SER

SERINE

Created:	1999-07-08
Last modified:	2024-09-27

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111 entries where SER is found as a standalone ligand51 entries where SER is covalently linked to polymer or other heterogen groups 224,171 entries where SER is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	1
Bond Count	13
Aromatic Bond Count	0

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Chemical Component Summary
Name	SERINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-3-hydroxy-propanoic acid
Formula	C₃ H₇ N O₃
Molecular Weight	105.093
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CO
SMILES	CACTVS	3.341	N[CH](CO)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(C(C(=O)O)N)O
Canonical SMILES	CACTVS	3.341	N[C@@H](CO)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C([C@@H](C(=O)O)N)O
InChI	InChI	1.03	InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey	InChI	1.03	MTCFGRXMJLQNBG-REOHCLBHSA-N

Drug Info: DrugBank

DrugBank ID	DB00133
Name	Serine
Groups	nutraceutical investigational
Description	A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.
Synonyms	(S)-Serine L-Serine Serinum alpha-Amino-beta-hydroxypropionic acid Ser (S)-2-Amino-3-hydroxypropanoic acid Serine Serina beta-Hydroxyalanine
Brand Names	Smofkabiven Aminosyn II In Dextrose Injection Aminosyn II with Electrolytes in Dextrose with Calcium Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Synthamin Perikabiven ProSol Vamin N Aminosyn II in Dextrose Vamin 18 Electrolyte-free Smofkabiven Extra Nitrogen Aminosyn 3.5% M Aminosyn II and Dextrose Primene 10% Clinimix 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Olimel 4.4% Smofkabiven Extra Nitrogen Electrolyte Free Hepatasol Aminosyn II 8.5% Injection Aminosyn II 8.5% With 50% Dextrose Aminosyn II 10% With Electrolytes Olimel 3.3% E Aminosyn Sulfite Free Smofkabiven Electrolyte Free Aminosyn 8.5% Aminosyn II 7% With 10% Dextrose 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Olimel 5.7% Aminosyn 8.5% Injection With Electrolytes 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Aminosyn II 7% M In 10% Dextrose(dual Chamber) FreAmine HBC Aminosyn-PF 7% Smofkabiven Peripheral Essepna 8.5% Freamine III Aminosyn II 7% With 50% Dextrose Olimel 4.4% E Clinimix E HepatAmine Olimel 5.7% E Plenamine Aminosyn-PF 10% 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Aminosyn Travasol Renamin (amino Acids) Injection Aminosyn 7% 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Clinisol Aminosyn 5% FreAmine III Aminosyn II 7% Injection 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Olimel 7.6% Aminosyn-PF Aminosyn HF Primene 10%-liq IV Olimel 7.6% E Aminosyn II 5% Inj Premasol - sulfite-free (Amino Acid) 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Kabiven RenAmin 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Nutrineal Pd4 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose 20% Prosol Aminosyn II with Electrolytes 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn II 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Novamine Primene Aminosyn 10% W Electrolytes Periolimel 2.5% E TrophAmine ProcalAmine 4.25%trav. Amino Acid InJ.W.O.elect.5%dext.
Indication	Used as a natural moisturizing agent in some cosmetics and skin care products.
Categories	Amino Acids Amino Acids, Neutral Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	56-45-1

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Cystathionine beta-synthase	MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPS...	unknown
L-serine dehydratase/L-threonine deaminase	MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCK...	unknown
Serine racemase	MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQ...	unknown
Serine palmitoyltransferase 2	MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQ...	unknown
Serine palmitoyltransferase 1	MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERS...	unknown
Serine--tRNA ligase, cytoplasmic	MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRA...	unknown
Alanine--glyoxylate aminotransferase	MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMS...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	5951, 6857581
ChEMBL	CHEMBL11298
ChEBI	CHEBI:33384, CHEBI:17115
CCDC/CSD	ZIXBOA, AYACUZ, NELRAX, RIWKUD01, DLSERN34, YIGLUX, DLSERN12, XENXUL02, TIXGOW, MIFQUN05, MIFQUN04, MIFQUN06, EYOQOY, MIFQUN07, MIFQUN08, MIFQUN03, VOKHEJ, MIFQUN02, JEJVEA, MIFQUN10, MIFQUN, XATVUK, REZPET, AJODUA, MIFQUN09, JEJVAW, REZPAP, BUTBOJ, GUQBUR, AJODOU, KERMID, XENXUL01, XENXUL, TACPAS, PAZCUO01