4XSS | pdb_00004xss

Insulin-like growth factor I in complex with site 1 of a hybrid insulin receptor / Type 1 insulin-like growth factor receptor

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth E]	SCOP2B Superfamily	Growth factor receptor domain-like	8032837	3000398	SCOP2B (2022-06-29)
B [auth E]	SCOP2B Superfamily	L domain-like	8032830	3001010	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	Insulin	e4xssB1	A: few secondary structure elements	X: Insulin-like (From Topology)	H: Insulin-like (From Topology)	T: Insulin-like	F: Insulin	ECOD (1.6)
B [auth E]	Recep_L_domain	e4xssE2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: Recep_L_domain	ECOD (1.6)
B [auth E]	Furin-like_5	e4xssE1	A: few secondary structure elements	X: EGF-like	H: Growth factor receptor domain (From Topology)	T: Growth factor receptor domain	F: Furin-like_5	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	1.10.100.10	Mainly Alpha	Orthogonal Bundle	Insulin-like, subunit E	Insulin-like	CATH (4.3.0)
B [auth E]	3.80.20.20	Alpha Beta	Alpha-Beta Horseshoe	24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'	Chain A	CATH (4.3.0)
B [auth E]	2.10.220.10	Mainly Beta	Ribbon	Hormone Receptor, Insulin-like Growth Factor Receptor 1	Chain A domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B]	PF00049	Insulin/IGF/Relaxin family (Insulin)	Insulin/IGF/Relaxin family	Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain.	Domain
B [auth E]	PF00757	Furin-like cysteine rich region (Furin-like)	Furin-like cysteine rich region		Domain
B [auth E]	PF01030	Receptor L domain (Recep_L_domain)	Receptor L domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	Insulin-like growth factor I	molecular transducer activity binding molecular function activator activity signaling receptor binding signaling receptor activity growth factor activity signaling receptor activator activity protein binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity insulin receptor binding insulin-like growth factor receptor binding cell adhesion molecule binding molecular transducer activity binding molecular function activator activity signaling receptor binding signaling receptor activity growth factor activity signaling receptor activator activity protein binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity insulin receptor binding insulin-like growth factor receptor binding cell adhesion molecule binding protein-containing complex binding integrin binding hormone activity	regulation of molecular function positive regulation of molecular function regulation of DNA binding regulation of binding biological regulation positive regulation of binding positive regulation of DNA binding multicellular organismal process regulation of tumor necrosis factor production regulation of cellular process negative regulation of biological process negative regulation of tumor necrosis factor production cytokine production regulation of cytokine production regulation of molecular function positive regulation of molecular function regulation of DNA binding regulation of binding biological regulation positive regulation of binding positive regulation of DNA binding multicellular organismal process regulation of tumor necrosis factor production regulation of cellular process negative regulation of biological process negative regulation of tumor necrosis factor production cytokine production regulation of cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process negative regulation of metabolic process tumor necrosis factor superfamily cytokine production negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process tumor necrosis factor production regulation of gene expression negative regulation of gene expression regulation of tumor necrosis factor superfamily cytokine production biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of tumor necrosis factor superfamily cytokine production metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process regulation of protein stability regulation of biological quality protein stabilization cell activation myoblast proliferation cell population proliferation developmental process muscle structure development cellular developmental process cell differentiation anatomical structure development myoblast differentiation regulation of protein modification process positive regulation of phosphorylation regulation of catalytic activity regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein metabolic process activation of protein kinase B activity positive regulation of protein kinase activity phosphorus metabolic process protein modification process positive regulation of protein phosphorylation positive regulation of cellular process protein phosphorylation positive regulation of transferase activity positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of catalytic activity primary metabolic process regulation of protein kinase activity positive regulation of kinase activity regulation of kinase activity activation of protein kinase activity macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process multicellular organism development skeletal system development system development positive regulation of macromolecule biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process cellular response to stimulus cell surface receptor signaling pathway via STAT cell surface receptor signaling pathway response to stimulus signaling cell communication signal transduction myotube cell development cell development muscle cell differentiation myotube differentiation striated muscle cell development muscle cell development striated muscle cell differentiation animal organ development muscle organ development regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response defense response negative regulation of response to stimulus response to external stimulus regulation of inflammatory response regulation of response to stimulus response to stress negative regulation of response to external stimulus regulation of response to stress regulation of neuroinflammatory response negative regulation of defense response inflammatory response negative regulation of neuroinflammatory response neuroinflammatory response positive regulation of transcription regulatory region DNA binding regulation of transcription regulatory region DNA binding insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway positive regulation of locomotion regulation of cell motility positive regulation of smooth muscle cell migration regulation of smooth muscle cell migration positive regulation of cell migration smooth muscle cell migration muscle cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion muscle hypertrophy system process muscle system process positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division mitotic cell cycle cellular component organization regulation