6EBM | pdb_00006ebm

The voltage-activated Kv1.2-2.1 paddle chimera channel in lipid nanodiscs, transmembrane domain of subunit alpha

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth D], C [auth F], D [auth H]	PF07885	Ion channel (Ion_trans_2)	Ion channel	-	Family
A [auth B], B [auth D], C [auth F], D [auth H]	PF00520	Ion transport protein (Ion_trans)	Ion transport protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth D], C [auth F], D [auth H]	Potassium voltage-gated channel subfamily A member 2,Potassium voltage-gated channel subfamily B member 2 chimera	cytoskeletal protein binding protein binding binding kinesin binding passive transmembrane transporter activity gated channel activity voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential monoatomic ion channel activity channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity cytoskeletal protein binding protein binding binding kinesin binding passive transmembrane transporter activity gated channel activity voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential monoatomic ion channel activity channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity potassium ion transmembrane transporter activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity voltage-gated potassium channel activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity metal ion transmembrane transporter activity delayed rectifier potassium channel activity voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential outward rectifier potassium channel activity transmembrane transporter binding protein heterodimerization activity protein dimerization activity	developmental process corpus callosum development multicellular organismal process head development forebrain development animal organ development brain development nervous system development multicellular organism development central nervous system development anatomical structure development telencephalon development system development nerve development developmental process corpus callosum development multicellular organismal process head development forebrain development animal organ development brain development nervous system development multicellular organism development central nervous system development anatomical structure development telencephalon development system development nerve development cranial nerve development optic nerve development transport monoatomic ion transmembrane transport potassium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport potassium ion transport cellular process monoatomic cation transport biological regulation action potential regulation of biological quality regulation of membrane potential monoamine transport regulation of localization nitrogen compound transport regulation of cellular process regulation of catecholamine secretion signaling organic hydroxy compound transport dopamine transport cell communication secretion by cell regulation of secretion by cell catecholamine transport signal release regulation of biological process secretion regulation of transport export from cell cell-cell signaling dopamine secretion regulation of secretion catecholamine secretion amine transport regulation of amine transport regulation of dopamine secretion cranial nerve morphogenesis anatomical structure morphogenesis cranial nerve structural organization anatomical structure arrangement optic nerve morphogenesis optic nerve structural organization export across plasma membrane potassium ion export across plasma membrane system process nervous system process transmission of nerve impulse neuronal action potential circadian sleep/wake cycle, sleep rhythmic process circadian sleep/wake cycle rhythmic behavior circadian rhythm regulation of circadian sleep/wake cycle regulation of circadian sleep/wake cycle, non-REM sleep regulation of circadian rhythm circadian sleep/wake cycle, non-REM sleep behavior regulation of behavior circadian behavior sleep regulation of multicellular organismal process regulation of circadian sleep/wake cycle, sleep circadian sleep/wake cycle process pallium development cerebral cortex development sensory perception sensory perception of pain cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis protein localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane axon main axon juxtaparanode region of axon neuron projection somatodendritic compartment cell body perikaryon neuronal cell body cell-cell junction anchoring junction paranodal junction presynapse presynaptic membrane dendrite dendritic tree axon initial segment glutamatergic synapse voltage-gated potassium channel complex protein-containing complex plasma membrane protein complex potassium channel complex membrane protein complex cation channel complex transporter complex transmembrane transporter complex monoatomic ion channel complex membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane leading edge membrane lamellipodium membrane cell projection membrane axon terminus distal axon calyx of Held neuron projection terminus endosome intracellular vesicle cytoplasmic vesicle vesicle neuronal cell body membrane cell body membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth D], C [auth F], D [auth H]	IPR003972	Potassium channel, voltage dependent, Kv1	Family
A [auth B], B [auth D], C [auth F], D [auth H]	IPR028325	Voltage-gated potassium channel	Family
A [auth B], B [auth D], C [auth F], D [auth H]	IPR000210	BTB/POZ domain	Domain
A [auth B], B [auth D], C [auth F], D [auth H]	IPR003968	Potassium channel, voltage dependent, Kv	Family
A [auth B], B [auth D], C [auth F], D [auth H]	IPR005821	Ion transport domain	Domain
A [auth B], B [auth D], C [auth F], D [auth H]	IPR003131	Potassium channel tetramerisation-type BTB domain	Domain
A [auth B], B [auth D], C [auth F], D [auth H]	IPR004049	Potassium channel, voltage dependent, Kv1.2	Family
A [auth B], B [auth D], C [auth F], D [auth H]	IPR011333	SKP1/BTB/POZ domain superfamily	Homologous Superfamily
A [auth B], B [auth D], C [auth F], D [auth H]	IPR027359	Voltage-dependent channel domain superfamily	Homologous Superfamily
A [auth B], B [auth D], C [auth F], D [auth H]	IPR005821	Ion transport domain	Domain
A [auth B], B [auth D], C [auth F], D [auth H]	IPR005826	Potassium channel, voltage dependent, Kv2.2	Family
A [auth B], B [auth D], C [auth F], D [auth H]	IPR003973	Potassium channel, voltage dependent, Kv2	Family
A [auth B], B [auth D], C [auth F], D [auth H]	IPR028325	Voltage-gated potassium channel	Family
A [auth B], B [auth D], C [auth F], D [auth H]	IPR000210	BTB/POZ domain	Domain
A [auth B], B [auth D], C [auth F], D [auth H]	IPR003968	Potassium channel, voltage dependent, Kv	Family
A [auth B], B [auth D], C [auth F], D [auth H]	IPR003131	Potassium channel tetramerisation-type BTB domain	Domain
A [auth B], B [auth D], C [auth F], D [auth H]	IPR011333	SKP1/BTB/POZ domain superfamily	Homologous Superfamily
A [auth B], B [auth D], C [auth F], D [auth H]	IPR027359	Voltage-dependent channel domain superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth B], B [auth D], C [auth F], D [auth H]	OPM	Transmembrane	Alpha-helical polytopic	Ion channel (VIC) superfamily	KvAP voltage-regulated K channels

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth B], B [auth D], C [auth F], D [auth H]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A [auth B], B [auth D], C [auth F], D [auth H]	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A [auth B], B [auth D], C [auth F], D [auth H]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Potassium, Sodium, & Proton Ion-Selective	Kv1.2/Kv2.1 voltage-gated potassium channel chimera in lipid nanodiscs

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.