6N48

Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric modulator

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	G protein-coupled receptor-like	8091150	3000473	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	7tm_1_3	e6n48A2	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_3	ECOD (1.6)
A	Phage_lysozyme_2	e6n48A1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Phage_lysozyme_2	ECOD (1.6)
B	V-set_1	e6n48B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_1	ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
B	Antibody Fab Fragment	VH	Vicugna pacos (alpaca)	IGHV3S5301, IGHJ401	V-DOMAIN VH	IG	VH	IMGT (202448-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B	Heavy Chain	IGHV1	-	endolysin,beta-2 adrenergic receptor,beta-2 adrenergicreceptor chimera	SAbDab (2024-12-06)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Endolysin,Beta-2 adrenergic receptor,Beta-2 adrenergic receptor chimera	amide binding amyloid-beta binding binding peptide binding protein binding enzyme binding adenylate cyclase binding G protein-coupled amine receptor activity molecular transducer activity beta2-adrenergic receptor activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity beta-adrenergic receptor activity amide binding amyloid-beta binding binding peptide binding protein binding enzyme binding adenylate cyclase binding G protein-coupled amine receptor activity molecular transducer activity beta2-adrenergic receptor activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity beta-adrenergic receptor activity adrenergic receptor activity potassium channel regulator activity channel regulator activity ion channel regulator activity molecular function regulator activity transporter regulator activity identical protein binding protein homodimerization activity protein dimerization activity cation binding ion binding catecholamine binding organic cyclic compound binding norepinephrine binding small molecule binding	multicellular organismal process response to nutrient levels response to stimulus homeostatic process adaptive thermogenesis multicellular organismal-level homeostasis response to dietary excess diet induced thermogenesis metabolic process cellular process energy homeostasis response to stress response to abiotic stimulus response to cold multicellular organismal process response to nutrient levels response to stimulus homeostatic process adaptive thermogenesis multicellular organismal-level homeostasis response to dietary excess diet induced thermogenesis metabolic process cellular process energy homeostasis response to stress response to abiotic stimulus response to cold response to temperature stimulus regulation of developmental process positive regulation of biological process regulation of biomineral tissue development regulation of bone mineralization positive regulation of ossification positive regulation of developmental process multicellular organism development positive regulation of biomineral tissue development ossification anatomical structure development biomineral tissue development regulation of multicellular organismal process developmental process regulation of multicellular organismal development regulation of biological process bone mineralization animal organ development biological regulation tissue development positive regulation of bone mineralization positive regulation of multicellular organismal process regulation of ossification regulation of multicellular organism growth regulation of growth regulation of developmental growth negative regulation of multicellular organism growth developmental growth negative regulation of developmental process growth negative regulation of biological process multicellular organism growth negative regulation of developmental growth negative regulation of growth negative regulation of multicellular organismal process cellular response to stimulus adenylate cyclase-activating adrenergic receptor signaling pathway regulation of cellular process signaling adenylate cyclase-activating G protein-coupled receptor signaling pathway cell communication adrenergic receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction fat cell differentiation cellular developmental process brown fat cell differentiation cell differentiation system process regulation of system process muscle contraction muscle system process regulation of muscle system process negative regulation of muscle contraction smooth muscle contraction regulation of smooth muscle contraction regulation of muscle contraction negative regulation of smooth muscle contraction positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process tissue remodeling bone remodeling anatomical structure homeostasis tissue homeostasis bone resorption positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process cell surface receptor protein tyrosine kinase signaling pathway cellular component biogenesis cellular component assembly regulation of phosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process protein modification process positive regulation of protein phosphorylation activation of transmembrane receptor protein tyrosine kinase activity protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process regulation of molecular function positive regulation of kinase activity regulation of kinase activity activation of protein kinase activity macromolecule modification regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process cellular component organization positive regulation of molecular function positive regulation of protein modification process protein-containing complex assembly cellular component organization or biogenesis protein metabolic process positive regulation of protein kinase activity enzyme-linked receptor protein signaling pathway positive regulation of transferase activity cell surface receptor signaling pathway protein-containing complex organization positive regulation of catalytic activity regulation of protein kinase activity regulation of phosphorylation localization import into cell transport receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport cellular localization endosome to lysosome transport intracellular transport lysosomal transport