sarcoidosis exocrine pancreatic carcinoma systemic lupus erythematosus glioblastoma hepatocellular carcinoma

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth AAA]	OPM	Transmembrane	Alpha-helical polytopic	Rhodopsin-like receptors and pumps	G-protein coupled receptors, family A

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A [auth AAA]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class A	P2Y₁₂ receptor with bound inverse agonist selatogrel

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.