of mitotic cell cycle positive regulation of cell cycle process cellular component organization or biogenesis cell cycle regulation of cell cycle cell cycle process mitotic nuclear division regulation of cell cycle process organelle fission positive regulation of nuclear division regulation of organelle organization positive regulation of cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division bone maturation bone mineralization bone mineralization involved in bone maturation developmental maturation tissue development ossification anatomical structure maturation biomineral tissue development ossification involved in bone maturation animal organ maturation bone development positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction positive regulation of response to stimulus positive regulation of insulin-like growth factor receptor signaling pathway regulation of insulin-like growth factor receptor signaling pathway regulation of signaling regulation of cell communication positive regulation of signaling negative regulation of signaling apoptotic mitochondrial changes regulation of release of cytochrome c from mitochondria regulation of programmed cell death negative regulation of cell communication negative regulation of release of cytochrome c from mitochondria negative regulation of apoptotic signaling pathway mitochondrion organization negative regulation of cellular component organization negative regulation of programmed cell death regulation of apoptotic process cell death negative regulation of signal transduction apoptotic signaling pathway release of cytochrome c from mitochondria negative regulation of apoptotic process negative regulation of organelle organization regulation of mitochondrion organization apoptotic process programmed cell death regulation of apoptotic signaling pathway mesenchyme development mesenchymal cell differentiation epithelial to mesenchymal transition amyloid precursor protein catabolic process regulation of amide metabolic process regulation of amyloid-beta formation regulation of amyloid precursor protein catabolic process negative regulation of amyloid precursor protein catabolic process amyloid-beta metabolic process amide metabolic process amyloid precursor protein metabolic process negative regulation of protein metabolic process amyloid-beta formation negative regulation of amyloid-beta formation negative regulation of amide metabolic process regulation of muscle adaptation positive regulation of cardiac muscle hypertrophy regulation of system process striated muscle hypertrophy regulation of muscle system process regulation of cardiac muscle hypertrophy regulation of muscle hypertrophy muscle adaptation positive regulation of muscle hypertrophy cardiac muscle hypertrophy positive regulation of multicellular organismal process regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway regulation of growth regulation of cardiac muscle tissue growth developmental growth regulation of cell differentiation positive regulation of developmental process regulation of organ growth regulation of heart growth cardiac muscle tissue growth muscle tissue development cardiac cell development positive regulation of developmental growth positive regulation of heart growth heart growth positive regulation of organ growth positive regulation of muscle cell differentiation regulation of muscle cell differentiation positive regulation of cardiac muscle tissue growth positive regulation of cell growth involved in cardiac muscle cell development regulation of developmental process cardiac muscle cell development regulation of striated muscle cell differentiation organ growth cell growth striated muscle tissue development positive regulation of cell differentiation positive regulation of striated muscle cell differentiation heart development regulation of multicellular organismal development regulation of developmental growth cardiac muscle tissue development developmental cell growth physiological muscle hypertrophy growth cardiac muscle cell differentiation regulation of cell growth involved in cardiac muscle cell development positive regulation of cell growth regulation of cell growth cardiocyte differentiation circulatory system development cell growth involved in cardiac muscle cell development positive regulation of growth physiological cardiac muscle hypertrophy response to heat response to abiotic stimulus response to temperature stimulus positive regulation of DNA-templated transcription RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription tissue regeneration skeletal muscle tissue regeneration skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration maintenance of cell number regeneration ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process organophosphate catabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process regulation of ATP metabolic process regulation of purine nucleotide catabolic process positive regulation of nucleotide catabolic process regulation of small molecule metabolic process glycolytic process regulation of nucleotide metabolic process pyridine-containing compound metabolic process small molecule metabolic process purine ribonucleotide catabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process regulation of carbohydrate catabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process positive regulation of ATP metabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process positive regulation of carbohydrate metabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process ATP metabolic process catabolic process positive regulation of nucleotide metabolic process positive regulation of purine nucleotide catabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process ribonucleoside triphosphate metabolic process nucleotide catabolic process purine nucleoside triphosphate metabolic process carbohydrate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process positive regulation of glycolytic process ADP catabolic process carboxylic acid metabolic process generation of precursor metabolites and energy regulation of catabolic process regulation of glycolytic process purine-containing compound metabolic process positive regulation of purine nucleotide metabolic process positive regulation of catabolic process ADP metabolic process organophosphate metabolic process purine ribonucleoside diphosphate metabolic process positive regulation of small molecule metabolic process purine ribonucleoside diphosphate catabolic process sexual reproduction regulation of oogenesis regulation of reproductive process reproductive process cellular process involved in reproduction in multicellular organism developmental process involved in reproduction female gamete generation gamete generation regulation of cell development oocyte development negative regulation