Annotations: 2Y38

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Laminin_N	e2y38A1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: Laminin_N	ECOD (1.6)
A	Laminin_EGF_1	e2y38A2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF_1	ECOD (1.6)
A	Laminin_EGF_2	e2y38A3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)
A	2.10.25.10	Mainly Beta	Ribbon	Laminin	Laminin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00053	Laminin EGF domain (EGF_laminin)	Laminin EGF domain	This family is like Pfam:PF00008 but has 8 conserved cysteines instead of six.	Domain
A	PF00055	Laminin N-terminal (Domain VI) (Laminin_N)	Laminin N-terminal (Domain VI)		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	LAMININ SUBUNIT ALPHA-5	cell adhesion molecule binding protein-containing complex binding protein binding binding integrin binding signaling receptor binding	regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation cellular process developmental process anatomical structure morphogenesis anatomical structure development animal organ development animal organ morphogenesis multicellular organismal process epithelium development tube development regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation cellular process developmental process anatomical structure morphogenesis anatomical structure development animal organ development animal organ morphogenesis multicellular organismal process epithelium development tube development branching morphogenesis of an epithelial tube morphogenesis of an epithelium tissue development tissue morphogenesis multicellular organism development tube morphogenesis morphogenesis of a branching structure epithelial tube morphogenesis morphogenesis of a branching epithelium odontogenesis of dentin-containing tooth odontogenesis substrate adhesion-dependent cell spreading cell-substrate adhesion cellular response to stimulus integrin-mediated signaling pathway cell surface receptor signaling pathway response to stimulus signaling cell communication signal transduction respiratory tube development lung development respiratory system development system development epidermis development molting cycle process hair cycle skin development skin epidermis development hair follicle development molting cycle hair cycle process muscle structure development muscle organ development protein localization localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane stem cell development neural crest cell differentiation cellular developmental process neural crest cell development cell development mesenchyme development mesenchymal cell migration stem cell differentiation cell differentiation ameboidal-type cell migration cell migration mesenchymal cell differentiation cell motility neural crest cell migration cellular component organization cell junction organization postsynapse organization synapse organization cellular component organization or biogenesis regulation of cell motility regulation of locomotion regulation of cell migration locomotion organelle assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis organelle organization cellular component assembly cilium assembly cilium organization cell projection assembly morphogenesis of embryonic epithelium embryonic morphogenesis embryo development morphogenesis of a polarized epithelium blastoderm segmentation segmentation pattern specification process embryonic pattern specification regionalization trunk neural crest cell migration trunk segmentation cell population proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation skeletal system development skeletal system morphogenesis regulation of embryonic development regulation of multicellular organismal development regulation of developmental process regulation of multicellular organismal process gland development branching involved in salivary gland morphogenesis salivary gland development gland morphogenesis salivary gland morphogenesis exocrine system development mesonephric epithelium development kidney epithelium development nephron morphogenesis nephron tubule morphogenesis nephron epithelium morphogenesis nephron tubule development renal system development ureteric bud morphogenesis branching involved in ureteric bud morphogenesis renal tubule development nephron development nephron epithelium development ureteric bud development mesonephros development kidney morphogenesis mesonephric tubule morphogenesis kidney development mesonephric tubule development renal tubule morphogenesis	basement membrane cell periphery extracellular matrix cellular anatomical structure external encapsulating structure laminin complex laminin-5 complex protein-containing complex collagen-containing extracellular matrix laminin-10 complex synaptic cleft extracellular region synapse cell junction basement membrane cell periphery extracellular matrix cellular anatomical structure external encapsulating structure laminin complex laminin-5 complex protein-containing complex collagen-containing extracellular matrix laminin-10 complex synaptic cleft extracellular region synapse cell junction glutamatergic synapse neuromuscular junction synapse-associated extracellular matrix extracellular matrix of synaptic cleft specialized extracellular matrix extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR008211	Laminin, N-terminal	Domain
A	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A	IPR002049	Laminin-type EGF domain	Domain
A	IPR010307	Laminin domain II	Domain
A	IPR000742	EGF-like domain	Domain
A	IPR001791	Laminin G domain	Domain
A	IPR009254	Laminin alpha, domain I	Domain
A	IPR050440	Laminin/Netrin Extracellular Matrix	Family
A	IPR000034	Laminin IV	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.