5N16

First Bromodomain (BD1) from Candida albicans Bdf1 bound to a dibenzothiazepinone (compound 1)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5n16a1	All alpha proteins	Bromodomain-like	Bromodomain	automated matches	automated matches	Yeast (Candida albicans ) [TaxId: 5476 ],	SCOPe (2.08)
A	d5n16a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Yeast (Candida albicans ) [TaxId: 5476 ],	SCOPe (2.08)
B	d5n16b1	All alpha proteins	Bromodomain-like	Bromodomain	automated matches	automated matches	Yeast (Candida albicans ) [TaxId: 5476 ],	SCOPe (2.08)
B	d5n16b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Yeast (Candida albicans ) [TaxId: 5476 ],	SCOPe (2.08)
C	d5n16c1	All alpha proteins	Bromodomain-like	Bromodomain	automated matches	automated matches	Yeast (Candida albicans ) [TaxId: 5476 ],	SCOPe (2.08)
C	d5n16c2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Yeast (Candida albicans ) [TaxId: 5476 ],	SCOPe (2.08)
D	d5n16d1	All alpha proteins	Bromodomain-like	Bromodomain	automated matches	automated matches	Yeast (Candida albicans ) [TaxId: 5476 ],	SCOPe (2.08)
D	d5n16d2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Yeast (Candida albicans ) [TaxId: 5476 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Bromodomain	e5n16A1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)
B	Bromodomain	e5n16B1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)
C	Bromodomain	e5n16C1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)
D	Bromodomain	e5n16D1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.920.10	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)
D	1.20.920.10	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00439	Bromodomain (Bromodomain)	Bromodomain	Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Bromodomain-containing factor 1	protein binding binding histone binding	cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair sporulation resulting in formation of a cellular spore cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair sporulation resulting in formation of a cellular spore developmental process anatomical structure morphogenesis anatomical structure formation involved in morphogenesis anatomical structure development sporulation	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR050935	Bromodomain-containing chromatin reader	Family
A, B, C, D	IPR027353	NET domain	Domain
A, B, C, D	IPR038336	NET domain superfamily	Homologous Superfamily
A, B, C, D	IPR018359	Bromodomain, conserved site	Conserved Site
A, B, C, D	IPR001487	Bromodomain	Domain
A, B, C, D	IPR036427	Bromodomain-like superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.