Annotations: 4ZPR

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	HLH	e4zprA3	A: alpha duplicates or obligate multimers	X: HLH-like	H: HLH, helix-loop-helix DNA-binding domain (From Topology)	T: HLH, helix-loop-helix DNA-binding domain	F: HLH	ECOD (1.6)
A	PAS_11	e4zprA1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PAS_11	ECOD (1.6)
A	PAS_11_1	e4zprA2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PAS_11_1	ECOD (1.6)
B	HLH	e4zprB3	A: alpha duplicates or obligate multimers	X: HLH-like	H: HLH, helix-loop-helix DNA-binding domain (From Topology)	T: HLH, helix-loop-helix DNA-binding domain	F: HLH	ECOD (1.6)
B	PAS_11	e4zprB2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PAS_11	ECOD (1.6)
B	PAS_11_1	e4zprB1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PAS_11_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00989	PAS fold (PAS)	PAS fold	The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs [4]. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (M ...	The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs [4]. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).	Domain
A	PF00010	Helix-loop-helix DNA-binding domain (HLH)	Helix-loop-helix DNA-binding domain	-	Domain
B	PF00989	PAS fold (PAS)	PAS fold	The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs [4]. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (M ...	The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs [4]. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).	Domain
B	PF08447	PAS fold (PAS_3)	PAS fold	The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs [4]. The PAS fold appears in archaea, eubacteria and eukarya.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Aryl hydrocarbon receptor nuclear translocator	DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein heterodimerization activity protein binding DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein heterodimerization activity protein binding protein dimerization activity transcription regulator activity DNA-binding transcription factor activity identical protein binding protein homodimerization activity nuclear receptor activity DNA-binding transcription factor activity, RNA polymerase II-specific molecular transducer activity ligand-activated transcription factor activity signaling receptor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding signaling receptor binding DNA-binding transcription factor binding aryl hydrocarbon receptor binding	developmental process cellular developmental process cell differentiation cellular process regulation of protein sumoylation regulation of cellular process regulation of protein modification process positive regulation of protein metabolic process peptidyl-lysine modification positive regulation of biological process positive regulation of post-translational protein modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process developmental process cellular developmental process cell differentiation cellular process regulation of protein sumoylation regulation of cellular process regulation of protein modification process positive regulation of protein metabolic process peptidyl-lysine modification positive regulation of biological process positive regulation of post-translational protein modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process regulation of protein modification by small protein conjugation or removal protein modification process positive regulation of cellular process positive regulation of protein modification by small protein conjugation or removal regulation of biological process regulation of post-translational protein modification regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process protein sumoylation macromolecule modification metabolic process macromolecule metabolic process positive regulation of protein sumoylation post-translational protein modification regulation of metabolic process protein modification by small protein conjugation protein modification by small protein conjugation or removal multicellular organismal process positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process regulation of cytokine production cytokine production regulation of multicellular organismal process regulation of vascular endothelial growth factor production regulation of biosynthetic process gene expression macromolecule biosynthetic process regulation of gene expression vascular endothelial growth factor production biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of vascular endothelial growth factor production regulation of macromolecule biosynthetic process positive regulation of cytokine production regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response defense response negative regulation of response to stimulus negative regulation of biological process response to external stimulus regulation of inflammatory response regulation of response to stimulus response to stress negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response positive regulation of hormone metabolic process regulation of hormone biosynthetic process regulation of hormone metabolic process regulation of hormone levels hormone metabolic process positive regulation of hormone biosynthetic process regulation of biological quality hormone biosynthetic process placenta development chordate embryonic development animal organ development embryo development in utero embryonic development multicellular organism development embryonic placenta development embryo development ending in birth or egg hatching anatomical structure development embryonic organ development response to chemical response to toxic substance cellular response to stimulus response to oxidative stress cellular response to chemical stimulus cellular response to stress cellular response to oxidative stress cellular response to chemical stress response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus positive regulation of DNA-templated transcription RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure organelle cytoplasm aryl hydrocarbon receptor complex receptor complex RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure organelle cytoplasm aryl hydrocarbon receptor complex receptor complex nuclear aryl hydrocarbon receptor complex intracellular protein-containing complex membrane-enclosed lumen intracellular organelle lumen nuclear body nucleoplasm organelle lumen nuclear lumen