of cell differentiation negative regulation of developmental process regulation of oocyte development multicellular organismal reproductive process oogenesis negative regulation of cell development negative regulation of reproductive process negative regulation of oocyte development germ cell development oocyte differentiation intracellular signal transduction positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of glycogen metabolic process carbohydrate biosynthetic process hexose metabolic process positive regulation of glucose metabolic process positive regulation of glycogen biosynthetic process energy reserve metabolic process regulation of glycogen metabolic process monosaccharide metabolic process regulation of glycogen biosynthetic process glucan biosynthetic process energy derivation by oxidation of organic compounds regulation of glucan biosynthetic process regulation of polysaccharide metabolic process polysaccharide metabolic process glucan metabolic process regulation of glucose metabolic process polysaccharide biosynthetic process glycogen metabolic process glycogen biosynthetic process regulation of polysaccharide biosynthetic process regulation of carbohydrate biosynthetic process glucose metabolic process fibroblast proliferation regulation of fibroblast proliferation positive regulation of fibroblast proliferation positive regulation of glycoprotein metabolic process regulation of glycoprotein biosynthetic process positive regulation of glycoprotein biosynthetic process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process glycoprotein metabolic process regulation of glycoprotein metabolic process interleukin-1 production regulation of interleukin-1 beta production negative regulation of interleukin-1 beta production negative regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell proliferation vascular associated smooth muscle cell proliferation calcineurin-NFAT signaling cascade regulation of calcineurin-mediated signaling positive regulation of calcineurin-NFAT signaling cascade regulation of calcium-mediated signaling positive regulation of calcium-mediated signaling regulation of calcineurin-NFAT signaling cascade positive regulation of calcineurin-mediated signaling calcium-mediated signaling calcineurin-mediated signaling positive regulation of epithelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction alcohol metabolic process glycolate metabolic process primary alcohol metabolic process small GTPase-mediated signal transduction Ras protein signal transduction regulation of leukocyte activation regulation of cell activation positive regulation of cell activation T cell activation lymphocyte proliferation positive regulation of leukocyte activation regulation of immune system process positive regulation of immune system process regulation of leukocyte proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation mononuclear cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation regulation of activated T cell proliferation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation activated T cell proliferation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation cell adhesion cell-cell adhesion positive regulation of mononuclear cell proliferation regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation regulation of T cell proliferation immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization transport positive regulation of establishment of protein localization positive regulation of secretion by cell protein localization to extracellular region positive regulation of protein transport localization regulation of secretion by cell secretion by cell positive regulation of secretion cellular macromolecule localization regulation of transport secretion regulation of establishment of protein localization establishment of protein localization to extracellular region export from cell regulation of protein transport protein secretion establishment of localization positive regulation of protein secretion regulation of protein secretion regulation of secretion positive regulation of transport protein transport regulation of cellular localization macromolecule localization positive regulation of protein localization proteoglycan biosynthetic process proteoglycan metabolic process muscle cell apoptotic process smooth muscle cell apoptotic process regulation of muscle cell apoptotic process regulation of smooth muscle cell apoptotic process negative regulation of vascular associated smooth muscle cell apoptotic process vascular associated smooth muscle cell apoptotic process negative regulation of smooth muscle cell apoptotic process negative regulation of muscle cell apoptotic process regulation of vascular associated smooth muscle cell apoptotic process regulation of osteoblast differentiation osteoblast differentiation positive regulation of osteoblast differentiation chordate embryonic development embryo development trophectodermal cell proliferation embryo development ending in birth or egg hatching in utero embryonic development positive regulation of trophectodermal cell proliferation regulation of trophectodermal cell proliferation blastocyst growth blastocyst development wound healing response to wounding hexose transmembrane transport D-glucose import carbohydrate transport positive regulation of D-glucose transmembrane transport positive regulation of transmembrane transport regulation of D-glucose import positive regulation of D-glucose import transmembrane transport regulation of transmembrane transport D-glucose transmembrane transport regulation of D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport cellular response to nitrogen compound response to oxygen-containing compound response to nitrogen compound cellular response to amyloid-beta cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical response to amyloid-beta regulation of small GTPase mediated signal transduction regulation of Ras protein signal transduction positive regulation of Ras protein signal transduction positive regulation of small GTPase mediated signal transduction peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation peptidyl-amino acid modification regulation of peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation	cell periphery protein-containing complex cellular anatomical structure plasma membrane protein complex membrane plasma membrane alphav-beta3 integrin-IGF-1-IGF1R complex membrane protein complex membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen cell periphery protein-containing complex cellular anatomical structure plasma membrane protein complex membrane plasma membrane alphav-beta3 integrin-IGF-1-IGF1R complex membrane protein complex membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen intracellular membrane-bounded organelle secretory granule lumen endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle cytoplasm platelet alpha granule vesicle platelet alpha granule lumen extracellular region extracellular space insulin-like growth factor binding protein complex growth factor complex transport vesicle exocytic vesicle insulin-like growth factor ternary complex
