4GRW
Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs)
External Resource: Annotation
- Domain Annotation: SCOP/SCOPe Classification
- Domain Annotation: SCOP2 Classification
- Domain Annotation: ECOD Classification
- Domain Annotation: CATH
- IMGT Antibody Annotation
- SAbDab Antibody Annotation
- Protein Family Annotation
- Gene Ontology: Gene Product Annotation
- InterPro: Protein Family Classification
- Pharos: Disease Associations
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
B | SCOP2B Superfamily | Fibronectin type III | 8055151 | 3002063 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Fibronectin type III | 8055537 | 3002063 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Immunoglobulin (Ig) domain-like | 8054841 | 3000071 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Fibronectin type III | 8055537 | 3002063 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Immunoglobulin (Ig) domain-like | 8054841 | 3000071 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Fibronectin type III | 8055151 | 3002063 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | IL12p40_C | e4grwB7 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: IL12p40_C | ECOD (1.6) |
B | Ig_5 | e4grwB8 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: Ig_5 | ECOD (1.6) |
B | fn3_6 | e4grwB9 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: fn3_6 | ECOD (1.6) |
D | IL12p40_C | e4grwD1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: IL12p40_C | ECOD (1.6) |
D | Ig_5 | e4grwD2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: Ig_5 | ECOD (1.6) |
D | fn3_6 | e4grwD3 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: fn3_6 | ECOD (1.6) |
E | V-set_12 | e4grwE1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_12 | ECOD (1.6) |
G | V-set_12 | e4grwG1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_12 | ECOD (1.6) |
F | V-set_12 | e4grwF1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_12 | ECOD (1.6) |
J | V-set_12 | e4grwJ1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_12 | ECOD (1.6) |
I | V-set_8 | e4grwI1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
H | V-set_8 | e4grwH1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
A | IL6 | e4grwA3 | A: alpha bundles | X: Ferritin/Heme oxygenase/4-helical cytokines | H: 4-helical cytokines (From Topology) | T: 4-helical cytokines | F: IL6 | ECOD (1.6) |
C | IL6 | e4grwC1 | A: alpha bundles | X: Ferritin/Heme oxygenase/4-helical cytokines | H: 4-helical cytokines (From Topology) | T: 4-helical cytokines | F: IL6 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
D | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
E | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
G | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
F | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
J | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
I | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
H | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
A | 1.20.1250.10 | Mainly Alpha | Up-down Bundle | Growth Hormone | Chain: A | CATH (4.3.0) |
C | 1.20.1250.10 | Mainly Alpha | Up-down Bundle | Growth Hormone | Chain: A | CATH (4.3.0) |
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
Interleukin-12 subunit beta | B2M | Homo sapiens (human) | IL12B*01 | C-LIKE-DOMAIN C-LIKE | RPI | B2M | IMGT (202447-0) | |
Nanobody 124C4 | VH | Lama glama (llama) | IGHV3S1*01, IGHV3S2*01, IGHJ3*01 | V-DOMAIN VH | IG | (VH) | IMGT (202447-0) | |
Nanobody 37D5 | VH | Lama glama (llama) | IGHV3S1*01, IGHJ4*01 | V-DOMAIN VH | IG | (VH) | IMGT (202447-0) | |
Nanobody 22E11 | VH | Lama glama (llama) | IGHV3S3*01, IGHJ4*01 | V-DOMAIN VH | IG | (VH) | IMGT (202447-0) |
SAbDab Antibody Annotation SAbDab Database Homepage
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
---|---|---|---|---|---|
Heavy Chain | IGHV1 | - | interleukin-12 subunit beta | SAbDab (2024-11-29) | |
Heavy Chain | IGHV1 | - | interleukin-23 subunit alpha | SAbDab (2024-11-29) | |
Heavy Chain | IGHV1 | - | interleukin-12 subunit beta | SAbDab (2024-11-29) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF10420 | Cytokine interleukin-12p40 C-terminus (IL12p40_C) | Cytokine interleukin-12p40 C-terminus | IL12p40_C is the largely beta stranded C-terminal, D3, domain of interleukin-12p40 or interleukin-12B. This interleukin is produced on stimulation by macrophage-engulfed micro-organisms and other stimuli, when it dimerises with interleukin-12p35 to f ... | Domain | |
PF16649 | Interleukin 23 subunit alpha (IL23) | Interleukin 23 subunit alpha | This family, interleukin 23 subunit alpha, is a heterodimer consisting of a 40 kDa subunit - p40 - that is shared with IL12 and a unique 19 kDa subunit - p19. IL23 is a pro-inflammatory cytokine that binds to adnectins and thus plays a key role in th ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR036179 | Immunoglobulin-like domain superfamily | Homologous Superfamily | |
IPR003530 | Long hematopoietin receptor, soluble alpha chain, conserved site | Conserved Site | |
IPR013783 | Immunoglobulin-like fold | Homologous Superfamily | |
IPR007110 | Immunoglobulin-like domain | Domain | |
IPR003598 | Immunoglobulin subtype 2 | Domain | |
IPR050676 | Interleukin-12 | Family | |
IPR019482 | Interleukin-12 beta, central domain | Domain | |
IPR015528 | Interleukin-12 beta | Family | |
IPR003961 | Fibronectin type III | Domain | |
IPR036116 | Fibronectin type III superfamily | Homologous Superfamily | |
IPR009079 | Four-helical cytokine-like, core | Homologous Superfamily | |
IPR010831 | Interleukin-23 alpha | Family |