4QXX | pdb_00004qxx

Structure of the amyloid forming peptide GNLVS (residues 26-30) from the eosinophil major basic protein (EMBP)

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth Z]	Bone marrow proteoglycan	binding carbohydrate binding structural molecule activity extracellular matrix structural constituent extracellular matrix structural constituent conferring compression resistance heparin binding glycosaminoglycan binding carbohydrate derivative binding sulfur compound binding	response to stimulus immune response immune system process multicellular organismal process regulation of immune effector process regulation of cellular process negative regulation of biological process negative regulation of macrophage cytokine production cytokine production regulation of cytokine production negative regulation of cellular process regulation of immune system process regulation of multicellular organismal process myeloid leukocyte cytokine production response to stimulus immune response immune system process multicellular organismal process regulation of immune effector process regulation of cellular process negative regulation of biological process negative regulation of macrophage cytokine production cytokine production regulation of cytokine production negative regulation of cellular process regulation of immune system process regulation of multicellular organismal process myeloid leukocyte cytokine production cytokine production involved in immune response negative regulation of macromolecule metabolic process production of molecular mediator of immune response regulation of biosynthetic process negative regulation of cytokine production involved in immune response regulation of biological process regulation of cytokine production involved in immune response negative regulation of metabolic process biological regulation negative regulation of immune effector process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process immune effector process regulation of gene expression negative regulation of production of molecular mediator of immune response negative regulation of gene expression biosynthetic process regulation of macrophage cytokine production negative regulation of immune system process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of production of molecular mediator of immune response negative regulation of multicellular organismal process regulation of metabolic process macrophage cytokine production biological process involved in interspecies interaction between organisms response to other organism defense response defense response to nematode defense response to other organism response to stress response to external stimulus response to external biotic stimulus response to biotic stimulus regulation of interleukin-4 production positive regulation of biological process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process positive regulation of interleukin-4 production interleukin-4 production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production defense response to bacterium response to bacterium negative regulation of interleukin-10 production interleukin-10 production regulation of interleukin-10 production	cellular anatomical structure extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cellular anatomical structure extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure transport vesicle intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle cytoplasm membrane-enclosed lumen ficolin-1-rich granule intracellular organelle lumen organelle lumen ficolin-1-rich granule lumen secretory granule secretory vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth Z]	IPR002352	Eosinophil major basic protein	Family
A [auth Z]	IPR033816	Eosinophil major basic protein, C-type lectin-like domain	Domain
A [auth Z]	IPR016187	C-type lectin fold	Homologous Superfamily
A [auth Z]	IPR001304	C-type lectin-like	Domain
A [auth Z]	IPR018378	C-type lectin, conserved site	Conserved Site
A [auth Z]	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
A [auth Z]	IPR050111	C-type lectin and snaclec domain-containing protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth Z]	Pharos: P13727	colorectal cancer Crohn disease Hodgkins lymphoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.