B [auth E]	Insulin receptor	molecular transducer activity catalytic activity, acting on a protein ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane-ephrin receptor activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity molecular transducer activity catalytic activity, acting on a protein ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane-ephrin receptor activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity collagen receptor activity protein tyrosine kinase collagen receptor activity amide binding amyloid-beta binding binding peptide binding GPI-linked ephrin receptor activity protein binding peptide hormone binding hormone binding insulin binding protein-hormone receptor activity insulin receptor activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding platelet-derived growth factor beta-receptor activity platelet-derived growth factor receptor activity stem cell factor receptor activity protein-containing complex binding brain-derived neurotrophic factor receptor activity neurotrophin receptor activity hepatocyte growth factor receptor activity insulin-like growth factor receptor binding signaling receptor binding protein domain specific binding macrophage colony-stimulating factor receptor activity enzyme regulator activity molecular function activator activity protein kinase regulator activity kinase activator activity enzyme activator activity molecular function regulator activity protein kinase activator activity kinase regulator activity platelet-derived growth factor alpha-receptor activity guanyl nucleotide binding GTP binding guanyl ribonucleotide binding vascular endothelial growth factor receptor activity histone H2AXY142 kinase activity histone modifying activity histone kinase activity histone H2AX kinase activity insulin receptor substrate binding PTB domain binding histone H3Y41 kinase activity histone H3 kinase activity phosphatidylinositol 3-kinase binding placental growth factor receptor activity insulin-like growth factor receptor activity identical protein binding boss receptor activity epidermal growth factor receptor activity insulin-like growth factor binding insulin-like growth factor II binding growth factor binding cargo receptor activity insulin-like growth factor I binding fibroblast growth factor receptor activity	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process cellular process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process cellular process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process positive regulation of cellular process cellular component disassembly positive regulation of cellular component organization regulation of cellular component organization protein-containing complex organization protein-containing complex disassembly regulation of protein-containing complex disassembly cellular component organization cellular component organization or biogenesis positive regulation of protein-containing complex disassembly regulation of protein modification process positive regulation of phosphorylation regulation of catalytic activity regulation of protein phosphorylation positive regulation of protein metabolic process regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of molecular function positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein metabolic process activation of protein kinase B activity positive regulation of protein kinase activity phosphorus metabolic process protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of transferase activity positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of catalytic activity primary metabolic process regulation of protein kinase activity regulation of macromolecule metabolic process regulation of molecular function positive regulation of kinase activity regulation of kinase activity activation of protein kinase activity macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process macromolecule metabolic process biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction developmental process regulation of growth regulation of developmental growth regulation of developmental process developmental growth growth positive regulation of developmental process positive regulation of growth positive regulation of developmental growth behavior multicellular organismal process system process learning or memory nervous system process cognition memory positive regulation of organelle organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division mitotic cell cycle regulation of mitotic cell cycle positive regulation of cell cycle process cell cycle regulation of cell cycle cell cycle process mitotic nuclear division regulation of cell cycle process organelle fission positive regulation of nuclear division regulation of organelle organization positive regulation of cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of DNA-templated transcription localization circulatory system process transport vascular process in circulatory system vascular transport establishment of localization transport across blood-brain barrier ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process organophosphate catabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process regulation of ATP metabolic process regulation of purine nucleotide catabolic process positive regulation of nucleotide catabolic process regulation of small molecule metabolic process glycolytic process regulation of nucleotide metabolic process pyridine-containing compound metabolic process small molecule metabolic process purine ribonucleotide catabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process regulation of carbohydrate catabolic process positive regulation of nucleobase-containing compound metabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process positive regulation of ATP metabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process positive regulation of carbohydrate metabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process ATP metabolic process catabolic process positive regulation of nucleotide metabolic process positive regulation of purine nucleotide catabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process ribonucleoside triphosphate metabolic process nucleotide catabolic process purine nucleoside triphosphate metabolic process carbohydrate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process positive regulation of glycolytic process ADP catabolic process carboxylic acid metabolic process generation of precursor metabolites and energy regulation of