4MRH

Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4mrha1	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	Link domain	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d4mrha2	Artifacts	Tags	Tags	Tags	N-terminal Tags	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	C-type lectin-like	8077765	3001261	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Xlink	e4mrhA1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Xlink	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00193	Extracellular link domain (Xlink)	Extracellular link domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CD44 antigen	cargo receptor activity transforming growth factor beta receptor binding protein binding binding type II transforming growth factor beta receptor binding signaling receptor binding cytokine receptor binding channel regulator activity molecular function regulator activity transporter regulator activity glycosaminoglycan binding carbohydrate derivative binding hyaluronic acid binding	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular response to cytokine stimulus cellular process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular response to cytokine stimulus cellular process signal transduction positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette positive regulation of cellular process regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling immune response regulation of adaptive immune response adaptive immune response positive regulation of immune response immune system process regulation of immune response regulation of immune system process positive regulation of adaptive immune response positive regulation of immune system process regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process multicellular organismal process regulation of B cell apoptotic process homeostatic process leukocyte apoptotic process negative regulation of biological process regulation of programmed cell death lymphocyte apoptotic process negative regulation of leukocyte apoptotic process negative regulation of mature B cell apoptotic process negative regulation of cellular process regulation of leukocyte apoptotic process regulation of lymphocyte apoptotic process mature B cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process B cell apoptotic process cell death negative regulation of B cell apoptotic process B cell homeostasis negative regulation of apoptotic process multicellular organismal-level homeostasis leukocyte homeostasis homeostasis of number of cells regulation of mature B cell apoptotic process lymphocyte homeostasis apoptotic process programmed cell death negative regulation of lymphocyte apoptotic process negative regulation of signaling negative regulation of intracellular signal transduction regulation of cellular response to stress DNA damage response, signal transduction by p53 class mediator negative regulation of cell communication cellular response to stress response to stress regulation of response to stress regulation of signal transduction by p53 class mediator negative regulation of DNA damage response, signal transduction by p53 class mediator regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of signal transduction by p53 class mediator negative regulation of response to stimulus signal transduction by p53 class mediator negative regulation of signal transduction DNA damage response signal transduction in response to DNA damage regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response defense response response to external stimulus regulation of inflammatory response negative regulation of response to external stimulus negative regulation of defense response inflammatory response regulation of cellular component organization regulation of developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell morphogenesis regulation of cell morphogenesis cellular component organization cell projection morphogenesis regulation of lamellipodium organization anatomical structure development regulation of lamellipodium morphogenesis cellular component organization or biogenesis regulation of anatomical structure morphogenesis developmental process plasma membrane bounded cell projection organization regulation of cell projection organization anatomical structure morphogenesis lamellipodium organization lamellipodium morphogenesis regulation of plasma membrane bounded cell projection organization regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway by p53 class mediator regulation of apoptotic signaling pathway regulation of intrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of intrinsic apoptotic signaling pathway by p53 class mediator wound healing wound healing involved in inflammatory response inflammatory response to wounding response to wounding prostate gland development reproductive process gland development developmental process involved in reproduction prostate gland epithelium morphogenesis multicellular organism development gland morphogenesis reproductive structure development animal organ morphogenesis system development epithelium development reproductive system development animal organ development morphogenesis of an epithelium urogenital system development tissue development prostate gland morphogenesis tissue morphogenesis morphogenesis of a branching structure branching involved in prostate gland morphogenesis morphogenesis of a branching epithelium cell adhesion Wnt signaling pathway negative regulation of lymphocyte proliferation regulation of alpha-beta T cell activation regulation of leukocyte activation regulation of cell activation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation alpha-beta T cell proliferation T cell activation lymphocyte proliferation alpha-beta T cell activation regulation of leukocyte proliferation cell population proliferation regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion mononuclear cell proliferation regulation of cell population proliferation negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process negative regulation of leukocyte activation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation negative regulation of mononuclear cell proliferation regulation of alpha-beta T cell proliferation cell-cell adhesion CD4-positive, alpha-beta T cell activation regulation of multicellular organismal process regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation CD4-positive, alpha-beta T cell proliferation negative regulation of cell population proliferation regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation regulation of T cell proliferation negative regulation of alpha-beta T cell proliferation regulation of CD4-positive, alpha-beta T cell activation negative regulation of immune system process negative regulation of CD4-positive, alpha-beta T cell proliferation regulation of mononuclear cell proliferation negative regulation of alpha-beta T cell activation regulation of lymphocyte activation epiboly involved in wound healing morphogenesis of an epithelial sheet epiboly cell migration wound healing, spreading of cells cell motility mesonephric epithelium development kidney epithelium development nephron morphogenesis branching morphogenesis of an epithelial tube nephron tubule morphogenesis nephron epithelium morphogenesis nephron tubule development renal system development ureteric bud morphogenesis tube morphogenesis branching involved in ureteric bud morphogenesis renal tubule development epithelial tube morphogenesis nephron development nephron epithelium development ureteric bud development tube development mesonephros development kidney morphogenesis mesonephric tubule morphogenesis kidney development mesonephric tubule development renal tubule morphogenesis mucopolysaccharide metabolic process carbohydrate derivative catabolic process catabolic process hyaluronan catabolic process glycosaminoglycan metabolic process carbohydrate derivative metabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process hyaluronan metabolic process aminoglycan metabolic process regulation of leukocyte differentiation mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation regulation of cell development negative regulation of T cell differentiation cell differentiation T cell differentiation negative regulation of hemopoiesis negative regulation of leukocyte differentiation negative regulation of lymphocyte differentiation leukocyte differentiation cellular developmental process cell development regulation of T cell differentiation negative regulation of regulatory T cell differentiation negative regulation of cell differentiation regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis negative regulation of developmental process regulation of regulatory T cell differentiation negative regulation of cell development regulatory T cell differentiation regulation of hemopoiesis localization import into cell transport receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane apical part of cell plasma membrane region apical plasma membrane basal part of cell basal plasma membrane basolateral plasma membrane membrane microdomain cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane apical part of cell plasma membrane region apical plasma membrane basal part of cell basal plasma membrane basolateral plasma membrane membrane microdomain membrane raft protein-containing complex macrophage migration inhibitory factor receptor complex receptor complex cell leading edge leading edge membrane plasma membrane bounded cell projection cell projection lamellipodium membrane cell projection membrane lamellipodium extracellular region actin-based cell projection microvillus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001231	CD44 antigen	Family
A	IPR016187	C-type lectin fold	Homologous Superfamily
A	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
A	IPR000538	Link domain	Domain
A	IPR043210	CD44 antigen-like	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.