B	Hypoxia-inducible factor 1-alpha	histone deacetylase binding protein binding binding enzyme binding sequence-specific DNA binding DNA binding organic cyclic compound binding nucleic acid binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific histone deacetylase binding protein binding binding enzyme binding sequence-specific DNA binding DNA binding organic cyclic compound binding nucleic acid binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity protein domain specific binding kinase binding protein kinase binding transcription factor binding transcription coregulator binding transcription coactivator binding E-box binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding DNA-binding transcription repressor activity p53 binding Hsp90 protein binding heat shock protein binding molecular function activator activity molecular function regulator activity transcription regulator activator activity protein heterodimerization activity protein dimerization activity	developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development response to stimulus response to activity response to muscle activity embryonic epithelial tube formation developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development response to stimulus response to activity response to muscle activity embryonic epithelial tube formation chordate embryonic development neural fold formation tube formation embryo development epithelial tube formation primary neural tube formation tube morphogenesis neural fold elevation formation embryo development ending in birth or egg hatching epithelial tube morphogenesis morphogenesis of an epithelial fold morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium nervous system development tissue morphogenesis anatomical structure morphogenesis neural tube formation anatomical structure formation involved in morphogenesis ossification bone mineralization biomineral tissue development cellular developmental process cell development epithelial cell differentiation intestinal epithelial cell maturation columnar/cuboidal epithelial cell development cell differentiation cell maturation digestive system development intestinal epithelial cell differentiation intestinal epithelial cell development developmental maturation digestive tract development epithelial cell development anatomical structure maturation cellular process columnar/cuboidal epithelial cell differentiation epithelial cell maturation columnar/cuboidal epithelial cell maturation apoptotic process cell death programmed cell death ribonucleotide catabolic process pyridine nucleotide catabolic process regulation of cellular process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process regulation of primary metabolic process regulation of ATP metabolic process nucleobase-containing compound metabolic process regulation of purine nucleotide catabolic process regulation of small molecule metabolic process glycolytic process regulation of nucleotide metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process regulation of nucleobase-containing compound metabolic process purine ribonucleotide catabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process pyruvate metabolic process regulation of biological process purine nucleoside diphosphate metabolic process primary metabolic process purine-containing compound catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process metabolic process regulation of nucleotide catabolic process regulation of phosphorus metabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process regulation of metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process catabolic process ATP metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process carbohydrate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process biological regulation ADP catabolic process carboxylic acid metabolic process regulation of catabolic process generation of precursor metabolites and energy regulation of glycolytic process purine-containing compound metabolic process ADP metabolic process organophosphate metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process response to metal ion response to iron ion response to chemical positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of miRNA transcription positive regulation of miRNA metabolic process positive regulation of macromolecule biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process positive regulation of metabolic process regulation of RNA metabolic process miRNA transcription positive regulation of biosynthetic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process miRNA metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of miRNA transcription cellular response to stimulus response to oxidative stress cellular response to chemical stimulus cellular response to stress response to stress cellular response to oxidative stress cellular response to chemical stress hemopoiesis embryonic hemopoiesis embryonic organ development mammary gland epithelial cell differentiation mammary gland development gland development epithelial cell differentiation involved in mammary gland alveolus development mammary gland lobule development mammary gland epithelium development mammary gland alveolus development negative regulation of metabolic process reactive oxygen species metabolic process negative regulation of biological process negative regulation of reactive oxygen species metabolic process negative regulation of cellular process regulation of reactive oxygen species metabolic process camera-type eye morphogenesis sensory organ development eye development visual system development eye morphogenesis sensory organ morphogenesis camera-type eye development iris morphogenesis animal organ morphogenesis sensory system development glandular epithelial cell development glandular epithelial cell maturation glandular epithelial cell differentiation digestive tract morphogenesis regulation of body fluid levels secretion transport establishment of localization body fluid secretion localization lactation regulation of biological quality negative regulation of mesenchymal cell apoptotic process mesenchymal cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of mesenchymal cell apoptotic process regulation of programmed cell death negative regulation of apoptotic process response to decreased oxygen levels cellular response to oxygen levels signaling cellular response to hypoxia cellular response to decreased oxygen levels intracellular signal transduction cell communication response to hypoxia hypoxia-inducible factor-1alpha signaling pathway response to oxygen levels response to abiotic stimulus signal transduction vasculature development blood vessel development circulatory system development chondrocyte differentiation protein metabolic process glycoprotein metabolic process elastin metabolic process response to oxygen-containing compound response to reactive oxygen species blood vessel morphogenesis response to peptide cellular response to interleukin-1 response to cytokine cellular response to cytokine stimulus response to interleukin-1 positive regulation of autophagy autophagy regulation of autophagy positive regulation of catabolic process process utilizing autophagic