catabolic process regulation of glycolytic process purine-containing compound metabolic process positive regulation of purine nucleotide metabolic process positive regulation of catabolic process ADP metabolic process organophosphate metabolic process purine ribonucleoside diphosphate metabolic process positive regulation of small molecule metabolic process purine ribonucleoside diphosphate catabolic process positive regulation of macromolecule biosynthetic process positive regulation of glycogen metabolic process carbohydrate biosynthetic process hexose metabolic process positive regulation of glucose metabolic process positive regulation of glycogen biosynthetic process energy reserve metabolic process regulation of glycogen metabolic process monosaccharide metabolic process regulation of glycogen biosynthetic process glucan biosynthetic process energy derivation by oxidation of organic compounds regulation of glucan biosynthetic process regulation of polysaccharide metabolic process polysaccharide metabolic process glucan metabolic process regulation of glucose metabolic process polysaccharide biosynthetic process glycogen metabolic process glycogen biosynthetic process regulation of polysaccharide biosynthetic process regulation of carbohydrate biosynthetic process glucose metabolic process epidermis development anatomical structure development tissue development cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus regulation of signal transduction regulation of MAP kinase activity intracellular signal transduction cell communication positive regulation of protein serine/threonine kinase activity intracellular signaling cassette signal transduction positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus regulation of protein serine/threonine kinase activity signaling positive regulation of response to stimulus regulation of intracellular signal transduction regulation of signaling MAPK cascade regulation of cell communication positive regulation of signaling dendritic spine maintenance dendritic spine organization postsynapse organization plasma membrane bounded cell projection organization cell projection organization cellular component maintenance cell junction organization neuron projection organization synapse organization multicellular organism development adrenal gland development endocrine system development gland development animal organ development system development cellular response to nitrogen compound response to peptide hormone insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus response to hormone enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus cell surface receptor signaling pathway response to endogenous stimulus response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical response to insulin cellular response to insulin stimulus positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion regulation of embryonic development regulation of multicellular organismal development embryo development regulation of multicellular organismal process G protein-coupled receptor signaling pathway regulation of localization hexose transmembrane transport D-glucose import carbohydrate transport positive regulation of D-glucose transmembrane transport positive regulation of transmembrane transport regulation of D-glucose import positive regulation of D-glucose import regulation of transport transmembrane transport regulation of transmembrane transport positive regulation of transport D-glucose transmembrane transport regulation of D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport neuron projection maintenance gonad development reproductive system development reproductive process sex differentiation developmental process involved in reproduction male gonad development male sex differentiation development of primary male sexual characteristics development of primary sexual characteristics reproductive structure development learning import into cell receptor internalization receptor-mediated endocytosis endocytosis vesicle-mediated transport protein autophosphorylation heart development heart morphogenesis circulatory system development anatomical structure morphogenesis animal organ morphogenesis digestive system development exocrine pancreas development pancreas development exocrine system development positive regulation of respiratory burst respiratory burst regulation of respiratory burst regulation of meiotic cell cycle sexual reproduction regulation of reproductive process meiotic cell cycle positive regulation of meiotic cell cycle positive regulation of reproductive process chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis sex determination male sex determination regulation of receptor internalization positive regulation of endocytosis positive regulation of receptor-mediated endocytosis regulation of endocytosis regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport positive regulation of receptor internalization amyloid-beta clearance regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of gonad development development of primary female sexual characteristics regulation of female gonad development female gonad development female sex differentiation peptidyl-tyrosine modification peptidyl-amino acid modification peptidyl-tyrosine phosphorylation positive regulation of DNA-templated transcription positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process	protein-containing complex receptor complex endosome membrane membrane-bounded organelle intracellular anatomical structure membrane endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle protein-containing complex receptor complex endosome membrane membrane-bounded organelle intracellular anatomical structure membrane endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle cytoplasm vesicle organelle membrane membrane microdomain cell periphery membrane raft plasma membrane raft plasma membrane plasma membrane region caveola lytic vacuole vacuole lysosome cell leading edge neuron projection leading edge membrane plasma membrane bounded cell projection somatodendritic compartment neuron projection membrane cell projection dendrite membrane dendrite dendritic tree cell projection membrane late endosome cell surface external side of plasma membrane side of membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle neuronal cell body membrane cell body cell body membrane neuronal cell body axon catalytic complex plasma membrane protein complex membrane protein complex transferase complex protein kinase complex transferase complex, transferring phosphorus-containing groups insulin receptor complex plasma membrane signaling receptor complex