establishment of localization in cell vacuolar transport positive regulation of organelle organization catabolic process regulation of cellular component organization positive regulation of cellular component organization regulation of autophagosome maturation macroautophagy autophagy protein-containing complex disassembly regulation of autophagy regulation of protein-containing complex disassembly autophagosome maturation positive regulation of macroautophagy process utilizing autophagic mechanism positive regulation of protein-containing complex disassembly cellular component disassembly positive regulation of autophagy regulation of catabolic process positive regulation of autophagosome maturation regulation of organelle organization positive regulation of catabolic process organelle organization regulation of macroautophagy lipophagy positive regulation of lipophagy regulation of lipophagy response to psychosocial stress regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication positive regulation of signaling ligand-gated ion channel signaling pathway ionotropic glutamate receptor signaling pathway glutamate receptor signaling pathway AMPA selective glutamate receptor signaling pathway regulation of tube diameter regulation of systemic arterial blood pressure mediated by a chemical signal regulation of blood pressure regulation of tube size norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure negative regulation of blood pressure regulation of systemic arterial blood pressure by norepinephrine-epinephrine regulation of systemic arterial blood pressure circulatory system process negative regulation of systemic arterial blood pressure vascular process in circulatory system regulation of biological quality blood vessel diameter maintenance vasodilation blood circulation regulation of anatomical structure size negative regulation of signaling negative regulation of response to stimulus negative regulation of signal transduction negative regulation of G protein-coupled receptor signaling pathway negative regulation of cell communication negative regulation of cellular process regulation of G protein-coupled receptor signaling pathway positive regulation of cAMP/PKA signal transduction cAMP/PKA signal transduction regulation of cAMP/PKA signal transduction cellular response to nitrogen compound response to oxygen-containing compound response to nitrogen compound cellular response to amyloid-beta cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical response to amyloid-beta regulation of localization regulation of transport regulation of monoatomic ion transport regulation of sodium ion transport metal ion transport monoatomic ion transport monoatomic cation transport regulation of metal ion transport sodium ion transport heat generation regulation of postsynaptic membrane potential modulation of chemical synaptic transmission positive regulation of excitatory postsynaptic potential chemical synaptic transmission, postsynaptic synaptic signaling modulation of excitatory postsynaptic potential mini excitatory postsynaptic potential trans-synaptic signaling nervous system process cell-cell signaling chemical synaptic transmission regulation of nervous system process regulation of mini excitatory postsynaptic potential positive regulation of mini excitatory postsynaptic potential regulation of trans-synaptic signaling anterograde trans-synaptic signaling excitatory postsynaptic potential regulation of membrane potential	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure dense core granule intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure dense core granule intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle neuronal dense core vesicle bounding membrane of organelle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane clathrin-coated endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane organelle membrane protein-containing complex receptor complex Golgi apparatus endosome membrane endosome cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane lytic vacuole vacuole lysosome early endosome nucleus
B	Camelid Antibody Fragment	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000332	Beta 2 adrenoceptor	Family
A	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
A	IPR002233	Adrenoceptor family	Family
A	IPR017452	GPCR, rhodopsin-like, 7TM	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P07550	asthma cardiomyopathy dilated cardiomyopathy Ventricular Dysfunction, Left prostate cancer HIV infectious disease nervous system disorder AIDS dementia complex chronic obstructive pulmonary disease lung disease potassium deficiency disease obesity disorder bipolar disorder ovarian cancer essential tremor asthma cardiomyopathy dilated cardiomyopathy Ventricular Dysfunction, Left prostate cancer HIV infectious disease nervous system disorder AIDS dementia complex chronic obstructive pulmonary disease lung disease potassium deficiency disease obesity disorder bipolar disorder ovarian cancer essential tremor familial hyperlipidemia breast fibroadenoma peripheral nervous system disease lung adenocarcinoma glaucoma cardiac arrest hereditary diffuse gastric adenocarcinoma pulmonary emphysema hypertensive disorder inherited susceptibility to asthma atrial fibrillation ocular hypertension dilated cardiomyopathy 1A breast cancer Parkinson disease fibromyalgia vasomotor rhinitis bronchiectasis peripheral neuropathy gastric cancer viral encephalitis lung cancer malignant colon neoplasm seasonal allergic rhinitis hypertrophic cardiomyopathy allergic rhinitis myocardial ischemia non-small cell lung carcinoma intrinsic asthma atrioventricular block open-angle glaucoma dry eye syndrome B-cell chronic lymphocytic leukemia osteosarcoma breast carcinoma bronchitis gastric neoplasm hemangioma malignant ependymoma psoriasis medulloblastoma rhinitis hyperlipidemia allergic asthma monogenic obesity anaphylaxis common cold coronary artery disease atopic conjunctivitis invasive ductal breast carcinoma autism ductal breast carcinoma in situ

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class A	β₂ adrenergic receptor with a bound positive allosteric modulator

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.