3TPL
APO Structure of BACE1
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Asp_C_1 | e3tplA2 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: acid protease | F: Asp_C_1 | ECOD (1.6) |
A | Asp_N | e3tplA3 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: acid protease | F: Asp_N | ECOD (1.6) |
C | Asp_C_1 | e3tplC2 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: acid protease | F: Asp_C_1 | ECOD (1.6) |
C | Asp_N | e3tplC3 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: acid protease | F: Asp_N | ECOD (1.6) |
B | Asp_C_1 | e3tplB2 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: acid protease | F: Asp_C_1 | ECOD (1.6) |
B | Asp_N | e3tplB3 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: acid protease | F: Asp_N | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 2.40.70.10 | Mainly Beta | Beta Barrel | Cathepsin D, subunit A | domain 1 | CATH (4.3.0) |
C | 2.40.70.10 | Mainly Beta | Beta Barrel | Cathepsin D, subunit A | domain 1 | CATH (4.3.0) |
B | 2.40.70.10 | Mainly Beta | Beta Barrel | Cathepsin D, subunit A | domain 1 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00026 | Eukaryotic aspartyl protease (Asp) | Eukaryotic aspartyl protease | - | Family |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR009120 | Beta-secretase BACE1 | Family | |
IPR033121 | Peptidase family A1 domain | Domain | |
IPR033874 | Memapsin-like | Domain | |
IPR001461 | Aspartic peptidase A1 | Family | |
IPR009119 | Beta-secretase BACE | Family | |
IPR021109 | Aspartic peptidase domain superfamily | Homologous Superfamily | |
IPR001969 | Aspartic peptidase, active site | Active Site |