C [auth F]	Insulin-like growth factor receptor alpha-CT peptide	molecular transducer activity catalytic activity, acting on a protein ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane-ephrin receptor activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity molecular transducer activity catalytic activity, acting on a protein ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane-ephrin receptor activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity collagen receptor activity protein tyrosine kinase collagen receptor activity GPI-linked ephrin receptor activity amide binding protein binding binding peptide hormone binding hormone binding insulin binding protein-hormone receptor activity insulin receptor activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding platelet-derived growth factor beta-receptor activity platelet-derived growth factor receptor activity stem cell factor receptor activity protein-containing complex binding brain-derived neurotrophic factor receptor activity neurotrophin receptor activity G-protein alpha-subunit binding hepatocyte growth factor receptor activity macrophage colony-stimulating factor receptor activity platelet-derived growth factor alpha-receptor activity vascular endothelial growth factor receptor activity histone H2AXY142 kinase activity histone modifying activity histone kinase activity histone H2AX kinase activity insulin-like growth factor binding growth factor binding insulin receptor substrate binding histone H3Y41 kinase activity histone H3 kinase activity signaling receptor binding insulin receptor binding phosphatidylinositol 3-kinase binding placental growth factor receptor activity insulin-like growth factor receptor activity identical protein binding boss receptor activity epidermal growth factor receptor activity insulin-like growth factor I binding protein transporter activity transporter activity fibroblast growth factor receptor activity	cellular component disassembly regulation of biological process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization protein-containing complex organization biological regulation positive regulation of biological process protein-containing complex disassembly regulation of protein-containing complex disassembly cellular component organization cellular process cellular component organization or biogenesis positive regulation of protein-containing complex disassembly cellular component disassembly regulation of biological process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization protein-containing complex organization biological regulation positive regulation of biological process protein-containing complex disassembly regulation of protein-containing complex disassembly cellular component organization cellular process cellular component organization or biogenesis positive regulation of protein-containing complex disassembly positive regulation of cellular process cellular response to stimulus cellular response to nitrogen compound response to stimulus response to endogenous stimulus response to peptide hormone cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical cellular response to insulin-like growth factor stimulus cellular response to hormone stimulus regulation of cytokinesis positive regulation of cell division regulation of cell cycle process cytokinesis positive regulation of cell cycle regulation of cell division positive regulation of cytokinesis positive regulation of cell cycle process cell division cell cycle regulation of cell cycle cell cycle process developmental process multicellular organismal process head development animal organ development brain development nervous system development multicellular organism development cerebellum development central nervous system development metencephalon development anatomical structure development hindbrain development system development cell surface receptor signaling pathway signaling insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell communication signal transduction enzyme-linked receptor protein signaling pathway axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation plasma membrane bounded cell projection organization axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development regulation of epithelial cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death epithelial cell apoptotic process negative regulation of cholangiocyte apoptotic process negative regulation of apoptotic process negative regulation of epithelial cell apoptotic process negative regulation of cellular process apoptotic process cholangiocyte apoptotic process regulation of cholangiocyte apoptotic process programmed cell death cell population proliferation positive regulation of cell population proliferation positive regulation of osteoblast proliferation osteoblast proliferation regulation of cell population proliferation regulation of osteoblast proliferation response to nutrient levels response to zinc ion starvation cellular response to starvation cellular response to nutrient levels cellular response to stress response to stress response to starvation cellular response to zinc ion starvation regulation of smooth muscle cell proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation muscle cell proliferation response to nutrient response to vitamin E response to vitamin positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process DNA metabolic process nucleic acid metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process positive regulation of DNA metabolic process metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process immune response immune system process homeostatic process cellular response to glucose stimulus intracellular glucose homeostasis response to hexose cellular response to carbohydrate stimulus cellular homeostasis response to monosaccharide response to carbohydrate chemical homeostasis response to glucose glucose homeostasis carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus response to ketone response to lipid cellular response to mineralocorticoid stimulus response to mineralocorticoid cellular response to aldehyde response to steroid hormone cellular response to ketone cellular response to steroid hormone stimulus cellular response to aldosterone response to aldosterone response to alcohol cellular response to corticosteroid stimulus response to corticosteroid cellular response to alcohol cellular response to lipid negative regulation of signaling negative regulation of intracellular signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication regulation of intracellular signal transduction intracellular signaling cassette regulation of signaling negative regulation of response to stimulus regulation of MAPK cascade negative regulation of signal transduction regulation of response to stimulus MAPK cascade regulation of cell communication negative regulation of MAPK cascade dendritic spine maintenance dendritic spine organization postsynapse organization cellular component maintenance cell