Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyProtein kinase-like (PK-like) 8035244 3000066 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyProtein kinase-like (PK-like) 8035244 3000066 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyProtein kinase-like (PK-like) 8042320 3000066 SCOP2B (2022-06-29)
D [auth X]SCOP2B Superfamily14-3-3 protein 8093918 3001329 SCOP2B (2022-06-29)
E [auth Y]SCOP2B Superfamily14-3-3 protein 8093918 3001329 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APkinase_Tyre6q0tA1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
BPkinase_Tyre6q0tB1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
CPkinase_Tyre6q0tC1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
D [auth X]14-3-3e6q0tX1 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: 14-3-3ECOD (1.6)
E [auth Y]14-3-3e6q0tY1 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: 14-3-3ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF07714Protein tyrosine and serine/threonine kinase (PK_Tyr_Ser-Thr)Protein tyrosine and serine/threonine kinaseProtein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosph ...Domain
PF00069Protein kinase domain (Pkinase)Protein kinase domain- Domain
D [auth X],
E [auth Y]
PF0024414-3-3 protein (14-3-3)14-3-3 protein- Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Serine/threonine-protein kinase B-raf
Dual specificity mitogen-activated protein kinase kinase 1
D [auth X],
E [auth Y]
14-3-3 protein zeta-

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, B
PharosP15056
PharosQ02750

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
A, B
SEP Parent Component: SER

RESIDAA0037

PSI-MOD :  O-phospho-L-serine MOD:00046