SER

SERINE

Created:	1999-07-08
Last modified:	2024-09-27

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110 entries where SER is found as a standalone ligand50 entries where SER is covalently linked to polymer or other heterogen groups 222,921 entries where SER is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	1
Bond Count	13
Aromatic Bond Count	0

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Chemical Component Summary
Name	SERINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-3-hydroxy-propanoic acid
Formula	C₃ H₇ N O₃
Molecular Weight	105.093
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CO
SMILES	CACTVS	3.341	N[CH](CO)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(C(C(=O)O)N)O
Canonical SMILES	CACTVS	3.341	N[C@@H](CO)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C([C@@H](C(=O)O)N)O
InChI	InChI	1.03	InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey	InChI	1.03	MTCFGRXMJLQNBG-REOHCLBHSA-N

Drug Info: DrugBank

DrugBank ID	DB00133
Name	Serine
Groups	investigational nutraceutical
Description	A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.
Synonyms	L-Serine Serina beta-Hydroxyalanine Ser (S)-2-Amino-3-hydroxypropanoic acid Serine Serinum (S)-Serine alpha-Amino-beta-hydroxypropionic acid
Brand Names	2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose FreAmine III ProSol Travasol Aminosyn 8.5% Injection With Electrolytes 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn II 7% With 10% Dextrose Aminosyn 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Primene Aminosyn II 8.5% Injection Periolimel 2.5% E 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn-PF 7% Aminosyn II In Dextrose Injection Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Aminosyn II and Dextrose Hepatasol Aminosyn II 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Plenamine 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Olimel 4.4% Smofkabiven Olimel 7.6% E Essepna Clinisol Synthamin Olimel 5.7% E 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Aminosyn II 10% With Electrolytes Aminosyn Sulfite Free Aminosyn II in Dextrose Aminosyn II with Electrolytes in Dextrose with Calcium Aminosyn-PF 10% 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn 3.5% M FreAmine HBC Smofkabiven Peripheral Aminosyn II 8.5% With 50% Dextrose ProcalAmine Vamin 18 Electrolyte-free Nutrineal Pd4 Vamin N Olimel 4.4% E Aminosyn II 7% M In 10% Dextrose(dual Chamber) 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Smofkabiven Extra Nitrogen Electrolyte Free Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Premasol - sulfite-free (Amino Acid) Olimel 5.7% 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Aminosyn II 7% Injection Aminosyn 5% Smofkabiven Electrolyte Free 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Primene 10%-liq IV Primene 10% Renamin (amino Acids) Injection 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Aminosyn 7% Perikabiven Aminosyn-PF 8.5% Freamine III 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Aminosyn II with Electrolytes Aminosyn 10% W Electrolytes Aminosyn 8.5% Clinimix E Aminosyn HF Smofkabiven Extra Nitrogen Olimel 3.3% E HepatAmine TrophAmine Olimel 7.6% 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. RenAmin Aminosyn II 7% With 50% Dextrose Clinimix 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Kabiven 20% Prosol Novamine Aminosyn II 5% Inj
Indication	Used as a natural moisturizing agent in some cosmetics and skin care products.
Categories	Amino Acids Amino Acids, Neutral Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	56-45-1

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Cystathionine beta-synthase	MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPS...	unknown
L-serine dehydratase/L-threonine deaminase	MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCK...	unknown
Serine racemase	MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQ...	unknown
Serine palmitoyltransferase 2	MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQ...	unknown
Serine palmitoyltransferase 1	MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERS...	unknown
Serine--tRNA ligase, cytoplasmic	MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRA...	unknown
Alanine--glyoxylate aminotransferase	MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMS...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	5951, 6857581
ChEMBL	CHEMBL11298
ChEBI	CHEBI:17115, CHEBI:33384
CCDC/CSD	ZIXBOA, AYACUZ, NELRAX, RIWKUD01, DLSERN34, YIGLUX, DLSERN12, XENXUL02, TIXGOW, MIFQUN05, MIFQUN04, MIFQUN06, EYOQOY, MIFQUN07, MIFQUN08, MIFQUN03, VOKHEJ, MIFQUN02, JEJVEA, MIFQUN10, MIFQUN, XATVUK, REZPET, AJODUA, MIFQUN09, JEJVAW, REZPAP, BUTBOJ, GUQBUR, AJODOU, KERMID, XENXUL01, XENXUL, TACPAS, PAZCUO01