Annotations: 7JZX

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth C]	SCOP2B Superfamily	CRISPR-associated proteins	8052171	3001554	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	Cas_Csy4_C	e7jzxC2	A: a+b two layers	X: Alpha-beta plaits	H: CRISPR transcript (pre-crRNA) processing endoribonuclease-related (From Topology)	T: CRISPR transcript (pre-crRNA) processing endoribonuclease-related	F: Cas_Csy4_C	ECOD (1.6)
A [auth C]	Cas_Csy4_N	e7jzxC1	A: a+b two layers	X: Alpha-beta plaits	H: CRISPR transcript (pre-crRNA) processing endoribonuclease-related (From Topology)	T: CRISPR transcript (pre-crRNA) processing endoribonuclease-related	F: Cas_Csy4_N	ECOD (1.6)
B	F_UNCLASSIFIED	e7jzxB1	A: a+b two layers	X: Alpha-beta plaits	H: CRISPR system Cas5 homologs (From Topology)	T: CRISPR system Cas5 homologs	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth E]	F_UNCLASSIFIED	e7jzxE1	A: a+b two layers	X: Alpha-beta plaits	H: Cas7-related	T: CRISPR-associated protein Cas7f/Csy3	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e7jzxD1	A: a+b two layers	X: Alpha-beta plaits	H: Cas7-related	T: CRISPR-associated protein Cas7f/Csy3	F: F_UNCLASSIFIED	ECOD (1.6)
E [auth F]	F_UNCLASSIFIED	e7jzxF1	A: a+b two layers	X: Alpha-beta plaits	H: Cas7-related	T: CRISPR-associated protein Cas7f/Csy3	F: F_UNCLASSIFIED	ECOD (1.6)
F [auth G]	F_UNCLASSIFIED	e7jzxG1	A: a+b two layers	X: Alpha-beta plaits	H: Cas7-related	T: CRISPR-associated protein Cas7f/Csy3	F: F_UNCLASSIFIED	ECOD (1.6)
G [auth H]	F_UNCLASSIFIED	e7jzxH1	A: a+b two layers	X: Alpha-beta plaits	H: Cas7-related	T: CRISPR-associated protein Cas7f/Csy3	F: F_UNCLASSIFIED	ECOD (1.6)
H [auth I]	F_UNCLASSIFIED	e7jzxI1	A: a+b two layers	X: Alpha-beta plaits	H: Cas7-related	T: CRISPR-associated protein Cas7f/Csy3	F: F_UNCLASSIFIED	ECOD (1.6)
I [auth A]	F_UNCLASSIFIED	e7jzxA1	A: a+b complex topology	X: Cas8-like	H: Cas8f/Csy1 (From Topology)	T: Cas8f/Csy1	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth C]	3.30.70.2540	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	CRISPR-associated endoribonuclease Cas6/Csy4	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C]	PF09618	CRISPR-associated protein (Cas_Csy4) (Cas_Csy4)	CRISPR-associated protein (Cas_Csy4)	-	Family
B	PF09614	CRISPR-associated protein (Cas_Csy2) (Cas_Csy2)	CRISPR-associated protein (Cas_Csy2)	-	Family
C [auth E], D, E [auth F], F [auth G], G [auth H], C [auth E], D, E [auth F], F [auth G], G [auth H], H [auth I]	PF09615	CRISPR-associated protein (Cas_Csy3) (Cas_Csy3)	CRISPR-associated protein (Cas_Csy3)	-	Family
I [auth A]	PF09611	CRISPR-associated protein (Cas_Csy1) (Cas_Csy1)	CRISPR-associated protein (Cas_Csy1)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C]	CRISPR-associated endonuclease Cas6/Csy4	endonuclease activity nuclease activity hydrolase activity, acting on ester bonds hydrolase activity catalytic activity RNA binding binding nucleic acid binding	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to stress response to external biotic stimulus response to virus maintenance of CRISPR repeat elements chromosome organization primary metabolic process biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to stress response to external biotic stimulus response to virus maintenance of CRISPR repeat elements chromosome organization primary metabolic process DNA metabolic process maintenance of DNA repeat elements nucleic acid metabolic process cellular component organization nucleobase-containing compound metabolic process organelle organization cellular process metabolic process cellular component organization or biogenesis macromolecule metabolic process	-
B	Type I-F CRISPR-associated protein Csy2	-	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to stress response to external biotic stimulus response to virus	-
C [auth E], D, E [auth F], F [auth G], G [auth H], C [auth E], D, E [auth F], F [auth G], G [auth H], H [auth I]	CRISPR type I-F/YPEST-associated protein Csy3	-	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to stress response to external biotic stimulus response to virus	-
I [auth A]	CRISPR-associated protein Csy1	-	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to stress response to external biotic stimulus response to virus	-
J [auth M]	RNA (61-MER)	-	-	-
K [auth J]	AcrF7	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C]	IPR013396	CRISPR-associated endoribonuclease Cas6/Csy4, subtype I-F/YPEST	Family
A [auth C]	IPR042564	CRISPR-associated endoribonuclease Cas6/Csy4, subtype I-F/YPEST superfamily	Homologous Superfamily
B	IPR013398	Type I-F CRISPR-associated protein Csy2	Family
C [auth E], D, E [auth F], F [auth G], G [auth H], C [auth E], D, E [auth F], F [auth G], G [auth H], H [auth I]	IPR013399	Type I-F CRISPR-associated protein Csy3	Family
I [auth A]	IPR013397	Type I-F CRISPR-associated protein Csy1	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.