5U7O
Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-626529 in Complex with Human Antibodies PGT122 and 35O22 at 3.8 Angstrom
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A [auth B] | SCOP2 Family | Virus ectodomain | 8085617 | 4003841 | SCOP2 (2022-06-29) |
A [auth B] | SCOP2 Superfamily | Virus ectodomain | 8085618 | 3001628 | SCOP2 (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth B] | GP41_1st | e5u7oB1 | A: a+b duplicates or obligate multimers | X: MPER trimer (From Topology) | H: MPER trimer (From Topology) | T: MPER trimer | F: GP41_1st | ECOD (1.6) |
B [auth D] | V-set_8 | e5u7oD2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
B [auth D] | C1-set_1 | e5u7oD1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_1 | ECOD (1.6) |
C [auth E] | C1-set | e5u7oE1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set | ECOD (1.6) |
C [auth E] | V-set_3 | e5u7oE2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_3 | ECOD (1.6) |
D [auth G] | GP120_2nd | e5u7oG3 | A: beta barrels | X: V1/V2 domain in HIV gp120 (From Topology) | H: V1/V2 domain in HIV gp120 (From Topology) | T: V1/V2 domain in HIV gp120 | F: GP120_2nd | ECOD (1.6) |
D [auth G] | GP120_3rd | e5u7oG2 | A: a+b two layers | X: Ribosomal protein L31e-like | H: Ribosomal protein L31e/gp120 outer domain (From Topology) | T: Ribosomal protein L31e/gp120 outer domain | F: GP120_3rd | ECOD (1.6) |
D [auth G] | GP120_1st | e5u7oG1 | A: a+b two layers | X: gp120 inner domain (From Topology) | H: gp120 inner domain (From Topology) | T: gp120 inner domain | F: GP120_1st | ECOD (1.6) |
E [auth H] | V-set_8 | e5u7oH2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
E [auth H] | C1-set_1 | e5u7oH1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_1 | ECOD (1.6) |
F [auth L] | C1-set | e5u7oL2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set | ECOD (1.6) |
F [auth L] | V-set_3 | e5u7oL1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_3 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B [auth D] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
C [auth E] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
E [auth H] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
F [auth L] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
B [auth D] | Fab 35O22 | VH-CH1 | Homo sapiens (human) | IGHV1-18*01, IGHV1-18*04, IGHJ1*01, IGHJ4*01, IGHJ5*02, IGHJ4*02, IGHJ4*03, IGHG1*03, IGHG1*08, IGHG1*06 | V-DOMAIN VH, C-DOMAIN CH1 | IG | FAB-GAMMA-1_LAMBDA | IMGT (202447-0) |
C [auth E] | Fab 35O22 | L-LAMBDA | Homo sapiens (human) | IGLV2-14*02, IGLV2-18*02, IGLV2-23*01, IGLV2-23*02, IGLV2-23*03, IGLJ1*01, IGLC2*01, IGLC2*02, IGLC3*04 | V-DOMAIN V-LAMBDA, C-DOMAIN C-LAMBDA | IG | FAB-GAMMA-1_LAMBDA | IMGT (202447-0) |
E [auth H] | Fab PGT122 | VH-CH1 | Homo sapiens (human) | IGHV4-59*02, IGHJ3*01, IGHG1*03, IGHG1*08, IGHG1*06 | V-DOMAIN VH, C-DOMAIN CH1 | IG | FAB-GAMMA-1_LAMBDA | IMGT (202447-0) |
F [auth L] | Fab PGT122 | L-LAMBDA | Homo sapiens (human) | IGLV3-21*01, IGLV3-21*02, IGLJ3*02, IGLC3*03 | V-DOMAIN V-LAMBDA, C-DOMAIN C-LAMBDA | IG | FAB-GAMMA-1_LAMBDA | IMGT (202447-0) |
SAbDab Antibody Annotation SAbDab Database Homepage
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
---|---|---|---|---|---|
E [auth H] | Heavy Chain | IGHV4 | - | envelope glycoprotein gp160 | SAbDab (2024-11-29) |
F [auth L] | Light Chain | IGLV3 | Lambda | envelope glycoprotein gp160 | SAbDab (2024-11-29) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth B] | PF00517 | Retroviral envelope protein (GP41) | Retroviral envelope protein | - | Family |
D [auth G] | PF00516 | Envelope glycoprotein GP120 (GP120) | Envelope glycoprotein GP120 | - | Family |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
A [auth B] | IPR000777 | Human immunodeficiency virus 1, envelope glycoprotein Gp120 | Domain |
A [auth B] | IPR036377 | Gp120 core superfamily | Homologous Superfamily |
A [auth B] | IPR000328 | Retroviral envelope protein GP41-like | Domain |
A [auth B] | IPR037527 | Envelope glycoprotein Gp160 | Family |
D [auth G] | IPR000777 | Human immunodeficiency virus 1, envelope glycoprotein Gp120 | Domain |
D [auth G] | IPR036377 | Gp120 core superfamily | Homologous Superfamily |
D [auth G] | IPR000328 | Retroviral envelope protein GP41-like | Domain |
D [auth G] | IPR037527 | Envelope glycoprotein Gp160 | Family |