2QP8
Structure of BACE Bound to SCH734723
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | d2qp8b_ | All beta proteins | Acid proteases | Acid proteases | Pepsin-like | beta-secretase (memapsin) | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
A | d2qp8a_ | All beta proteins | Acid proteases | Acid proteases | Pepsin-like | beta-secretase (memapsin) | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | Asp_C_1 | e2qp8B2 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: acid protease | F: Asp_C_1 | ECOD (1.6) |
B | Asp_N | e2qp8B3 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: acid protease | F: Asp_N | ECOD (1.6) |
A | Asp_C_1 | e2qp8A2 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: acid protease | F: Asp_C_1 | ECOD (1.6) |
A | Asp_N | e2qp8A3 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: acid protease | F: Asp_N | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B | 2.40.70.10 | Mainly Beta | Beta Barrel | Cathepsin D, subunit A | domain 1 | CATH (4.3.0) |
A | 2.40.70.10 | Mainly Beta | Beta Barrel | Cathepsin D, subunit A | domain 1 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00026 | Eukaryotic aspartyl protease (Asp) | Eukaryotic aspartyl protease | - | Family |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR009120 | Beta-secretase BACE1 | Family | |
IPR033121 | Peptidase family A1 domain | Domain | |
IPR033874 | Memapsin-like | Domain | |
IPR001461 | Aspartic peptidase A1 | Family | |
IPR009119 | Beta-secretase BACE | Family | |
IPR021109 | Aspartic peptidase domain superfamily | Homologous Superfamily | |
IPR001969 | Aspartic peptidase, active site | Active Site |