mechanism establishment of organelle localization cellular localization organelle transport along microtubule establishment of mitochondrion localization intracellular transport axonal transport mitochondrion localization establishment of mitochondrion localization, microtubule-mediated axo-dendritic transport mitochondrion transport along microtubule organelle localization establishment of localization in cell microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement microtubule-based process axonal transport of mitochondrion retina vasculature development in camera-type eye retina development in camera-type eye regulation of leukocyte apoptotic process regulation of lymphocyte apoptotic process leukocyte apoptotic process lymphocyte apoptotic process thymocyte apoptotic process regulation of thymocyte apoptotic process regulation of T cell apoptotic process T cell apoptotic process positive regulation of cell communication positive regulation of signal transduction regulation of chemokine-mediated signaling pathway response to chemokine regulation of signal transduction positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway cellular response to chemokine chemokine-mediated signaling pathway positive regulation of response to stimulus positive regulation of chemokine-mediated signaling pathway regulation of G protein-coupled receptor signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of cytokine-mediated signaling pathway positive regulation of G protein-coupled receptor signaling pathway regulation of response to cytokine stimulus regulation of response to stimulus regulation of cell communication G protein-coupled receptor signaling pathway positive regulation of cytokine-mediated signaling pathway positive regulation of signaling placenta development in utero embryonic development embryonic placenta development regulation of protein modification process regulation of post-translational protein modification regulation of protein metabolic process regulation of protein neddylation macromolecule modification regulation of protein modification by small protein conjugation or removal protein modification process post-translational protein modification protein neddylation protein modification by small protein conjugation protein modification by small protein conjugation or removal negative regulation of miRNA transcription negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA-templated transcription negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of miRNA metabolic process negative regulation of RNA metabolic process positive regulation of locomotion regulation of cell motility regulation of blood vessel endothelial cell migration endothelial cell migration positive regulation of cell migration positive regulation of blood vessel endothelial cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration blood vessel endothelial cell migration regulation of endothelial cell migration cell migration cell motility locomotion neuron apoptotic process macroautophagy regulation of macroautophagy positive regulation of macroautophagy collagen metabolic process cell population proliferation regulation of cell population proliferation regulation of cytokine production involved in inflammatory response cytokine production regulation of cytokine production regulation of multicellular organismal process production of molecular mediator involved in inflammatory response defense response cytokine production involved in inflammatory response positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production involved in inflammatory response inflammatory response positive regulation of cytokine production negative regulation of gene expression negative regulation of multicellular organismal process regulation of ossification negative regulation of ossification dopaminergic neuron differentiation generation of neurons neurogenesis neuron differentiation heart development heart morphogenesis outflow tract morphogenesis positive regulation of epithelial cell migration tissue migration ameboidal-type cell migration epithelial cell migration regulation of epithelial cell migration epithelium migration intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis neuroblast proliferation neural precursor cell proliferation glucose homeostasis carbohydrate homeostasis intracellular glucose homeostasis cellular response to growth factor stimulus cell surface receptor protein tyrosine kinase signaling pathway regulation of vascular endothelial growth factor receptor signaling pathway cellular response to endogenous stimulus enzyme-linked receptor protein signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus vascular endothelial growth factor receptor signaling pathway positive regulation of vascular endothelial growth factor receptor signaling pathway response to growth factor cardiac chamber morphogenesis cardiac ventricle morphogenesis cardiac chamber development cardiac ventricle development positive regulation of hormone metabolic process regulation of hormone biosynthetic process regulation of hormone metabolic process regulation of hormone levels hormone metabolic process positive regulation of hormone biosynthetic process hormone biosynthetic process intracellular oxygen homeostasis positive regulation of signaling receptor activity regulation of signaling receptor activity positive regulation of molecular function regulation of molecular function head development forebrain development brain development pallium development cerebral cortex development central nervous system development telencephalon development negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of cell communication negative regulation of TOR signaling regulation of intracellular signal transduction TOR signaling regulation of TOR signaling negative regulation of response to stimulus negative regulation of signal transduction mesenchyme development mesenchymal cell differentiation epithelial to mesenchymal transition regulation of developmental process regulation of cell differentiation regulation of cell development positive regulation of developmental process positive regulation of cell differentiation regulation of immune system process myeloid cell homeostasis erythrocyte homeostasis regulation of multicellular organismal development regulation of myeloid cell differentiation erythrocyte differentiation regulation of erythrocyte differentiation positive regulation of erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process positive regulation of myeloid cell differentiation regulation of hemopoiesis homeostasis of number of cells regulation of transforming growth factor beta production regulation of transforming growth factor beta2 production transforming growth factor beta2 production transforming growth factor beta production intrinsic