Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyFibronectin type III 8055151 3002063 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyFibronectin type III 8055537 3002063 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyImmunoglobulin (Ig) domain-like 8054841 3000071 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyFibronectin type III 8055537 3002063 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyImmunoglobulin (Ig) domain-like 8054841 3000071 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyFibronectin type III 8055151 3002063 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
BIL12p40_Ce4grwB7 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: IL12p40_CECOD (1.6)
BIg_5e4grwB8 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: Ig_5ECOD (1.6)
Bfn3_6e4grwB9 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: fn3_6ECOD (1.6)
DIL12p40_Ce4grwD1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: IL12p40_CECOD (1.6)
DIg_5e4grwD2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: Ig_5ECOD (1.6)
Dfn3_6e4grwD3 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: fn3_6ECOD (1.6)
EV-set_12e4grwE1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_12ECOD (1.6)
GV-set_12e4grwG1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_12ECOD (1.6)
FV-set_12e4grwF1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_12ECOD (1.6)
JV-set_12e4grwJ1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_12ECOD (1.6)
IV-set_8e4grwI1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
HV-set_8e4grwH1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
AIL6e4grwA3 A: alpha bundlesX: Ferritin/Heme oxygenase/4-helical cytokinesH: 4-helical cytokines (From Topology)T: 4-helical cytokinesF: IL6ECOD (1.6)
CIL6e4grwC1 A: alpha bundlesX: Ferritin/Heme oxygenase/4-helical cytokinesH: 4-helical cytokines (From Topology)T: 4-helical cytokinesF: IL6ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
B, D
Interleukin-12 subunit beta B2M Homo sapiens (human) IL12B*01 C-LIKE-DOMAIN C-LIKE RPI B2M IMGT (202447-0)
E, G
Nanobody 124C4 VH Lama glama (llama) IGHV3S1*01, IGHV3S2*01, IGHJ3*01 V-DOMAIN VH IG (VH) IMGT (202447-0)
F, J
Nanobody 37D5 VH Lama glama (llama) IGHV3S1*01, IGHJ4*01 V-DOMAIN VH IG (VH) IMGT (202447-0)
H, I
Nanobody 22E11 VH Lama glama (llama) IGHV3S3*01, IGHJ4*01 V-DOMAIN VH IG (VH) IMGT (202447-0)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
E, G
Heavy ChainIGHV1 -interleukin-12 subunit betaSAbDab (2024-11-29)
F, J
Heavy ChainIGHV1 -interleukin-23 subunit alphaSAbDab (2024-11-29)
H, I
Heavy ChainIGHV1 -interleukin-12 subunit betaSAbDab (2024-11-29)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
B, D
PF10420Cytokine interleukin-12p40 C-terminus (IL12p40_C)Cytokine interleukin-12p40 C-terminusIL12p40_C is the largely beta stranded C-terminal, D3, domain of interleukin-12p40 or interleukin-12B. This interleukin is produced on stimulation by macrophage-engulfed micro-organisms and other stimuli, when it dimerises with interleukin-12p35 to f ...IL12p40_C is the largely beta stranded C-terminal, D3, domain of interleukin-12p40 or interleukin-12B. This interleukin is produced on stimulation by macrophage-engulfed micro-organisms and other stimuli, when it dimerises with interleukin-12p35 to form a heterodimer which then binds to receptors on natural killer cells to activate them to destroy the micro-organisms [1]. This domain contains two disulfide bridges, one of which serves to bind p40 to p35 and the other to hold the beta strands within the domain together. The cupped shape of the p35 binding interface matches the elbow-like bend between D2 and D3 in p40 [2]. The domain is often associated with family fn3, Pfam:PF00041.
Domain
A, C
PF16649Interleukin 23 subunit alpha (IL23)Interleukin 23 subunit alphaThis family, interleukin 23 subunit alpha, is a heterodimer consisting of a 40 kDa subunit - p40 - that is shared with IL12 and a unique 19 kDa subunit - p19. IL23 is a pro-inflammatory cytokine that binds to adnectins and thus plays a key role in th ...This family, interleukin 23 subunit alpha, is a heterodimer consisting of a 40 kDa subunit - p40 - that is shared with IL12 and a unique 19 kDa subunit - p19. IL23 is a pro-inflammatory cytokine that binds to adnectins and thus plays a key role in the pathogenesis of several autoimmune and inflammatory diseases. IL23 signalling on the cell membrane works through the interaction of four proteins, two of which are shared with the IL12-receptor complex; signalling through the cell membrane involves the combined aggregation of at least two receptor components and then the subsequent activation of the Jak/Tyk tyrosine kinases and the family of STAT transcription factors [1,2,3].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
B, D
Interleukin-12 subunit beta
E, G
Nanobody 124C4---
F, J
Nanobody 37D5---
H, I
Nanobody 22E11---
A, C
Interleukin-23 subunit alpha