Annotations: 5HY7

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	DDB1-like	8044840	4004169	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	WD40 repeat-like	8051195	3001694	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	WD40 repeat-like	8052532	3001694	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	WD40 repeat-like	8052533	3001694	SCOP2 (2022-06-29)
C [auth B]	SCOP2B Superfamily	WD40 repeat-like	8051195	3001694	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	WD40 repeat-like	8052532	3001694	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	WD40 repeat-like	8052532	3001694	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	WD40 repeat-like	8052533	3001694	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CPSF_A_N	e5hy7A1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: CPSF_A_N	ECOD (1.6)
A	MMS1_N_C	e5hy7A3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: MMS1_N_C	ECOD (1.6)
A	MMS1_N_N	e5hy7A4	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: MMS1_N_N	ECOD (1.6)
A	CPSF_A_C	e5hy7A2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: CPSF_A_C	ECOD (1.6)
C [auth B]	CPSF_A_N	e5hy7B1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: CPSF_A_N	ECOD (1.6)
C [auth B]	MMS1_N_C	e5hy7B3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: MMS1_N_C	ECOD (1.6)
C [auth B]	MMS1_N_N	e5hy7B4	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: MMS1_N_N	ECOD (1.6)
C [auth B]	CPSF_A_C	e5hy7B2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: CPSF_A_C	ECOD (1.6)
D [auth C]	SF3b10	e5hy7C1	A: alpha arrays	X: RDS3 complex subunit 10 (From Topology)	H: RDS3 complex subunit 10 (From Topology)	T: RDS3 complex subunit 10	F: SF3b10	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B]	PF10433	RSE1/DDB1/CPSF1 first beta-propeller (Beta-prop_RSE1_1st)	Mono-functional DNA-alkylating methyl methanesulfonate N-term	-	Repeat
A, C [auth B]	PF03178	CPSF A subunit region (CPSF_A)	CPSF A subunit region	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B]	Putative pre-mRNA splicing protein	RNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U2 snRNA binding cation binding ion binding metal ion binding small molecule binding	RNA splicing RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U2 snRNP membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U2 snRNP spliceosomal complex
B [auth D], D [auth C]	YSF3	-	RNA splicing RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome spliceosomal snRNP complex Sm-like protein family complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B]	IPR018846	RSE1/DDB1/CPSF1, first beta-propeller domain	Domain
A, C [auth B]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A, C [auth B]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A, C [auth B]	IPR004871	Cleavage/polyadenylation specificity factor, A subunit, C-terminal	Domain
A, C [auth B]	IPR050358	RSE1/DDB1/CFT1/CPSF1	Family
B [auth D], D [auth C]	IPR017089	Splicing factor 3B, subunit 5	Family
B [auth D], D [auth C]	IPR009846	Splicing factor 3B subunit 5/RDS3 complex subunit 10	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.