4KFJ
Human dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5-(isoquin-5-yl)phenyl]prop-1-yn-1-yl}6-ethylprimidine-2,4-diamine
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | d4kfjb_ | Alpha and beta proteins (a/b) | Dihydrofolate reductase-like | Dihydrofolate reductase-like | Dihydrofolate reductases | Dihydrofolate reductases, eukaryotic type | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
A | d4kfja_ | Alpha and beta proteins (a/b) | Dihydrofolate reductase-like | Dihydrofolate reductase-like | Dihydrofolate reductases | Dihydrofolate reductases, eukaryotic type | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | DHFR_1 | e4kfjB1 | A: a/b three-layered sandwiches | X: Dihydrofolate reductases (From Topology) | H: Dihydrofolate reductases (From Topology) | T: Dihydrofolate reductases | F: DHFR_1 | ECOD (1.6) |
A | DHFR_1 | e4kfjA1 | A: a/b three-layered sandwiches | X: Dihydrofolate reductases (From Topology) | H: Dihydrofolate reductases (From Topology) | T: Dihydrofolate reductases | F: DHFR_1 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B | 3.40.430.10 | Alpha Beta | 3-Layer(aba) Sandwich | Dihydrofolate Reductase, subunit A | Dihydrofolate Reductase, subunit A | CATH (4.3.0) |
A | 3.40.430.10 | Alpha Beta | 3-Layer(aba) Sandwich | Dihydrofolate Reductase, subunit A | Dihydrofolate Reductase, subunit A | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00186 | Dihydrofolate reductase (DHFR_1) | Dihydrofolate reductase | - | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR017925 | Dihydrofolate reductase conserved site | Conserved Site | |
IPR012259 | Dihydrofolate reductase | Family | |
IPR024072 | Dihydrofolate reductase-like domain superfamily | Homologous Superfamily | |
IPR001796 | Dihydrofolate reductase domain | Domain |