2NLA
Crystal structure of the Mcl-1:mNoxaB BH3 complex
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d2nlaa_ | Membrane and cell surface proteins and peptides | Toxins' membrane translocation domains | Bcl-2 inhibitors of programmed cell death | Bcl-2 inhibitors of programmed cell death | EAT/MCL-1 (Myeloid cell leukemia sequence 1) | mouse (Mus musculus ) [TaxId: 10090 ], human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Bcl-2 | e2nlaA1 | A: alpha arrays | X: Toxins' membrane translocation domains | H: Bcl-2 inhibitors of programmed cell death (From Topology) | T: Bcl-2 inhibitors of programmed cell death | F: Bcl-2 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 1.10.437.10 | Mainly Alpha | Orthogonal Bundle | Apoptosis Regulator Bcl-x | Blc2-like | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00452 | Apoptosis regulator proteins, Bcl-2 family (Bcl-2) | Apoptosis regulator proteins, Bcl-2 family | - | Family |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR024140 | Phorbol-12-myristate-13-acetate-induced protein 1 | Family | |
IPR020726 | Apoptosis regulator, Bcl-2, BH2 motif, conserved site | Conserved Site | |
IPR036834 | Bcl-2-like superfamily | Homologous Superfamily | |
IPR046371 | Bcl-2, Bcl-2 homology region 1-3 | Domain | |
IPR002475 | Bcl2-like | Family | |
IPR026298 | Bcl-2 family | Family | |
IPR020717 | Apoptosis regulator, Bcl-2, BH1 motif, conserved site | Conserved Site | |
IPR013281 | Apoptosis regulator, Mcl-1 | Family | |
IPR020728 | Apoptosis regulator, Bcl-2, BH3 motif, conserved site | Conserved Site | |
IPR020726 | Apoptosis regulator, Bcl-2, BH2 motif, conserved site | Conserved Site | |
IPR036834 | Bcl-2-like superfamily | Homologous Superfamily | |
IPR046371 | Bcl-2, Bcl-2 homology region 1-3 | Domain | |
IPR002475 | Bcl2-like | Family | |
IPR026298 | Bcl-2 family | Family | |
IPR020717 | Apoptosis regulator, Bcl-2, BH1 motif, conserved site | Conserved Site | |
IPR013281 | Apoptosis regulator, Mcl-1 | Family | |
IPR020728 | Apoptosis regulator, Bcl-2, BH3 motif, conserved site | Conserved Site |