junction organization neuron projection organization synapse organization response to mechanical stimulus response to external stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus insulin receptor signaling pathway response to insulin cellular response to insulin stimulus positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion cellular response to testosterone stimulus response to testosterone response to estradiol cellular response to estradiol stimulus response to alkaloid cellular response to amyloid-beta response to amyloid-beta positive regulation of neuron projection regeneration regulation of cellular response to stress regeneration neuron projection regeneration positive regulation of developmental process positive regulation of cell projection organization response to wounding positive regulation of response to wounding regulation of axon regeneration regulation of cell projection organization regulation of neuron projection regeneration regulation of neuron projection development regulation of developmental process regulation of response to external stimulus response to axon injury regulation of response to wounding positive regulation of response to stimulus positive regulation of response to external stimulus axon regeneration positive regulation of neuron projection development regulation of response to stress positive regulation of axon regeneration regulation of plasma membrane bounded cell projection organization protein phosphorylation protein autophosphorylation phosphorylation peptidyl-tyrosine modification peptidyl-tyrosine autophosphorylation macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process protein metabolic process peptidyl-tyrosine phosphorylation protein modification process phosphorus metabolic process regulation of JNK cascade JNK cascade ovulation cycle rhythmic process estrous cycle reproductive process multicellular organismal reproductive process response to progesterone cellular response to progesterone stimulus establishment of cell polarity establishment or maintenance of cell polarity negative regulation of hepatocyte apoptotic process regulation of hepatocyte apoptotic process hepatocyte apoptotic process cellular response to dexamethasone stimulus response to glucocorticoid cellular response to glucocorticoid stimulus response to dexamethasone cellular senescence response to acid chemical response to L-glutamate response to amino acid forebrain development pallium development telencephalon development hippocampus development limbic system development phosphatidylinositol 3-kinase/protein kinase B signal transduction cellular response to growth factor stimulus response to transforming growth factor beta cellular response to transforming growth factor beta stimulus response to growth factor amyloid-beta clearance heart development cardiac chamber development cardiac atrium development circulatory system development positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signal transduction positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling regulation of steroid biosynthetic process positive regulation of steroid hormone biosynthetic process regulation of hormone biosynthetic process regulation of hormone metabolic process regulation of lipid metabolic process steroid metabolic process lipid biosynthetic process positive regulation of biosynthetic process positive regulation of lipid metabolic process regulation of biological quality hormone biosynthetic process steroid biosynthetic process regulation of biosynthetic process regulation of steroid hormone biosynthetic process positive regulation of hormone metabolic process regulation of hormone levels regulation of steroid metabolic process hormone metabolic process positive regulation of steroid biosynthetic process biosynthetic process positive regulation of lipid biosynthetic process positive regulation of steroid metabolic process positive regulation of hormone biosynthetic process regulation of lipid biosynthetic process lipid metabolic process response to ethanol adaptive thermogenesis multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process regulation of multicellular organismal process positive regulation of MAPK cascade localization transport establishment of localization transcytosis vesicle-mediated transport muscle cell apoptotic process regulation of muscle cell apoptotic process negative regulation of muscle cell apoptotic process response to nicotine response to angiotensin cellular response to angiotensin	cell periphery cellular anatomical structure sarcolemma plasma membrane membrane T-tubule protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex transferase complex receptor complex membrane microdomain membrane raft cell periphery cellular anatomical structure sarcolemma plasma membrane membrane T-tubule protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex transferase complex receptor complex membrane microdomain membrane raft plasma membrane raft plasma membrane region caveola membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle plasma membrane protein complex alphav-beta3 integrin-IGF-1-IGF1R complex membrane protein complex somatodendritic compartment cell body neuronal cell body axon cell projection neuron projection plasma membrane bounded cell projection insulin receptor complex plasma membrane signaling receptor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B]	IPR022350	Insulin-like growth factor	Family
A [auth B]	IPR022353	Insulin, conserved site	Conserved Site
A [auth B]	IPR036438	Insulin-like superfamily	Homologous Superfamily
A [auth B]	IPR022352	Insulin family	Family
A [auth B]	IPR016179	Insulin-like	Domain
A [auth B]	IPR022341	Insulin-like growth factor I	Family
B [auth E]	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
B [auth E]	IPR000719	Protein kinase domain	Domain
B [auth E]	IPR006212	Furin-like repeat	Repeat
B [auth E]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B [auth E]	IPR017441	Protein kinase, ATP binding site	Binding Site
B [auth E]	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
B [auth E]	IPR002011	Tyrosine-protein kinase, receptor class II, conserved site	Conserved Site
B [auth E]	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
B [auth E]	IPR008266	Tyrosine-protein kinase, active site	Active Site
B [auth E]	IPR036941	Receptor L-domain superfamily	Homologous Superfamily
B [auth E]	IPR000494	Receptor L-domain	Domain
B [auth E]	IPR003961	Fibronectin type III	Domain
B [auth E]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B [auth E]	IPR006211	Furin-like cysteine-rich domain	Domain
B [auth E]	IPR050122	Receptor Tyrosine Kinase	Family
B [auth E]	IPR016246	Tyrosine-protein kinase, insulin-like receptor	Family
B [auth E]	IPR040969	Insulin receptor, trans-membrane domain	Domain
B [auth E]	IPR036116	Fibronectin type III superfamily	Homologous Superfamily
