6OUG

Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor, TM + cytosolic helix construct

External Resource: Annotation

Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UNK_F_TYPE	e6ougA1	A: few secondary structure elements	X: Influenza A M2 transmembrane domain (From Topology)	H: Influenza A M2 transmembrane domain (From Topology)	T: Influenza A M2 transmembrane domain	F: UNK_F_TYPE	ECOD (1.6)
B	UNK_F_TYPE	e6ougB1	A: few secondary structure elements	X: Influenza A M2 transmembrane domain (From Topology)	H: Influenza A M2 transmembrane domain (From Topology)	T: Influenza A M2 transmembrane domain	F: UNK_F_TYPE	ECOD (1.6)
C	UNK_F_TYPE	e6ougC1	A: few secondary structure elements	X: Influenza A M2 transmembrane domain (From Topology)	H: Influenza A M2 transmembrane domain (From Topology)	T: Influenza A M2 transmembrane domain	F: UNK_F_TYPE	ECOD (1.6)
E	UNK_F_TYPE	e6ougE1	A: few secondary structure elements	X: Influenza A M2 transmembrane domain (From Topology)	H: Influenza A M2 transmembrane domain (From Topology)	T: Influenza A M2 transmembrane domain	F: UNK_F_TYPE	ECOD (1.6)
H	UNK_F_TYPE	e6ougH1	A: few secondary structure elements	X: Influenza A M2 transmembrane domain (From Topology)	H: Influenza A M2 transmembrane domain (From Topology)	T: Influenza A M2 transmembrane domain	F: UNK_F_TYPE	ECOD (1.6)
D	UNK_F_TYPE	e6ougD1	A: few secondary structure elements	X: Influenza A M2 transmembrane domain (From Topology)	H: Influenza A M2 transmembrane domain (From Topology)	T: Influenza A M2 transmembrane domain	F: UNK_F_TYPE	ECOD (1.6)
F	UNK_F_TYPE	e6ougF1	A: few secondary structure elements	X: Influenza A M2 transmembrane domain (From Topology)	H: Influenza A M2 transmembrane domain (From Topology)	T: Influenza A M2 transmembrane domain	F: UNK_F_TYPE	ECOD (1.6)
G	UNK_F_TYPE	e6ougG1	A: few secondary structure elements	X: Influenza A M2 transmembrane domain (From Topology)	H: Influenza A M2 transmembrane domain (From Topology)	T: Influenza A M2 transmembrane domain	F: UNK_F_TYPE	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Matrix protein 2	passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis symbiont-mediated disruption of host anatomical structure biological process involved in interspecies interaction between organisms viral life cycle symbiont-mediated disruption of host cellular anatomical structure biological process involved in interaction with host biological process involved in symbiotic interaction cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis symbiont-mediated disruption of host anatomical structure biological process involved in interspecies interaction between organisms viral life cycle symbiont-mediated disruption of host cellular anatomical structure biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated perturbation of host membrane symbiont genome entry into host cell via pore formation in plasma membrane symbiont entry into host cell viral process symbiont entry into host disruption of anatomical structure in another organism suppression by virus of host autophagy symbiont-mediated perturbation of host process modulation by virus of host autophagy modulation by virus of host process modulation of process of another organism modulation by virus of host cellular process	cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane virion component virion membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR002089	Influenza virus matrix protein 2	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E A, B, C, D, E, F, G, H	OPM	Transmembrane	Bitopic proteins	Viral channel proteins	Influenza virus matrix protein 2

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G, H	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D, E A, B, C, D, E, F, G, H	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Other Ion Channels	M2 proton channel (AM2) V27A mutant bound to spiroadamantyl amine inhibitor

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.