apoptotic signaling pathway in response to oxidative stress regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of neuron apoptotic process regulation of intrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway intrinsic apoptotic signaling pathway regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway neuron intrinsic apoptotic signaling pathway in response to oxidative stress apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway regulation of neuron apoptotic process regulation of apoptotic signaling pathway regulation of growth negative regulation of growth growth aerobic respiration cellular respiration energy derivation by oxidation of organic compounds regulation of cellular respiration regulation of aerobic respiration transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II pattern specification process embryonic heart tube development embryonic heart tube morphogenesis heart looping determination of bilateral symmetry determination of left/right symmetry specification of symmetry embryonic organ morphogenesis determination of heart left/right asymmetry regionalization left/right pattern formation muscle cell cellular homeostasis regulation of vascular endothelial growth factor production vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production angiogenesis wound healing connective tissue replacement involved in inflammatory response wound healing wound healing involved in inflammatory response inflammatory response to wounding tissue remodeling connective tissue replacement response to wounding organic hydroxy compound metabolic process lactate metabolic process stem cell development neural crest cell differentiation neural crest cell development mesenchymal cell migration stem cell differentiation neural crest cell migration response to light stimulus system process learning learning or memory nervous system process visual learning visual behavior cognition associative learning behavior response to radiation protein localization establishment of protein localization nitrogen compound transport cellular macromolecule localization establishment of protein localization to extracellular region protein secretion cellular response to oxygen-containing compound cellular response to carbohydrate stimulus response to glucose insulin secretion involved in cellular response to glucose stimulus hormone secretion protein localization to extracellular region peptide secretion secretion by cell response to monosaccharide response to carbohydrate amide transport signal release cellular response to hexose stimulus cellular response to monosaccharide stimulus cell-cell signaling export from cell cellular response to glucose stimulus peptide transport response to hexose protein transport peptide hormone secretion macromolecule localization hormone transport insulin secretion regulation of localization positive regulation of establishment of protein localization positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of insulin secretion regulation of peptide hormone secretion positive regulation of peptide hormone secretion regulation of protein secretion regulation of secretion positive regulation of protein localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion positive regulation of secretion by cell positive regulation of protein transport regulation of secretion by cell positive regulation of hormone secretion positive regulation of secretion positive regulation of peptide secretion regulation of transport regulation of peptide transport regulation of establishment of protein localization regulation of protein transport positive regulation of protein secretion positive regulation of transport regulation of cellular localization regulation of insulin secretion regulation of insulin secretion involved in cellular response to glucose stimulus hemoglobin biosynthetic process hemoglobin metabolic process regulation of vasculature development regulation of anatomical structure morphogenesis positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis B cell homeostasis leukocyte homeostasis B-1 B cell homeostasis lymphocyte homeostasis positive regulation of autophagy of mitochondrion mitophagy regulation of autophagy of mitochondrion positive regulation of mitophagy regulation of mitophagy autophagy of mitochondrion negative regulation of thymocyte apoptotic process negative regulation of leukocyte apoptotic process negative regulation of T cell apoptotic process negative regulation of lymphocyte apoptotic process positive regulation of nervous system development positive regulation of cell population proliferation regulation of neuroblast proliferation regulation of neurogenesis regulation of nervous system development positive regulation of neurogenesis regulation of neural precursor cell proliferation positive regulation of cell development positive regulation of neural precursor cell proliferation positive regulation of neuroblast proliferation cellular response to virus biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus negative regulation of biomineral tissue development regulation of biomineral tissue development regulation of bone mineralization negative regulation of bone mineralization negative regulation of developmental process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen cytoplasm cytosol neuron projection cytoplasm axon axon cytoplasm neuron projection cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection cell projection cilium motile cilium euchromatin membraneless organelle intracellular membraneless organelle chromatin chromosome protein-containing complex transcription regulator complex RNA polymerase II transcription regulator complex nuclear protein-containing complex
C	DNA (5'-D(GPGPCPTPGPCPGPTPAPCPGPTPGPCPGPGPGPTPCPGP*T)-3')	-	-	-
D	DNA (5'-D(CPAPCPGPAPCPCPCPGPCPAPCPGPTPAPCPGPCPAPGP*C)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR050933	Circadian Clock Transcription Factors	Family
A	IPR013767	PAS fold	Domain
A	IPR001067	Nuclear translocator	Family
A	IPR000014	PAS domain	Domain
A	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	Domain
A	IPR035965	PAS domain superfamily	Homologous Superfamily
A	IPR001610	PAC motif	Repeat
A	IPR036638	Helix-loop-helix DNA-binding domain superfamily	Homologous Superfamily
B	IPR013655	PAS fold-3	Domain
B	IPR001321	Hypoxia-inducible factor-1 alpha	Family
B	IPR035965	PAS domain superfamily	Homologous Superfamily
B	IPR014887	HIF-1 alpha, C-terminal transactivation domain	Domain
B	IPR000014	PAS domain	Domain
B	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	Domain
B	IPR001610	PAC motif	Repeat
B	IPR036638	Helix-loop-helix DNA-binding domain superfamily	Homologous Superfamily
B	IPR021537	Hypoxia-inducible factor, alpha subunit-like	Domain
B	IPR013767	PAS fold	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.