C [auth F]	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
C [auth F]	IPR000719	Protein kinase domain	Domain
C [auth F]	IPR006212	Furin-like repeat	Repeat
C [auth F]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
C [auth F]	IPR017441	Protein kinase, ATP binding site	Binding Site
C [auth F]	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
C [auth F]	IPR002011	Tyrosine-protein kinase, receptor class II, conserved site	Conserved Site
C [auth F]	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
C [auth F]	IPR008266	Tyrosine-protein kinase, active site	Active Site
C [auth F]	IPR036941	Receptor L-domain superfamily	Homologous Superfamily
C [auth F]	IPR000494	Receptor L-domain	Domain
C [auth F]	IPR003961	Fibronectin type III	Domain
C [auth F]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
C [auth F]	IPR006211	Furin-like cysteine-rich domain	Domain
C [auth F]	IPR050122	Receptor Tyrosine Kinase	Family
C [auth F]	IPR016246	Tyrosine-protein kinase, insulin-like receptor	Family
C [auth F]	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B]	Pharos: P05019	growth delay due to insulin-like growth factor type 1 deficiency acromegaly hypertensive disorder breast carcinoma muscular atrophy kidney disease adenoma Crohn disease Alzheimer disease precocious puberty pituitary gland adenoma microcystic adenoma pulmonary fibrosis Neoplasm Invasiveness skin neoplasm growth delay due to insulin-like growth factor type 1 deficiency acromegaly hypertensive disorder breast carcinoma muscular atrophy kidney disease adenoma Crohn disease Alzheimer disease precocious puberty pituitary gland adenoma microcystic adenoma pulmonary fibrosis Neoplasm Invasiveness skin neoplasm endometriosis cholestasis colitis coronary artery disease papillary adenoma pituitary adenocarcinoma demyelinating disease chronic kidney disease follicular thyroid adenoma urinary bladder cancer peripheral nervous system disease prostate cancer middle cerebral artery infarction breast cancer myopathy skin cancer corneal disease peripheral neuropathy amyotrophic lateral sclerosis medulloblastoma depressive disorder autism prostate disease hypopituitarism bipolar disorder ileocolitis Silver-Russell syndrome interstitial cystitis cancer cerebrovascular disorder neurodegenerative disease oligodendroglioma osteoporosis type 2 diabetes mellitus lung cancer pancreatic intraductal papillary-mucinous carcinoma malignant ependymoma pituitary tumor hyperglycemia astrocytic tumor hypoglycemia hypothyroidism inborn carbohydrate metabolic disorder breast disease myocardial ischemia Duchenne muscular dystrophy Sjogren syndrome invasive ductal breast carcinoma Emery-Dreifuss muscular dystrophy acute kidney failure osteogenesis imperfecta eye disease limb-girdle muscular dystrophy ovarian cancer lung carcinoma congenital diaphragmatic hernia pancreatic intraductal papillary-mucinous neoplasm alcohol abuse malignant glioma hepatocellular carcinoma pituitary cancer hyperinsulinism atopic eczema hypogonadism autoimmune disease psoriasis idiopathic interstitial pneumonia drug-induced liver injury intellectual disability ductal breast carcinoma in situ juvenile dermatomyositis Laron syndrome obesity disorder type 1 diabetes mellitus pancreatic ductal adenocarcinoma glioblastoma adrenal cortex carcinoma urinary bladder neoplasm lung disease pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia malignant mesothelioma Crohn's colitis delirium
B [auth E]	Pharos: P06213	Donohue syndrome type 2 diabetes mellitus hyperinsulinism due to INSR deficiency Rabson-Mendenhall syndrome Insulin Resistance Alzheimer disease glucose intolerance hyperinsulinism insulin-resistance syndrome type A polycystic ovary syndrome Parkinson disease diabetic autonomic neuropathy diabetic neuropathy congenital diaphragmatic hernia hyperglycemia Donohue syndrome type 2 diabetes mellitus hyperinsulinism due to INSR deficiency Rabson-Mendenhall syndrome Insulin Resistance Alzheimer disease glucose intolerance hyperinsulinism insulin-resistance syndrome type A polycystic ovary syndrome Parkinson disease diabetic autonomic neuropathy diabetic neuropathy congenital diaphragmatic hernia hyperglycemia diabetic polyneuropathy Lewy body dementia diabetes mellitus psoriasis spina bifida intellectual disability substance-related disorder lung disease acquired metabolic disease drug dependence malignant glioma maturity-onset diabetes of the young osteogenesis imperfecta glioblastoma pancreatic ductal adenocarcinoma hyperinsulinemic hypoglycemia hypertensive disorder substance dependence large cell medulloblastoma type 1 diabetes mellitus malignant mesothelioma esophageal adenocarcinoma osteosarcoma atypical teratoid rhabdoid tumor pancreatic intraductal papillary-mucinous neoplasm plasma cell myeloma dermatomyositis Sjogren syndrome hypothyroidism substance abuse malignant ependymoma malignant pancreatic neoplasm exocrine pancreatic carcinoma astrocytic tumor gastric adenocarcinoma ovarian cancer breast cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia
C [auth F]	Pharos: P08069	growth delay due to insulin-like growth factor I resistance Alzheimer disease adrenal cortex carcinoma peripheral nervous system disease respiratory failure Lewy body dementia skin cancer congenital diaphragmatic hernia endometrial carcinoma peripheral neuropathy atrial fibrillation juvenile idiopathic arthritis breast cancer skin neoplasm Parkinson disease growth delay due to insulin-like growth factor I resistance Alzheimer disease adrenal cortex carcinoma peripheral nervous system disease respiratory failure Lewy body dementia skin cancer congenital diaphragmatic hernia endometrial carcinoma peripheral neuropathy atrial fibrillation juvenile idiopathic arthritis breast cancer skin neoplasm Parkinson disease breast carcinoma lung disease malignant glioma Congenital hernia of foramen of Morgagni endometrial cancer non-small cell lung carcinoma endometriosis osteosarcoma pancreatic intraductal papillary-mucinous carcinoma adrenal carcinoma pilocytic astrocytoma intellectual disability primitive neuroectodermal tumor astrocytic tumor atypical teratoid rhabdoid tumor breast disease squamous cell lung carcinoma diabetes mellitus medulloblastoma oligodendroglioma ovarian cancer genetic endocrine growth disease pancreatic intraductal papillary-mucinous neoplasm acute myeloid leukemia inborn carbohydrate metabolic disorder interstitial cystitis progressive supranuclear palsy large cell medulloblastoma cancer malignant ependymoma endocrine exophthalmos osteogenesis imperfecta fetal growth restriction pancreatic ductal adenocarcinoma glioblastoma adenoma hepatocellular carcinoma Pick disease intervertebral disc degenerative disorder attention deficit hyperactivity disorder, inattentive type Laron syndrome Silver-Russell syndrome spina bifida