Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyActivating enzymes of the ubiquitin-like proteins 8003540 3000112 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyActivating enzymes of the ubiquitin-like proteins 8017546 3000112 SCOP2B (2022-06-29)
ASCOP2B SuperfamilySCCH domain-like 8003543 3000139 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyFCCH domain-like 8003532 3000138 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyCC (catalytic cysteine) domain-like 8003552 3000140 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyE2 binding domain-like 8003942 3000147 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyActivating enzymes of the ubiquitin-like proteins 8003540 3000112 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyActivating enzymes of the ubiquitin-like proteins 8017546 3000112 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyE2 binding domain-like 8003942 3000147 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyFCCH domain-like 8003532 3000138 SCOP2B (2022-06-29)
CSCOP2B SuperfamilySCCH domain-like 8003543 3000139 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyCC (catalytic cysteine) domain-like 8003552 3000140 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyUbiquitin-like 8040187 3000157 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyUbiquitin-like 8040187 3000157 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyUbiquitin-like 8040187 3000157 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AE1_FCCHe4nnjA3 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: E1_FCCHECOD (1.6)
AUBA_e1_thiolCyse4nnjA4 A: alpha arraysX: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)H: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)T: Catalytic cysteine domain in ubiquitin-activating enzymeF: UBA_e1_thiolCysECOD (1.6)
AThiF_3e4nnjA2 A: alpha arraysX: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)H: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)T: Catalytic cysteine domain in ubiquitin-activating enzymeF: ThiF_3ECOD (1.6)
AE1_UFDe4nnjA1 A: a+b two layersX: beta-GraspH: E2-binding domain of E1 (From Topology)T: E2-binding domain of E1F: E1_UFDECOD (1.6)
AThiF_1e4nnjA6 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: Activating enzymes of the ubiquitin-like proteinsF: ThiF_1ECOD (1.6)
AThiF_3e4nnjA5 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: Activating enzymes of the ubiquitin-like proteinsF: ThiF_3ECOD (1.6)
CE1_FCCHe4nnjC3 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: E1_FCCHECOD (1.6)
CUBA_e1_thiolCyse4nnjC1 A: alpha arraysX: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)H: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)T: Catalytic cysteine domain in ubiquitin-activating enzymeF: UBA_e1_thiolCysECOD (1.6)
CThiF_3e4nnjC6 A: alpha arraysX: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)H: Catalytic cysteine domain in ubiquitin-activating enzyme (From Topology)T: Catalytic cysteine domain in ubiquitin-activating enzymeF: ThiF_3ECOD (1.6)
CE1_UFDe4nnjC4 A: a+b two layersX: beta-GraspH: E2-binding domain of E1 (From Topology)T: E2-binding domain of E1F: E1_UFDECOD (1.6)
CThiF_1e4nnjC7 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: Activating enzymes of the ubiquitin-like proteinsF: ThiF_1ECOD (1.6)
CThiF_3e4nnjC5 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: Activating enzymes of the ubiquitin-like proteinsF: ThiF_3ECOD (1.6)
Bubiquitin_1e4nnjB1 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: ubiquitin_1ECOD (1.6)
Dubiquitin_1e4nnjD1 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: ubiquitin_1ECOD (1.6)
Eubiquitin_1e4nnjE1 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: ubiquitin_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.50.50.80 Alpha Beta 3-Layer(bba) Sandwich FAD/NAD(P)-binding domain Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1CATH (4.3.0)
A3.40.50.12550 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2CATH (4.3.0)
A2.40.30.180 Mainly Beta Beta Barrel Elongation Factor Tu (Ef-tu) domain 3CATH (4.3.0)
A3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like DomainCATH (4.3.0)
A1.10.10.2660 Mainly Alpha Orthogonal Bundle Arc Repressor Mutant, subunit A Ubiquitin-activating enzyme E1, SCCH domainCATH (4.3.0)
A3.10.290.60 Alpha Beta Roll Structural Genomics Hypothetical 15.5 Kd Protein In mrcA-pckA Intergenic Region Chain ACATH (4.3.0)
C3.50.50.80 Alpha Beta 3-Layer(bba) Sandwich FAD/NAD(P)-binding domain Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1CATH (4.3.0)
C3.40.50.12550 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2CATH (4.3.0)
C2.40.30.180 Mainly Beta Beta Barrel Elongation Factor Tu (Ef-tu) domain 3CATH (4.3.0)
C3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like DomainCATH (4.3.0)
C1.10.10.2660 Mainly Alpha Orthogonal Bundle Arc Repressor Mutant, subunit A Ubiquitin-activating enzyme E1, SCCH domainCATH (4.3.0)
C3.10.290.60 Alpha Beta Roll Structural Genomics Hypothetical 15.5 Kd Protein In mrcA-pckA Intergenic Region Chain ACATH (4.3.0)
B3.10.20.90 Alpha Beta Roll Ubiquitin-like (UB roll) Phosphatidylinositol 3-kinase Catalytic SubunitCATH (4.3.0)
D3.10.20.90 Alpha Beta Roll Ubiquitin-like (UB roll) Phosphatidylinositol 3-kinase Catalytic SubunitCATH (4.3.0)
E3.10.20.90 Alpha Beta Roll Ubiquitin-like (UB roll) Phosphatidylinositol 3-kinase Catalytic SubunitCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, C
PF00899ThiF family (ThiF)ThiF familyThis domain is found in ubiquitin activating E1 family and members of the bacterial ThiF/MoeB/HesA family. It is repeated in Ubiquitin-activating enzyme E1 [1-3].Domain
A, C
PF10585Ubiquitin-activating enzyme, SCCH domain (UBA_E1_SCCH)Ubiquitin-activating enzyme, SCCH domainUbiquitin-activating enzyme (E1 enzyme) activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thiolester and free A ...Domain
A, C
PF09358Ubiquitin fold domain (E1_UFD)Ubiquitin fold domainThe ubiquitin fold domain is found at the C-terminus of ubiquitin-activating E1 family enzymes. This domain binds to E2 enzymes [1].Domain
A, C
PF16190Ubiquitin-activating enzyme E1 FCCH domain (E1_FCCH)Ubiquitin-activating enzyme E1 FCCH domainThis domain is found in the ubiquitin-activating E1 family enzymes [1].Domain
A, C
PF16191Ubiquitin-activating enzyme E1 four-helix bundle (E1_4HB)Ubiquitin-activating enzyme E1 four-helix bundleThis domain is found in the ubiquitin-activating E1 family enzymes [1].Domain
B, D, E
PF00240Ubiquitin family (ubiquitin)Ubiquitin familyThis family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry ...Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C
Ubiquitin-activating enzyme E1 1
B, D, E
Uba1