4XHT

Crystal structure of Timeless_PAB domain native form

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Timeless PAB domain-like	8046691	4005241	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PUG domain-like	8102998	3001501	SCOP2 (2022-06-29)
B [auth C]	SCOP2B Superfamily	PUG domain-like	8102998	3001501	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	PUG domain-like	8102998	3001501	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	PUG domain-like	8102998	3001501	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	TIMELESS_C	e4xhtA1	A: a+b two layers	X: R3H domain-like	H: PUB domain (From Topology)	T: PUB domain	F: TIMELESS_C	ECOD (1.6)
B [auth C]	TIMELESS_C	e4xhtC1	A: a+b two layers	X: R3H domain-like	H: PUB domain (From Topology)	T: PUB domain	F: TIMELESS_C	ECOD (1.6)
C [auth B]	TIMELESS_C	e4xhtB1	A: a+b two layers	X: R3H domain-like	H: PUB domain (From Topology)	T: PUB domain	F: TIMELESS_C	ECOD (1.6)
D	TIMELESS_C	e4xhtD1	A: a+b two layers	X: R3H domain-like	H: PUB domain (From Topology)	T: PUB domain	F: TIMELESS_C	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth C], C [auth B], D	PF05029	Timeless PAB domain (TIMELESS_C)	Timeless PAB domain	The timeless (tim) gene is essential for circadian function in Drosophila. Putative homologues of Drosophila tim have been identified in both mice and humans (mTim and hTIM, respectively). Mammalian TIM is not the true orthologue of Drosophila TIM, b ...	The timeless (tim) gene is essential for circadian function in Drosophila. Putative homologues of Drosophila tim have been identified in both mice and humans (mTim and hTIM, respectively). Mammalian TIM is not the true orthologue of Drosophila TIM, but is the likely orthologue of a fly gene, timeout (also called tim-2) [1]. mTim has been shown to be essential for embryonic development, but does not have substantiated circadian function[2]. This entry corresponds to the PAB (PARP-1-binding domain) [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C], C [auth B], D	Protein timeless homolog	DNA binding binding organic cyclic compound binding nucleic acid binding identical protein binding protein binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process regulation of double-strand break repair positive regulation of biological process regulation of cellular response to stress positive regulation of response to stimulus positive regulation of metabolic process positive regulation of DNA repair regulation of response to stress positive regulation of macromolecule metabolic process positive regulation of cellular process DNA repair double-strand break repair positive regulation of nucleobase-containing compound metabolic process DNA metabolic process positive regulation of double-strand break repair regulation of DNA repair positive regulation of DNA metabolic process regulation of response to stimulus regulation of DNA metabolic process rhythmic process circadian rhythm detection of stimulus response to abiotic stimulus detection of abiotic stimulus developmental process multicellular organismal process epithelium development tube development branching morphogenesis of an epithelial tube morphogenesis of an epithelium tissue development tissue morphogenesis anatomical structure morphogenesis multicellular organism development tube morphogenesis morphogenesis of a branching structure anatomical structure development epithelial tube morphogenesis morphogenesis of a branching epithelium regulation of circadian rhythm cell cycle phase transition cell cycle cell cycle process cell division cellular response to chemical stimulus response to chemical response to cisplatin cellular response to cisplatin animal organ development respiratory tube development lung development respiratory system development system development regulation of DNA recombination positive regulation of double-strand break repair via homologous recombination recombinational repair double-strand break repair via homologous recombination positive regulation of DNA recombination DNA recombination regulation of double-strand break repair via homologous recombination cellular response to nitrogen compound response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to bleomycin response to bleomycin regulation of cell cycle phase transition signaling negative regulation of cell cycle intracellular signal transduction cell communication negative regulation of cell cycle phase transition signal transduction DNA replication checkpoint signaling regulation of cell cycle regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling DNA-templated DNA replication maintenance of fidelity negative regulation of DNA-templated DNA replication DNA-templated DNA replication negative regulation of DNA replication DNA replication regulation of DNA-templated DNA replication replication fork arrest negative regulation of DNA metabolic process regulation of DNA replication cellular response to hydroxyurea response to hydroxyurea	membrane-bounded organelle replication fork protection complex protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear replication fork intracellular membraneless organelle nuclear chromosome chromosome intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle membrane-bounded organelle replication fork protection complex protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear replication fork intracellular membraneless organelle nuclear chromosome chromosome intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle replication fork nuclear lumen nucleoplasm chromatin site of double-strand break site of DNA damage

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth C], C [auth B], D	IPR007725	Timeless, C-terminal	Domain
A, B [auth C], C [auth B], D	IPR044998	Timeless	Family
A, B [auth C], C [auth B], D	IPR006906	Timeless, N-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B [auth C], C [auth B], D	Pharos: Q9UNS1	psoriasis nasopharyngeal carcinoma ovarian cancer skin disease adrenal cortex carcinoma bipolar disorder depressive disorder IgA glomerulonephritis lung adenocarcinoma malignant glioma Mental Depression non-small cell lung carcinoma primitive neuroectodermal tumor tuberculosis atopic eczema psoriasis nasopharyngeal carcinoma ovarian cancer skin disease adrenal cortex carcinoma bipolar disorder depressive disorder IgA glomerulonephritis lung adenocarcinoma malignant glioma Mental Depression non-small cell lung carcinoma primitive neuroectodermal tumor tuberculosis atopic eczema breast cancer ductal breast carcinoma in situ invasive ductal breast carcinoma lung cancer osteosarcoma atypical teratoid rhabdoid tumor breast carcinoma glioblastoma large cell medulloblastoma malignant colon neoplasm medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.