Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilySH2 domain 8035661 3000197 SCOP2B (2022-06-29)
ASCOP2B SuperfamilySH3-domain 8041589 3000153 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyProtein kinase-like (PK-like) 8036656 3000066 SCOP2B (2022-06-29)
BSCOP2B SuperfamilySH3-domain 8041589 3000153 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyProtein kinase-like (PK-like) 8036656 3000066 SCOP2B (2022-06-29)
BSCOP2B SuperfamilySH2 domain 8035661 3000197 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ASH3_1e3vs2A1 A: beta barrelsX: SH3H: SH3T: SH3F: SH3_1ECOD (1.6)
ASH2e3vs2A2 A: a+b two layersX: SH2 (From Topology)H: SH2 (From Topology)T: SH2F: SH2ECOD (1.6)
APkinase_Tyre3vs2A3 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
BSH3_1e3vs2B1 A: beta barrelsX: SH3H: SH3T: SH3F: SH3_1ECOD (1.6)
BSH2e3vs2B2 A: a+b two layersX: SH2 (From Topology)H: SH2 (From Topology)T: SH2F: SH2ECOD (1.6)
BPkinase_Tyre3vs2B3 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF00017SH2 domain (SH2)SH2 domain- Domain
A, B
PF00018SH3 domain (SH3_1)SH3 domainSH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.Domain
A, B
PF07714Protein tyrosine and serine/threonine kinase (PK_Tyr_Ser-Thr)Protein tyrosine and serine/threonine kinaseProtein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosph ...Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Tyrosine-protein kinase HCK

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
A, B
PTR Parent Component: TYR

RESIDAA0039

PSI-MOD :  O4'-phospho-L-tyrosine MOD:00048